APL Bioengineering

11/18/2020

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The latest on biomedical materials and devices from APL Bioengineering!

11/17/2020

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The latest on biomedical materials and devices from APL Bioengineering!

11/13/2020

Great virtual meeting with the APL Bioengineering Editorial Advisory Board! Thanks to our global team of leaders in the field of bioengineering!

11/11/2020

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Catch up on the most highly cited articles published in APL Bioengineering!

11/10/2020

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Catch up on the most highly cited articles published in APL Bioengineering!

11/04/2020

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One of the most cited articles published in APL Bioengineering.

10/30/2020

We’ve missed speaking with the bioengineering community in person at conferences this year, so we’re bringing the exhibit to you.

Check out our video of APL Bioengineering Editor-in-Chief Justin Cooper-White and see what’s new with the journal: http://ow.ly/DX1450C7350

10/29/2020

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Read one of the most cited articles published in APL Bioengineering.

10/23/2020

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APL Bioengineering is celebrating Open Access Week with top cited articles from the journal!

10/20/2020

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Artificial intelligence is lauded for its ability to solve problems humans cannot, thanks to novel computing architectures that process large amounts of complex data quickly. As a result, AI methods, such as machine learning, computer vision, and neural networks, are applied to some of the most difficult problems in science and society.

10/19/2020

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Catch up with the latest on Biomechanics research from APL Bioengineering!

10/14/2020

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A review summarizes commonly used light-based bioprinting techniques and their underlying interactions between light and cells or polymers.

10/14/2020

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Highlighted research in stem cell engineering, gene therapy, and drug delivery from APL Bioengineering.

10/12/2020

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Highlighted research on stem cell engineering, gene therapy, and drug delivery from APL Bioengineering.

10/05/2020

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By combining Organ-on-a-chip technology with centrifugal microfluidics, researchers move microphysiological systems onto Organ-Discs, a technology with a higher throughput.

10/02/2020

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Highlighted research on stem cell engineering, gene therapy, and drug delivery in APL Bioengineering.

09/29/2020

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Read the latest on “Stem Cell Engineering, Gene Therapy, and Drug Delivery” from APL Bioengineering.

09/21/2020

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Hepatocellular carcinoma is a particularly stubborn form of cancer with few treatments and a high mortality rate. It is usually treated by blocking the flow of blood to the tumor to induce cancer cell death. The common treatment, transarterial chemoembolization, is invasive and too imprecise to be a local drug delivery method.

09/16/2020

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Highlighted research on stem cell engineering, gene therapy, and drug delivery from APL Bioengineering.

09/10/2020

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Highlighted research in stem cell engineering, gene therapy, and drug delivery from APL Bioengineering.

09/07/2020

Fine-tuning of noise in gene expression with nucleosome remodeling

Gene expression may be modulated by its variability or mean behaviors. Here, Megaridis et al. (@BIOENGatIL) examine the effects on HIV expression noise by knocking down the BAF nucleosome remodeling complex in a dose-dependent manner.

http://ow.ly/gQqD50B1R72

Engineering stochastic fluctuations of gene expression (or “noise”) is integral to precisely bias cellular-fate decisions and statistical phenotypes in both single-cell and multi-cellular systems. ...

09/06/2020

Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids

The authors review recent biomaterial-based strategies to optimize brain organoid culture and manipulate its 3D microenvironment, which has the potential to increase its translational value in high-throughput applications.

http://ow.ly/F4gx50B1R1v

Stem cell-derived brain organoids provide a powerful platform for systematic studies of tissue functional architecture and the development of personalized therapies. Here, we review key advances at...

09/05/2020

Critical roles of time-scales in soft tissue growth and remodeling

A full-spectrum examination of the timescales present in biological growth and remodeling processes reveals the need to explore a new class of models to allow for more precise and efficient analysis.

http://ow.ly/JMud50B1QY5

Most soft biological tissues exhibit a remarkable ability to adapt to sustained changes in mechanical loads. These macroscale adaptations, resulting from mechanobiological cellular responses, are i...

09/04/2020

A microscale biomimetic platform for generation and electro-mechanical stimulation of 3D cardiac microtissues

A novel electro-mechanical Organ-on-Chip provides a combined electric field and cyclic uniaxial strain stimulation to 3D cardiac in vitro models for drug screening and basic research purposes.

http://ow.ly/pLtO50B1QS3

Organs-on-chip technology has recently emerged as a promising tool to generate advanced cardiac tissue in vitro models, by recapitulating key physiological cues of the native myocardium. Biochemica...

09/03/2020

Non-steric-zipper models for pathogenic α-synuclein conformers

Complexity in conformation: Experimental and simulation evidence for the existence of a β-helical form of α-synuclein that could represent a new therapeutic target

http://ow.ly/Lgmb50B1QOS

Parkinson's disease neurodegenerative brain tissue exhibits two biophysically distinct α-synuclein fiber isoforms—single stranded fibers that appear to be steric-zippers and double-stranded fibers ...

09/02/2020

Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration

A microcontact printing approach to explore the wide parameter space of ECM properties (fiber alignment, density, diameter) reveals that alignment of adhesive ligand defines fibroblast migration mode by organizing focal adhesions.

http://ow.ly/TYPt50B1QIp

Physical features of the extracellular matrix (ECM) heavily influence cell migration strategies and efficiency. Migration in and on fibrous ECMs is of significant physiologic importance, but limita...

09/01/2020

Plasma ion implantation enabled bio-functionalization of PEEK improves osteoblastic activity

Looking for PEEK orthopaedic implants with bone-like mechanics and superior bioactivity? Find out how the authors used surface plasma modification and tropoelastin to augment polymer-tissue integration.

http://ow.ly/3VFG50B1QFb

Slow appositional growth of bone in vivo is a major problem associated with polyether ether ketone (PEEK) based orthopaedic implants. Early stage promotion of osteoblast activity, particularly bone...

08/31/2020

MRI analysis to map interstitial flow in the brain tumor microenvironment

Interstitial fluid flow increases invasion of tumor cells, but what does it look like? Using MRI and biotransport modeling, the authors map flow velocities in and around brain tumors for the first time.

http://ow.ly/pWUn50B1QBe

Glioblastoma (GBM), a highly aggressive form of brain tumor, is a disease marked by extensive invasion into the surrounding brain. Interstitial fluid flow (IFF), or the movement of fluid within the...

08/31/2020

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Highlighted research in stem cell engineering, gene therapy, and drug delivery published in APL Bioengineering.

08/30/2020

A tunable microfluidic 3D stenosis model to study leukocyte-endothelial interactions in atherosclerosis

Stenosis-on-a-chip: Role of pneumatic-controlled vessel constrictions in leukocyte-endothelial interactions during blood perfusion. Leukocyte adhesion shown be a potential biomarker in atherosclerosis

http://ow.ly/bQ3R50B1Qvy

Atherosclerosis, a chronic inflammatory disorder characterized by endothelial dysfunction and blood vessel narrowing, is the leading cause of cardiovascular diseases including heart attack and stro...

08/29/2020

Photolithographic shape control of DNA hydrogels by photo-activated self-assembly of DNA nanostructures

A photolithographic fabrication method for DNA hydrogels with arbitrary-shaped patterns has been developed, which can be applied to a wide variety of biomedical engineering and molecular robotics.

http://ow.ly/vigr50B1QkY

We report a photolithographic method for the shape control of DNA hydrogels based on photo-activated self-assembly of Y-shaped DNA nanostructures (Y-motifs). To date, various methods to control the...

08/28/2020

Computational study of aortic hemodynamics for patients with an abnormal aortic valve: The importance of secondary flow at the ascending aorta inlet

This computational study discusses the importance of using 3D velocity profiles as inlet boundary condition for an accurate evaluation of the aortic hemodynamics in patients with aortic valve disease.

http://ow.ly/REb250B1QfR

Blood flow in the aorta is helical, but most computational studies ignore the presence of secondary flow components at the ascending aorta (AAo) inlet. The aim of this study is to ascertain the imp...

08/28/2020

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Highlighted research in stem cell engineering, gene therapy, and drug delivery published in APL Bioengineering.

08/27/2020

Review: Biomaterial systems to resolve brain inflammation after traumatic injury

Until recently the brain was considered to be immunologically privileged: it is not! Neuroinflammation actually impedes adult neurogenesis. Here, the authors review how biomaterials can be used to attenuate inflammation and enhance neurogenesis.

http://ow.ly/gPoI50B1Q6F

The inflammatory response within the central nervous system (CNS) is a tightly regulated cascade of events which is a balance of both cytotoxic and cytotrophic effects which determine the outcome o...

08/26/2020

Biohybrid robot with skeletal muscle tissue covered with a collagen structure for moving in air

The authors proposed a muscle-powered biohybrid robot driven in air. The skeletal muscle tissue in the robot was encapsulated in a collagen structure to maintain the required humidity conditions when operated in air.

http://ow.ly/lqun50B1Q2d

Biohybrid robots composed of biological and synthetic components have been introduced to reconstruct biological functions in mechanical systems and obtain better understanding of biological designs...