APL Bioengineering

APL Bioengineering APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering.

The newest member of the Applied Physics Letters family and the sister journal to APL Materials and APL Photonics. APL Bioengineering is devoted to research at the intersection of Biology, Physics, and Engineering. From drug delivery and tissue engineering to biosensors and biomedical devices, APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioeng

ineering open access ensures your research is available any time, any place and being open access, meets funder mandates everywhere.

Immune cells in the human heart release tiny particles that help blood vessels form in lab-grown heart tissues, revealin...
06/10/2026

Immune cells in the human heart release tiny particles that help blood vessels form in lab-grown heart tissues, revealing clues that could help guide future heart repair strategies.

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Resident cardiac macrophages, derived from primitive yolk sac precursors during embryogenesis, have increasingly been recognized for their distinct phenotype an

This article proposes a roadmap for the design of closed-loop patient specific bioelectronic implants to drastically imp...
04/13/2026

This article proposes a roadmap for the design of closed-loop patient specific bioelectronic implants to drastically improve treatment of glioblastoma, one of the hardest to treat cancers.

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Closed-loop bioelectronic devices offer a promising platform for responsive treatment to heterogeneous disease states. Glioblastoma, an aggressive form of brain

The authors develop a vertically integrated platform combining genetic engineering, photo-fabricated confinement, and lo...
04/12/2026

The authors develop a vertically integrated platform combining genetic engineering, photo-fabricated confinement, and long-term live fluorescence imaging to couple cell-cycle state with migration dynamics.

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Quantitative cell biology often examines migration and cell-cycle (CC) progression separately, limiting insights into their interplay under spatial constraints.

A novel nanodrug delivery system: to target inflamed arteries, reduce oxidative stress and shrink atherosclerotic plaque...
04/11/2026

A novel nanodrug delivery system: to target inflamed arteries, reduce oxidative stress and shrink atherosclerotic plaques in mice, showing promise for treating cardio-cerebrovascular diseases.

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Atherosclerosis and its complications are highly prevalent worldwide, and managing oxidative stress in endothelial cells to alleviate abnormal inflammatory dama

This study introduces StrokeRecovNet, an EEG-based machine learning model that predicts upper limb motor recovery after ...
03/06/2026

This study introduces StrokeRecovNet, an EEG-based machine learning model that predicts upper limb motor recovery after stroke, outperforming standard recovery rules in acute and subacute participants

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Electroencephalography (EEG) has shown promise in assessing and monitoring functional recovery in stroke survivors, but its utility in predicting upper limb mot

In this work, a synthetic mucus biomaterial-based formulation was developed for local antibody delivery designed to modu...
03/05/2026

In this work, a synthetic mucus biomaterial-based formulation was developed for local antibody delivery designed to modulate inflammatory immune responses directly at the mucosal surface.

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Inflammatory bowel disease (IBD) is a chronic condition characterized by recurrent gastrointestinal inflammation that requires long-term therapeutic interventio

Study shows EEG decoding of lower-limb movement intentions in SCI patients. Machine learning analysis achieved above-cha...
03/04/2026

Study shows EEG decoding of lower-limb movement intentions in SCI patients. Machine learning analysis achieved above-chance discrimination, establishing a baseline for neuroprosthetic applications.

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Restoring lower-limb function in patients with severe spinal cord injury (SCI) remains challenging. Spinal cord stimulation may enhance and reinstate lower-limb

How close are we really to bringing tissue regeneration to patients? This article highlights clinical successes, what’s ...
01/19/2026

How close are we really to bringing tissue regeneration to patients? This article highlights clinical successes, what’s slowing progress, and how biology, engineering, and AI are shaping patient care.

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https://aippub.org/45I9309

Regenerative medicine is transforming how we restore tissue function, leveraging advances in cell and molecular biology, biomaterials, and engineered microenvir

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