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09/24/2025

09/22/2025

Mark Mongiardo spent years confused and stigmatized by symptoms that mimicked alcoholism—slurred speech, balance issues, and the unmistakable smell of alcohol—despite not drinking. A dedicated teacher and coach, he was repeatedly called into school offices, arrested twice for DWIs, and even faced doubt from his wife, who believed he might be secretly drinking. After searching online, he discovered auto-brewery syndrome, a rare condition where gut microbes convert carbs into alcohol, leading to real intoxication without a single drink. A glucose challenge test confirmed it: his blood alcohol level spiked to 0.14 within an hour of consuming sugar.

By the time he got diagnosed in 2019, Mongiardo had already sold his house and moved in with family—part of the fallout from legal and career consequences. With felony charges pending, he couldn’t pass background checks for teaching jobs and struggled to find work, eventually taking a job at Target and later moving to Florida to rebuild as a real estate agent. Now living with a strict no-carb diet and regularly checking his BAC, he hopes his story brings awareness to a condition that nearly derailed his life.

09/21/2025

Scientists have achieved a groundbreaking milestone in the fight against HIV by developing a CRISPR-based therapy that removes HIV DNA from infected human cells and prevents the virus from returning. This revolutionary approach targets the viral genetic material directly, effectively erasing HIV from the cell’s genome and halting its ability to replicate.

In laboratory studies, treated cells showed no signs of viral rebound, offering a potential pathway toward a permanent cure for HIV, a disease that has affected millions globally. Unlike traditional antiretroviral therapies, which only suppress the virus, this CRISPR therapy tackles the root cause, providing hope for a one-time treatment with long-lasting effects.

Researchers emphasise that while early results are promising, further studies and clinical trials are required to ensure safety and efficacy in humans. If successful, this therapy could transform HIV treatment and bring the world closer to ending the HIV/AIDS epidemic once and for all.

09/17/2025

A fight on board a Royal Caribbean cruise ship forced the ship to return to port. https://bit.ly/47LAw32

09/16/2025

Spending nearly half a year in orbit changes a person forever. One astronaut, after 178 days in space, has returned with a shocking perspective—he believes we’re living a “lie.” His words aren’t about conspiracy, but about the way we see our place in the universe.

From space, Earth looks fragile, breathtaking, and shockingly small against the infinite blackness. Borders vanish, conflicts seem petty, and the planet itself appears as one interconnected organism. For astronauts, this view often triggers what’s called the Overview Effect—a profound shift in awareness that makes them question everything we take for granted back on the ground.

The “lie,” he suggests, is the illusion of separation. We’re taught to see ourselves divided by nations, politics, and identities, but from orbit, there is no separation—only one planet, one atmosphere, one human family. The thin blue line of Earth’s atmosphere is all that shields us from the cold void of space, and it suddenly becomes clear how fragile and precious life here truly is.

His words echo a warning and a call to action. If humanity continues to live under the “lie” of division, we risk destroying the very home that sustains us. But if we can embrace the truth seen from space—that we are united passengers on a shared world—we may still protect it for future generations.

Space travel doesn’t just expand our reach into the cosmos—it expands our minds. And sometimes, it takes 178 days in orbit to realize the most important discovery of all: that the biggest lie is forgetting we are all in this together.

09/13/2025

A UCL-led Randomized Crossover Trial found that people on a Minimally Processed Food (MPF) diet lost nearly twice as much weight as those on an Ultra-Processed Food (UPF) diet, even though both were nutritionally matched.

Among 55 adults alternating eight weeks on each diet, MPF meals (e.g., overnight oats, homemade spaghetti Bolognese) led to 2.06% weight loss, compared to 1.05% on UPF meals (e.g., ready-made lasagna, packaged oat bars).

The MPF group had a larger daily calorie deficit (290 vs. 120 kcal), greater fat loss with muscle preservation, and better food craving control—with twice the overall improvement and four times the improvement for savory cravings.

No significant short-term differences appeared in cholesterol or blood pressure, but researchers suggest longer studies may reveal health benefits, highlighting the role of food processing in weight management and calling for better access to whole, minimally processed foods.

Source: Dicken, S. J., Jassil, F. C., Brown, A., Kalis, M., Stanley, C., Ranson, C., Ruwona, T., Qamar, S., Buck, C., Mallik, R., Hamid, N., Bird, J. M., Brown, A., Norton, B., Gandini Wheeler-Kingshott, C. A. M., Hamer, M., van Tulleken, C., Hall, K. D., Fisher, A., Makaronidis, J., & Batterham, R. L. (2025). Ultraprocessed or minimally processed diets following healthy dietary guidelines on weight and cardiometabolic health: a randomized, crossover trial. Nature Medicine, (2025), August 4.

09/12/2025

Jeanne Calment, born February 21, 1875, in Arles, France, lived a remarkable 122 years, the longest confirmed human lifespan. Growing up in a wealthy family, she enjoyed painting and music. She married Fernand Calment in 1896, and they had one daughter, Yvonne. Calment witnessed two world wars and significant societal changes, maintaining an active lifestyle, including cycling and swimming, well into her later years.

At 85, Calment made a deal to sell her apartment to lawyer André-François Raffray, who agreed to pay her monthly until her death, expecting a short wait. She outlived him, receiving payments for 30 years. She smoked until 117, ate chocolate, and credited olive oil, port wine, and laughter for her longevity. Calment died on August 4, 1997, leaving a legacy as the oldest documented person.

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09/11/2025

As a result of the recent developments in the AP voting standards, we at Boldcastify College Sports are approaching this matter with utmost seriousness. Having thoroughly analyzed the information and statistics prior to making votes, the rankings will now be unveiled every Tuesday at 2 PM, starting next week.

09/06/2025

REST IN PEACE | Patrick Hemingway, the last surviving child of Ernest Hemingway, died Tuesday at age 97. FULL STORY (⬇️)

09/04/2025

09/03/2025