06/11/2026
When it comes to selecting a biologic for severe asthma, biomarkers are only part of the equation. Payel Gupta, MD, allergist and immunologist at Ease Allergy Clinic and Mount Sinai, breaks down how IgE, FeNO, and blood eosinophil counts inform first-line biologic choice, as well as where the the field still falls short of true precision medicine.
Key clinical takeaways from her conversation with HCPLive:
• About 10% of patients don't respond to the first biologic selected
• If a patient isn't improving within 1–2 months, Gupta typically looks to switch to an agent with a different mechanism of action
• Type 2 comorbidities (atopic dermatitis, EoE, CRSwNP, CSU) can tip the scale toward a biologic approved across multiple indications—a potential "2-for-1" benefit
Read the full Q&A here: https://hubs.li/Q04k_rdD0