APL Bioengineering

APL Bioengineering APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems.

The newest member of the Applied Physics Letters family and the sister journal to APL Materials and APL Photonics. APL Bioengineering is devoted to research at the intersection of Biology, Physics, and Engineering. From drug delivery and tissue engineering to biosensors and biomedical devices, APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioeng

The newest member of the Applied Physics Letters family and the sister journal to APL Materials and APL Photonics. APL Bioengineering is devoted to research at the intersection of Biology, Physics, and Engineering. From drug delivery and tissue engineering to biosensors and biomedical devices, APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioeng

High-throughput combinatorial synthesis and screening is a powerful strategy to screen drug delivery systems with enhanc...
10/08/2021
High-throughput screening of nanoparticles in drug delivery

High-throughput combinatorial synthesis and screening is a powerful strategy to screen drug delivery systems with enhanced targeting and release, accelerating in vivo testing and clinical translation

The use of pharmacologically active compounds to manage and treat diseases is of utmost relevance in clinical practice. It is well recognized that spatial-temporal control over the delivery of thes...

Better models could improve liver cancer treatment
10/07/2021
Better models could improve liver cancer treatment

Better models could improve liver cancer treatment

Understanding the microenvironment of tumors and using in vitro models that properly reflect it will improve the development of immunotherapies for liver cancer.

Simple nanoscale surface engineering of metallic coronary stents can offer an efficacious and cost-effective alternative...
06/08/2021
Surface engineering at the nanoscale: A way forward to improve coronary stent efficacy

Simple nanoscale surface engineering of metallic coronary stents can offer an efficacious and cost-effective alternative to drug eluting stents to prevent neointimal hyperplasia and restenosis.

Coronary in-stent restenosis and late stent thrombosis are the two major inadequacies of vascular stents that limit its long-term efficacy. Although restenosis has been successfully inhibited throu...

This review outlines the design requirements of Tissue Engineered Vascular System, and explores the advances in biofabri...
05/25/2021
Biofabrication of tissue engineering vascular systems

This review outlines the design requirements of Tissue Engineered Vascular System, and explores the advances in biofabrication methods and biomaterials with special focus on in-vitro applications of TEVS for disease modeling.

Cardiovascular disease (CVD) is the leading cause of death among persons aged 65 and older in the United States and many other developed countries. Tissue engineered vascular systems (TEVS) can ser...

This review summarizes recently used cell surface engineering techniques with functional bionanomaterials for cancer imm...
05/24/2021
Functional bionanomaterials for cell surface engineering in cancer immunotherapy

This review summarizes recently used cell surface engineering techniques with functional bionanomaterials for cancer immunotherapy and comments future perspectives on the development of cell surface engineering.

The cell surface is the forward position in cancer immunotherapy, with surface ligand and receptor interactions between various cells for determining immune privilege or recognition. Therefore, cel...

Engineered systems have taken a step forward to design #mechanotransduction platforms imparting diverse mechanical stres...
05/14/2021
Mechanotransduction assays for neural regeneration strategies: A focus on glial cells

Engineered systems have taken a step forward to design #mechanotransduction platforms imparting diverse mechanical stresses to #glialcells with #biomechanical relevance of the #CentralNervousSystem tissues. #CNS #glia #nerveregeneration

Nanyang Technological University, Singapore

Glial cells are mechanosensitive, and thus, engineered systems have taken a step forward to design mechanotransduction platforms in order to impart diverse mechanical stresses to cells. Mechanical ...

Microfluidics is a burgeoning field with numerous biomedical applications. In this review, the authors summarize progres...
04/28/2021
Label-free microfluidic sorting of microparticles

Microfluidics is a burgeoning field with numerous biomedical applications. In this review, the authors summarize progress and challenges in label-free microfluidic sorting of cells and microparticles.

#Microfluidics #InertialMicrofluidics #CellSorting

Massive growth of the microfluidics field has triggered numerous advances in focusing, separating, ordering, concentrating, and mixing of microparticles. Microfluidic systems capable of performing ...

This article provides an overview of engineering neural tissues by 3D bioprinting. The authors promulgate “next generati...
04/13/2021
Engineering in vitro human neural tissue analogs by 3D bioprinting and electrostimulation

This article provides an overview of engineering neural tissues by 3D bioprinting. The authors promulgate “next generation” tissue building with electrical stimulation to enhance printed tissue formation and maturation.

There is a fundamental need for clinically relevant, reproducible, and standardized in vitro human neural tissue models, not least of all to study heterogenic and complex human-specific neurologica...

This review discusses heterogeneity in the adipose organ, how heterogeneity translates into depot-specific stem cell fea...
04/09/2021
Harnessing adipose stem cell diversity in regenerative medicine

This review discusses heterogeneity in the adipose organ, how heterogeneity translates into depot-specific stem cell features and how atypical populations may be harnessed for regenerative medicine.

Since the first isolation of mesenchymal stem cells from lipoaspirate in the early 2000s, adipose tissue has been a darling of regenerative medicine. It is abundant, easy to access, and contains hi...

This review article takes a critical look at the prospects and challenges in using extracellular vesicles for cancer det...
03/29/2021
Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy

This review article takes a critical look at the prospects and challenges in using extracellular vesicles for cancer detection and therapy, through the lenses of both basic science and engineering.

Exosomes are small (∼30–140 nm) lipid bilayer-enclosed particles of endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most cell types. There has been growing ...

Incorporating regular macropores into injectable hydrogels improves tissue repair and efficacy of locally delivered gene...
03/11/2021
Injectable, macroporous scaffolds for delivery of therapeutic genes to the injured spinal cord

Incorporating regular macropores into injectable hydrogels improves tissue repair and efficacy of locally delivered gene therapies after spinal cord injury in mice.

UCLA

Biomaterials are being developed as therapeutics for spinal cord injury (SCI) that can stabilize and bridge acute lesions and mediate the delivery of transgenes, providing a localized and sustained...

This review article covers the current state of art bioengineered models to mimic the microenvironment of the neurovascu...
03/08/2021
Bioengineering the neurovascular niche to study the interaction of neural stem cells and endothelial cells

This review article covers the current state of art bioengineered models to mimic the microenvironment of the neurovascular niche and use it to better understand the interactions of neural stem cells and endothelial cells.

Northeastern University

The ability of mammalian neural stem cells (NSCs) to self-renew and differentiate throughout adulthood has made them ideal to study neurogenesis and attractive candidates for neurodegenerative dise...

This new article highlights recent development of stimuli-responsive biomaterials to reproduce the complex and dynamic m...
03/04/2021
Stimuli-responsive biomaterials for cardiac tissue engineering and dynamic mechanobiology

This new article highlights recent development of stimuli-responsive biomaterials to reproduce the complex and dynamic microenvironment of the native heart for cardiac tissue engineering and dynamic mechanobiology studies.

Syracuse University

Since the term “smart materials” was put forward in the 1980s, stimuli-responsive biomaterials have been used as powerful tools in tissue engineering, mechanobiology, and clinical applications. For...

The review summarizes the deficiencies and advantages of various existing wound dressings, and outlines the recent advan...
02/18/2021
Recent advances on polymeric hydrogels as wound dressings

The review summarizes the deficiencies and advantages of various existing wound dressings, and outlines the recent advances, challenges and future perspectives of high-performance hydrogel wound dressings.

Severe hemorrhage is a leading cause of high mortality in critical situations like disaster, accidents, and warfare. The resulting wounds could induce severe physical and psychological trauma to pa...

Characterization of an in-gel polymerase elongation process revealed that DNA polymerase diffusion was impeded by molecu...
01/28/2021
In-gel fluorescence detection by DNA polymerase elongation

Characterization of an in-gel polymerase elongation process revealed that DNA polymerase diffusion was impeded by molecular interactions with immobilized DNA. This finding will inform design of gel-based assays.

UC Berkeley

Fluorescence-based DNA readouts are increasingly important in biological research, owing to enhanced analytical sensitivity and multiplexing capability. In this study, we characterize an in-gel pol...

Check our latest in APL Bioengineering by @MJMitchell_Lab @pennbioeng on peptide functionalized liposomes for receptor t...
01/26/2021
Peptide functionalized liposomes for receptor targeted cancer therapy

Check our latest in APL Bioengineering by @MJMitchell_Lab @pennbioeng on peptide functionalized liposomes for receptor targeted cancer therapy!

University of Pennsylvania

Most clinically approved cancer therapies are potent and toxic small molecules that are limited by severe off-target toxicities and poor tumor-specific localization. Over the past few decades, atte...

In response to injury, endothelial cells and fibroblasts within an engineered 3D vascularized tissue dynamically contrac...
01/25/2021
Reconstituting the dynamics of endothelial cells and fibroblasts in wound closure

In response to injury, endothelial cells and fibroblasts within an engineered 3D vascularized tissue dynamically contract the wound, migrate, and distribute matrix to close the void.

Boston University College of Engineering
Boston University

The formation of healthy vascularized granulation tissue is essential for rapid wound closure and the prevention of chronic wounds in humans, yet how endothelial cells and fibroblasts coordinate du...

This perspective by Alana Welm and colleagues outlines the challenges of modeling the complexities of cancer and new pro...
01/22/2021
Toward improved models of human cancer

This perspective by Alana Welm and colleagues outlines the challenges of modeling the complexities of cancer and new progress toward improved in vivo models to advance therapeutic development.

The University of Utah

Human cancer is a complex and heterogeneous collection of diseases that kills more than 18 million people every year worldwide. Despite advances in detection, diagnosis, and treatments for cancers,...

Microrheology is a versatile tool for material characterization. Its use as a tool in designing biomaterials as physiolo...
01/19/2021
Microrheology for biomaterial design

Microrheology is a versatile tool for material characterization. Its use as a tool in designing biomaterials as physiological models, tissue engineering scaffolds, and therapeutic delivery vehicles are described in this new review in APL Bioengineering.

University of Maryland

Microrheology analyzes the microscopic behavior of complex materials by measuring the diffusion and transport of embedded particle probes. This experimental method can provide valuable insight into...

How can we use DNA nanostructures to probe cellular membranes? Here researchers review DNA nanotechnology, membrane biop...
01/15/2021
Emerging applications at the interface of DNA nanotechnology and cellular membranes: Perspectives from biology, engineering, and physics

How can we use DNA nanostructures to probe cellular membranes? Here researchers review DNA nanotechnology, membrane biophysics, delivery strategies and recent advances in applications for DNA nanotechnology at the membrane interface.

Carnegie Mellon University Carnegie Mellon Mechanical Engineering Department
CMU Physics Department

DNA nanotechnology has proven exceptionally apt at probing and manipulating biological environments as it can create nanostructures of almost arbitrary shape that permit countless types of modifica...

COVID-19 can be diagnosed by several tests like molecular-, immuno-, and nano-based assays. However, it is an urgent req...
01/14/2021
Evaluation of current diagnostic methods for COVID-19

COVID-19 can be diagnosed by several tests like molecular-, immuno-, and nano-based assays. However, it is an urgent requirement to discover more sensitive, specific, fast, and accurate tests.
Yıldız Teknik Üniversitesi

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent responsible for the coronavirus disease of 2019 (COVID-19), which triggers lung failure, pneumonia, and multi-organ dysfunc...

Metastatic cells navigate heterogeneous tumor microenvironments. Insights from computational models of migration modes w...
01/13/2021
Computational models of migration modes improve our understanding of metastasis

Metastatic cells navigate heterogeneous tumor microenvironments. Insights from computational models of migration modes with implications on metastasis are discussed and open questions are highlighted.

UC San Diego

Tumor cells migrate through changing microenvironments of diseased and healthy tissue, making their migration particularly challenging to describe. To better understand this process, computational ...

Understanding cell-light/polymer interactions is crucial in light-based bioprinting. Theoretical mechanisms, which condi...
01/11/2021
Fundamentals of light-cell–polymer interactions in photo-cross-linking based bioprinting

Understanding cell-light/polymer interactions is crucial in light-based bioprinting. Theoretical mechanisms, which condition cell response and the parameters essential for maintaining cell viability are summarized.

Biofabrication technologies that use light for polymerization of biomaterials have made significant progress in the quality, resolution, and generation of precise complex tissue structures. In rece...

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