06/15/2026
Low back pain is defined as pain located below the costal margin and above the inferior gluteal folds, with or without leg pain and is the leading cause of years lived with worldwide, affecting people of all ages.
Approximately 1 in 4 US workers report low back pain, with mean lifetime prevalence of approximately 40% in adults. Approximately 90% of cases presenting in clinical settings are classified as nonspecific low back pain, with no identified pathoanatomical cause. Initial management emphasizes advice, education, and continued activity.
For acute nonspecific low back pain, first-line therapies include nonpharmacological treatments such as heat application, spinal manipulation, massage, and acupuncture, along with nonsteroidal anti-inflammatory drugs (NSAIDs) and skeletal muscle relaxants.
Chronic nonspecific low back pain is less likely to resolve but is managed with exercise, psychological therapies (such as cognitive behavioral therapy), and multidisciplinary approaches, with NSAIDs considered as second-line therapy.
📝This JAMA Review summarizes the epidemiology, pathophysiology, clinical evaluation, prognosis, and treatment of nonspecific low back pain in the outpatient setting.
https://ja.ma/43AFjkE