JAMA Dermatology

08/09/2026

A woman in her 30s presented with a 22-year history of progressively enlarging, painless subcutaneous nodules that first appeared on her Achilles tendons during adolescence and eventually involved the elbows, wrists, knees, and iliac crests. What is your diagnosis?

A woman in her 30s presented with a 22-year history of progressively enlarging, painless subcutaneous nodules that first appeared on her Achilles tendons during adolescence and eventually involved the elbows, wrists, knees, and iliac crests. What is your diagnosis?

08/09/2026

For approved , adalimumab showed the most favorable cost-efficiency profile across the US, Canada, France, Germany, and Australia in this economic evaluation.

https://ja.ma/4hgyzjQ

08/08/2026

Pyoderma gangrenosum (PG) is a rare neutrophilic characterized by sterile ulcerative skin lesions.

Multiple comorbidities and clinical features have been associated with PG, but no standardized guidelines exist for classifying PG phenotypes.

📣 This consensus statement reflects an expert-established classification framework for pyoderma gangrenosum phenotypes.

https://ja.ma/4xsHnaX

08/08/2026

Among approved monoclonal antibody therapies for , adalimumab consistently appeared on the efficiency frontier across the US, Canada, France, Germany, and Australia, indicating the most favorable balance of cost and clinical response in this analysis.

The findings also showed substantial cross-country variation in biologic pricing, which may inform payer and reimbursement decisions for used in moderate to severe disease.

https://ja.ma/4hWiS1m

08/06/2026

📄 This case report describes 2 patients taking osimertinib and amivantamab who developed ecthymalike ulcerations refractory to tetracyclines and topical steroids.

08/03/2026

A cross-sectional study of asymptomatic patients seeking periodic skin examinations for concerns found that a substantial proportion were at low risk for skin cancer diagnosis. Most skin cancers detected occurred in patients older than 50 years and those with skin phototypes I through III.

The number needed to examine to diagnose 1 skin cancer was markedly lower among older patients, those reporting personal history of skin cancer, and those with lighter skin phototypes, highlighting the potential value of triage based on age, skin type, and prior skin cancer history.

https://ja.ma/4yTiy9H

08/01/2026

From 1990 to 2023, the global burden of malignant melanoma, cutaneous squamous cell carcinoma, and basal cell carcinoma increased, with the greatest disability-adjusted life-years (DALYs) concentrated in high Sociodemographic Index (SDI) regions such as Oceania, North America, and Northern Europe.

However, rapid increases in incidence and burden were observed in low- and middle-SDI regions, particularly for melanoma. While melanoma DALYs declined in high-SDI areas, squamous cell carcinoma and basal cell carcinoma showed persistent or rising trends.

Projections using a Bayesian age-period-cohort model indicate that by 2050, melanoma DALYs will rise to more than 3.3 million, squamous cell carcinoma to 4.0 million, and basal cell carcinoma to nearly 5.0 million globally, with the steepest relative increases in low- and middle-SDI countries.

These findings highlight shifting patterns in the epidemiology of skin cancer and the need for expanded prevention and surveillance efforts beyond high-income settings.

https://ja.ma/4pSKGpu

07/31/2026

A previously healthy woman in her 30s presented with a diffuse maculopapular rash, most prominently on her legs, with pitted necrotic spots, black eschar, and serous fluid weeping with diffuse edema. What is your diagnosis?

07/30/2026

📄 This case report describes a patient with adenopathy and extensive skin patch overlying a plasmacytoma (AESOP) syndrome with solitary plasmacytoma. https://ja.ma/4bjg1M4

07/30/2026

📄 This case report describes a man in his 40s with a large nodular plaque on the upper back without associated pain, bleeding, or systemic symptoms. https://ja.ma/4vY0HvP