APL Bioengineering

APL Bioengineering APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering.

The newest member of the Applied Physics Letters family and the sister journal to APL Materials and APL Photonics. APL Bioengineering is devoted to research at the intersection of Biology, Physics, and Engineering. From drug delivery and tissue engineering to biosensors and biomedical devices, APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioeng

ineering open access ensures your research is available any time, any place and being open access, meets funder mandates everywhere.

The study shows that upon exposing endothelial cells to increased pressure, the protein (VE-cadherin) that ‘glues’ the c...
09/05/2025

The study shows that upon exposing endothelial cells to increased pressure, the protein (VE-cadherin) that ‘glues’ the cells together become destabilised, and this could cause ‘leaky blood vessels’.

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Despite the effects of shear stress on endothelial biology having been extensively researched, the effects of hydrostatic vascular pressure at extremely low she

The authors present a customizable microfluidic device enabling flexible spheroid culture, configurable flow connections...
09/04/2025

The authors present a customizable microfluidic device enabling flexible spheroid culture, configurable flow connections, and noninvasive 3D viability analysis using optical coherence tomography (OCT).

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3D cell spheroids have become crucial in vitro models for biomedical research, yet maintaining their growth and viability remains challenging due to diffusion l

The authors propose a novel graph neural network for cancer feature extraction, using sample relations. It updates featu...
09/03/2025

The authors propose a novel graph neural network for cancer feature extraction, using sample relations. It updates features with task-specific loss, outperforming recent radiomics methods.

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Radiomics methods are essential in cancer image analysis due to their excellent ability in extracting quantitative imaging features. Existing radiomics methods

Microfluidic platforms allow scientists to culture 3D cell aggregates — spheroids — to test the efficacy of new drugs an...
08/15/2025

Microfluidic platforms allow scientists to culture 3D cell aggregates — spheroids — to test the efficacy of new drugs and study disease mechanisms in vitro.

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Easily reconfigurable microfluidic platform can grow spheroids from various cell lines needed for pharmaceutical experiments.

Noninvasive continuous blood pressure monitoring using infrared spectroscopy and machine learning. Learn more 👇
07/31/2025

Noninvasive continuous blood pressure monitoring using infrared spectroscopy and machine learning.

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Diffuse correlation spectroscopy and a machine learning algorithm can provide continuous blood pressure feedback, enabling real-time monitoring during surgery a

Medical imaging can be used to diagnose diseases, monitor their progression, and evaluate their treatment, often providi...
07/24/2025

Medical imaging can be used to diagnose diseases, monitor their progression, and evaluate their treatment, often providing immediate and accurate feedback that can lead to faster responses and better patient outcomes.

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By learning the relevant features of clinical images along with the relationships between them, the neural network can outperform more traditional methods.

This review highlights the use of polymer-based drug delivery systems to overcome ocular barriers in retinal diseases, f...
07/11/2025

This review highlights the use of polymer-based drug delivery systems to overcome ocular barriers in retinal diseases, facilitating sustained, targeted, and minimally invasive therapies.

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Retinal diseases, such as age-related macular degeneration and diabetic macular edema, are significant contributors to vision loss. While injection of anti-vasc

Lee et al used a brain-on-a-chip model to show that in Alzheimer’s, toxic tau protein makes brain support cells (astrocy...
07/11/2025

Lee et al used a brain-on-a-chip model to show that in Alzheimer’s, toxic tau protein makes brain support cells (astrocytes) overly contract, squeezing vessels and blocking brain waste clearance.

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The glymphatic system is a critical pathway for clearing metabolic waste from the brain by mediating cerebrospinal fluid and interstitial fluid exchange. In Alz

The study uses an organ-chip to reveal how shear stress regulates inflammation in arterial endothelial cells and involve...
07/10/2025

The study uses an organ-chip to reveal how shear stress regulates inflammation in arterial endothelial cells and involvement of primary cilia and YAP as therapeutic targets for atherosclerosis.

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This study describes the development of a microfluidic chip model of the coronary artery endothelium and its use to examine the mechanism through which pulsatil

Traditional drug delivery vehicles fail to efficiently deliver and release cancer therapeutics of large molecular weight...
07/10/2025

Traditional drug delivery vehicles fail to efficiently deliver and release cancer therapeutics of large molecular weight to tumor cells.

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A drug delivery platform based on peptide coacervate microdroplets offers an avenue for synergistic cancer therapy.

Drug delivery to the posterior segment of the eye is significantly more difficult than to the anterior segment. Learn m...
07/08/2025

Drug delivery to the posterior segment of the eye is significantly more difficult than to the anterior segment.

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Advancements in polymer science are transforming the retinal disease treatment landscape, addressing clinical challenges such as treatment invasiveness, patient

As the average age of the global population increases, healthcare systems must adapt to treating chronic wounds in elder...
06/24/2025

As the average age of the global population increases, healthcare systems must adapt to treating chronic wounds in elderly patients.

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Review considers how biomaterials could aid in the study and treatment of wounds in aged skin.

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