APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering.
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The newest member of the Applied Physics Letters family and the sister journal to APL Materials and APL Photonics. APL Bioengineering is devoted to research at the intersection of Biology, Physics, and Engineering. From drug delivery and tissue engineering to biosensors and biomedical devices, APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioeng
ineering open access ensures your research is available any time, any place and being open access, meets funder mandates everywhere.
A review summarizing recent progress in organic nanoparticle-based imaging of different types of targeted cells and therapeutic methods for atherosclerosis.
Corticosteroids have for some time been used as first-line drugs for the topical treatment of noninfectious uveitis, but poor ocular bioavailability and the rap
Peng et al. propose a combination therapy for pancreatic cancer using targetting nanoparticles, showing improved drug loading release, higher release efficiency, and more accurate tumor-targeting efficacy!
Inkjet printing remains one of the most cost-efficient techniques for device prototyping and manufacturing, offering considerable freedom of digital design, non
APL Associate Editor Arianna Menciassi introduces Special Topic: Emerging Technologies in Wearable Sensors. Hear what she has to say and read the collection of articles on this important research 👇
APL Bioengineering Associate Editor Arianna Menciassi introduces a recently published Special Topic: Emerging Technologies in Wearable Sensors. Read the coll...
Rupture of an atherosclerotic plaque can lead to cardiovascular events. A tissue-engineered human plaque model suggests a detrimental role form microcalcifications in rupture mechanics.
Cases of respiratory tract diseases are on the rise, leading to increasing cases of airway stenosis, a narrowing of the airway that impairs breathing. Though some causes of stenosis are benign, most are associated with lung cancer.
Learn more 👇
All-in-one device can repair airflow, prevent infection, and threat the cancer that caused the obstruction.
Adverse effects of Sodium Selenite on the morphology and functionality of On-Chip Microvasculature.
Endothelial cells (ECs) possess a strong intrinsic clockwise (CW, or rightward) chirality under normal conditions. Enervating this chirality of ECs significantl
Check out recent research from Chen et al. showing us that their system offers sustained and focused EV release around the nerve-injury site to overcome rapid clearance and maintain EV bioactivity in vivo!
Fibrosis and fibroblast activation usually occur in the tissues surrounding a malignant tumor; therefore, anti-fibrotic drugs are used in addition to chemothera
An elegant study demonstrating the key role of endothelial cells in
The myocardium is a mechanically active tissue typified by anisotropy of the resident cells [cardiomyocytes (CMs) and cardiac fibroblasts (cFBs)] and the extrac
A safe drug formulation promises a new strategy for the treatment of non-infectious uveitis and ocular inflammatory diseases. Discover more with researchers from Tianjin Eye Hospital.
Innate immunity forms the core of the human body's defense system against infection, injury, and foreign objects. It aims to maintain homeostasis by promoting i
Great review by McGill MD-PhD Program and C. Moraes on engineering microenvironments for innate immune cell biophysics!
Fibrosis is one of the hallmarks of chronic liver disease and is associated with aberrant wound healing. Changes in the composition of the liver microenvironmen
Wearable devices for sweat analysis in sport activities? Possible using novel laser-induced graphene materials!
Medical microrobots (MRs) hold the potential to radically transform several interventional procedures. However, to guarantee therapy success when operating in h
This paper developed an one step method to form vascular network directly from human pluripotent stem cells.
During embryonic development, endothelial cells (ECs) undergo vasculogenesis to form a primitive plexus and assemble into networks comprised of mural cell-stabi
A thoughtful review on the and mechanobiology behind macrophage response to inflammation.
Circulating tumor cell (CTC) clusters that are shed from the primary tumor into the bloodstream are associated with a poor prognosis, elevated metastatic potent
Rashid Bashir and co-workers use optical stimulation and a scalable biofabrication process for developing biohybrid walkers with multi-directional walking capabilities
The scientific community has shown increasing interest in laser scribing for the direct fabrication of conductive graphene-based tracks on different substrates.
We aren’t kidney-ing around, this proximal-tubule-on-a-chip system is easy to build! It was used to compare the transcriptome of proximal tubule cells cultured with or without flow to native tubules.
Drug-induced nephrotoxicity is a leading cause of drug attrition, partly due to the limited relevance of pre-clinical models of the proximal tubule. Culturing p
Where do go? We need new methods for imaging and tracking them.
In many leukemia patients, a poor prognosis is attributed either to the development of chemotherapy resistance by leukemic stem cells (LSCs) or to the inefficie
Great work by the Papautsky lab on for of circulating tumor cells.
Biohybrid robots, composed of cellular actuators and synthetic scaffolds, have garnered much attention in recent years owing to the advantages provided by their
This paper shares a 3D in vitro model system for bone marrow .
Nanomaterial diffusion through mucus is important to basic and applied areas of research such as drug delivery. However, it is often challenging to interpret na
The proliferation of wearable technology leads to an increased demand for systems that can manage heat flow and ensure comfort for the wearer. Flexible thermoregulatory materials must be low-cost, easy to manufacture, and capable of adjusting to different conditions.
The dynamic infrared properties of composite materials are determined by their surface structure.
Current challenges and future perspectives of implementing fluid flow in microphysiological systems (organ-on-a-chip, organoids, etc.) for drug discovery and personalized medicine.
Many different strategies can be found in the literature to model organ physiology, tissue functionality, and disease in vitro; however, most of these models la
Peripheral nerves projecting to visceral organs are a major brain-body interface. Organ function is controlled by the signals sent by these nerves and received by the brain.
Spinal cord injuries were once viewed as nearly impossible to recover from. New medical technology and techniques, such as electrical stimulation, now hold the potential to restore spinal cord function by promoting tissue regrowth.
New simulation method enables prediction of promising treatments for spinal cord injury without requiring experimentation in patients.
Mechanical regulation of transport across the nucleus membrane occurs at two levels. This perspective shares insights into these mechanisms.
Osteoarthritis drugs are often short-acting; therefore, to enhance their efficacy, long-term, stable-release, drug-delivery systems are urgently needed. Mesopor
The biodegradability, biocompatibility, and self-assembly of DNA hydrogels make them promising materials for various medical applications. While many types of DNA hydrogels exist, researchers are not yet able to finely tune their properties.
Changing the structure of microscopic DNA ladders tailors hydrogels properties for potential applications in drug delivery, biosensing, and tissue engineering.
4D cardiac contraction of zebrafish is unveiled at the single-cell resolution by leveraging light-sheet imaging and VR interactive analysis.
Despite ongoing efforts in cardiovascular research, the acquisition of high-resolution and high-speed images for the purpose of assessing cardiac contraction re
Can nanofibers produced by electrospinning represent an asset for wearable devices? This review paper gives an answer, and the answer is “yes!”
Wearables have garnered significant attention in recent years not only as consumer electronics for entertainment, communications, and commerce but also for real
Machine learning with UMD Bioengineering - find out more about how we can predict nanoparticle mobility in body fluids!
Many inflammatory diseases that are responsible for a majority of deaths are still uncurable, in part as the underpinning pathomechanisms and how to combat them
Diseases like retinal pigmentosa and macular degeneration cause eye photoreceptors to degenerate, leading to vision loss. Because the optical neural network remains functional, artificial stimulation of the neurons can restore partial vision.
Organic bulk heterostructure junctions can be used as a retinal prosthetic in patients with retinal pigmentosa and age-related macular degeneration.
Let's talk about nuclear lamina mechanoprotection. The role of lamin expression in preserving our 2 meters of DNA.
The ability for wearable devices to collect high-fidelity biosignals continuously over weeks and months at a time has become an increasingly sought-after charac
Now Online: Drug/Gene delivery and theranostics
Drug/gene delivery utilizes novel pharmaceutical formulations to deliver therapeutic cargos specifically to the disease sites, lowering the likelihood of significant side effects....
Read More 👉 https://aippub.org/46bF921
Combining computational and experimental approaches to improve the patency of design
The blood-brain barrier (BBB) is a specialized brain endothelial barrier structure that regulates the highly selective transport of molecules under continuous b
Targeted drug delivery is poised to revolutionize medicine by increasing the therapeutic power of medications while minimizing their side effects. To make this future possible, the medication must release in the right location and in a controlled manner.
High-voltage pulsed electric fields cause a controlled release of medications from loaded red blood cells, offering a powerful anti-tumor application.
Are nuclear functions regulated by mechanical forces acting on the cell nucleus? Yes! Learn more in this Special Issue of APB!
Mesoporous polydopamine nanoparticles - a stable drug-release system that can inhibit cartilage damage and proteoglycan loss more effectively than the non-vectored drug treatment? Is knee osteoarthritis pain a thing of the past?
Embedding in which collect biosignals can enable the next generation autonomous diagnostic, therapeutic, and assistive health tools.
Nuclear lamins are type V intermediate filament proteins that polymerize into complex filamentous meshworks at the nuclear periphery and in less structured form
Reminder - This Special Topic is still open for submissions. Submit by December 31, 2023!
Learn more 👇
https://aippub.org/3Yt2FoB
Think Dorothy would like this Yellow Brick Road to understanding nuclear membrane
Nowadays, nonalcoholic fatty liver disease is a common metabolic liver disease of all ages worldwide. However, current pharmacological and surgical treatments a
Lower urinary tract dysfunctions can be caused by damage to the nervous system, such as spinal cord injuries or neurodegenerative disorders like Parkinson’s or Alzheimer’s.
The mechanism of selective transport through the nuclear pore complex is complicated and confusing, with various conflicting hypotheses. This mini-review will fill you in on all the details!
The nuclear pore complex (NPC) is a large protein assembly that perforates the nuclear envelope and provides a sole gateway for traffic between the cytoplasm an
APL is proud to sponsor the Young Investigator Awards 🏆 at Termis-AP 2023 Conference in Hong Kong, October 16th-18th! Congratulations to winners Dr. Zengping Liu, University of Singapore and Dr. Mark Colin Allenby, The University of Queensland
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Reminder - This Special Topic is still open for submissions. Submit by December 31, 2023! Learn more 👇 https://aippub.org/3Yt2FoB
