APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems.
The newest member of the Applied Physics Letters family and the sister journal to APL Materials and APL Photonics. APL Bioengineering is devoted to research at the intersection of Biology, Physics, and Engineering. From drug delivery and tissue engineering to biosensors and biomedical devices, APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioeng
The newest member of the Applied Physics Letters family and the sister journal to APL Materials and APL Photonics. APL Bioengineering is devoted to research at the intersection of Biology, Physics, and Engineering. From drug delivery and tissue engineering to biosensors and biomedical devices, APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioeng
Simple nanoscale surface engineering of metallic coronary stents can offer an efficacious and cost-effective alternative to drug eluting stents to prevent neointimal hyperplasia and restenosis.
Coronary in-stent restenosis and late stent thrombosis are the two major inadequacies of vascular stents that limit its long-term efficacy. Although restenosis has been successfully inhibited throu...
This review outlines the design requirements of Tissue Engineered Vascular System, and explores the advances in biofabrication methods and biomaterials with special focus on in-vitro applications of TEVS for disease modeling.
Cardiovascular disease (CVD) is the leading cause of death among persons aged 65 and older in the United States and many other developed countries. Tissue engineered vascular systems (TEVS) can ser...
This review summarizes recently used cell surface engineering techniques with functional bionanomaterials for cancer immunotherapy and comments future perspectives on the development of cell surface engineering.
The cell surface is the forward position in cancer immunotherapy, with surface ligand and receptor interactions between various cells for determining immune privilege or recognition. Therefore, cel...
Engineered systems have taken a step forward to design #mechanotransduction platforms imparting diverse mechanical stresses to #glialcells with #biomechanical relevance of the #CentralNervousSystem tissues. #CNS #glia #nerveregeneration
Nanyang Technological University, Singapore
Glial cells are mechanosensitive, and thus, engineered systems have taken a step forward to design mechanotransduction platforms in order to impart diverse mechanical stresses to cells. Mechanical ...
Using biofabricated tissue-engineered vascular systems to study cardiovascular disease
Tissue-engineered vascular systems that are biofabricated using novel materials can serve to model certain heart diseases, such as atherosclerosis, and to test drug therapies for these diseases.
Functional bionanomaterials help optimize surface engineering to improve cancer immunotherapy
A review summarizes using bionanomaterials for cell surface engineering – both ex vivo and in vivo – in cancer immunotherapy.
Microfluidics is a burgeoning field with numerous biomedical applications. In this review, the authors summarize progress and challenges in label-free microfluidic sorting of cells and microparticles.
#Microfluidics #InertialMicrofluidics #CellSorting
Massive growth of the microfluidics field has triggered numerous advances in focusing, separating, ordering, concentrating, and mixing of microparticles. Microfluidic systems capable of performing ...
This article provides an overview of engineering neural tissues by 3D bioprinting. The authors promulgate “next generation” tissue building with electrical stimulation to enhance printed tissue formation and maturation.
There is a fundamental need for clinically relevant, reproducible, and standardized in vitro human neural tissue models, not least of all to study heterogenic and complex human-specific neurologica...
This review discusses heterogeneity in the adipose organ, how heterogeneity translates into depot-specific stem cell features and how atypical populations may be harnessed for regenerative medicine.
Since the first isolation of mesenchymal stem cells from lipoaspirate in the early 2000s, adipose tissue has been a darling of regenerative medicine. It is abundant, easy to access, and contains hi...
This review article takes a critical look at the prospects and challenges in using extracellular vesicles for cancer detection and therapy, through the lenses of both basic science and engineering.
Exosomes are small (∼30–140 nm) lipid bilayer-enclosed particles of endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most cell types. There has been growing ...
Incorporating regular macropores into injectable hydrogels improves tissue repair and efficacy of locally delivered gene therapies after spinal cord injury in mice.
UCLA
Biomaterials are being developed as therapeutics for spinal cord injury (SCI) that can stabilize and bridge acute lesions and mediate the delivery of transgenes, providing a localized and sustained...
Injectable Porous Scaffolds Promote Better, Quicker Healing After Spinal Cord Injuries - AIP Publishing LLC
Link to article: Injectable, macroporous scaffolds for delivery of therapeutic genes to the injured spinal cord DOI: 10.1063/5.0035291 WASHINGTON, ...
This review article covers the current state of art bioengineered models to mimic the microenvironment of the neurovascular niche and use it to better understand the interactions of neural stem cells and endothelial cells.
Northeastern University
The ability of mammalian neural stem cells (NSCs) to self-renew and differentiate throughout adulthood has made them ideal to study neurogenesis and attractive candidates for neurodegenerative dise...
Neurovascular niche review introduces bioengineers to neural stem cells
Biologists’ understanding of the neurovascular niche, an important area in brain science, could benefit from bioengineering contributions.
This new article highlights recent development of stimuli-responsive biomaterials to reproduce the complex and dynamic microenvironment of the native heart for cardiac tissue engineering and dynamic mechanobiology studies.
Syracuse University
Since the term “smart materials” was put forward in the 1980s, stimuli-responsive biomaterials have been used as powerful tools in tissue engineering, mechanobiology, and clinical applications. For...
The review summarizes the deficiencies and advantages of various existing wound dressings, and outlines the recent advances, challenges and future perspectives of high-performance hydrogel wound dressings.
Severe hemorrhage is a leading cause of high mortality in critical situations like disaster, accidents, and warfare. The resulting wounds could induce severe physical and psychological trauma to pa...
FRESH 3D-Printing Platform Paves Way for Tissues, Organs - AIP Publishing LLC
Link to article: Emergence of FRESH 3D printing as a platform for advanced tissue biofabrication DOI: 10.1063/5.0032777 WASHINGTON, February 16, 20...
Hydrogel Promotes Wound Healing Better Than Traditional Bandages, Gauzes - AIP Publishing LLC
Link to article: Recent advances on polymeric hydrogels as wound dressings DOI: 10.1063/5.0038364 WASHINGTON, February 16, 2021 — The widespread us...
Biomaterials Could Mean Better Vaccines, Virus-Fighting Surfaces - AIP Publishing LLC
Link to article: Biomaterials-based formulations and surfaces to combat viral infectious diseases DOI: 10.1063/5.0029486 WASHINGTON, February 9, 20...
Cancer Research Expands Body's Own Immune System to Kill Tumors - AIP Publishing LLC
Link to article: Perspective: Modeling the tumor immune microenvironment for drug discovery using 3D culture DOI: 10.1063/5.0030693 WASHINGTON, Feb...
Characterization of an in-gel polymerase elongation process revealed that DNA polymerase diffusion was impeded by molecular interactions with immobilized DNA. This finding will inform design of gel-based assays.
UC Berkeley
Fluorescence-based DNA readouts are increasingly important in biological research, owing to enhanced analytical sensitivity and multiplexing capability. In this study, we characterize an in-gel pol...
Check our latest in APL Bioengineering by @MJMitchell_Lab @pennbioeng on peptide functionalized liposomes for receptor targeted cancer therapy!
University of Pennsylvania
Most clinically approved cancer therapies are potent and toxic small molecules that are limited by severe off-target toxicities and poor tumor-specific localization. Over the past few decades, atte...
In response to injury, endothelial cells and fibroblasts within an engineered 3D vascularized tissue dynamically contract the wound, migrate, and distribute matrix to close the void.
Boston University College of Engineering
Boston University
The formation of healthy vascularized granulation tissue is essential for rapid wound closure and the prevention of chronic wounds in humans, yet how endothelial cells and fibroblasts coordinate du...
This perspective by Alana Welm and colleagues outlines the challenges of modeling the complexities of cancer and new progress toward improved in vivo models to advance therapeutic development.
The University of Utah
Human cancer is a complex and heterogeneous collection of diseases that kills more than 18 million people every year worldwide. Despite advances in detection, diagnosis, and treatments for cancers,...
Microrheology is a versatile tool for material characterization. Its use as a tool in designing biomaterials as physiological models, tissue engineering scaffolds, and therapeutic delivery vehicles are described in this new review in APL Bioengineering.
University of Maryland
Microrheology analyzes the microscopic behavior of complex materials by measuring the diffusion and transport of embedded particle probes. This experimental method can provide valuable insight into...
How can we use DNA nanostructures to probe cellular membranes? Here researchers review DNA nanotechnology, membrane biophysics, delivery strategies and recent advances in applications for DNA nanotechnology at the membrane interface.
Carnegie Mellon University Carnegie Mellon Mechanical Engineering Department
CMU Physics Department
DNA nanotechnology has proven exceptionally apt at probing and manipulating biological environments as it can create nanostructures of almost arbitrary shape that permit countless types of modifica...
COVID-19 can be diagnosed by several tests like molecular-, immuno-, and nano-based assays. However, it is an urgent requirement to discover more sensitive, specific, fast, and accurate tests.
Yıldız Teknik Üniversitesi
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent responsible for the coronavirus disease of 2019 (COVID-19), which triggers lung failure, pneumonia, and multi-organ dysfunc...
Metastatic cells navigate heterogeneous tumor microenvironments. Insights from computational models of migration modes with implications on metastasis are discussed and open questions are highlighted.
UC San Diego
Tumor cells migrate through changing microenvironments of diseased and healthy tissue, making their migration particularly challenging to describe. To better understand this process, computational ...
Understanding cell-light/polymer interactions is crucial in light-based bioprinting. Theoretical mechanisms, which condition cell response and the parameters essential for maintaining cell viability are summarized.
Biofabrication technologies that use light for polymerization of biomaterials have made significant progress in the quality, resolution, and generation of precise complex tissue structures. In rece...
Emergence of functional neuromuscular junctions in an engineered, multicellular spinal cord-muscle bioactuator
Three-dimensional (3D) biomimetic systems hold great promise for the study of biological systems in vitro as well as for the development and testing of pharmaceuticals. Here, we test the hypothesis...
Nanostructured carriers as innovative tools for cancer diagnosis and therapy
Cancer accounts for millions of deaths every year and, due to the increase and aging of the world population, the number of new diagnosed cases is continuously rising. Although many progresses in e...
Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy
Exosomes are small (∼30–140 nm) lipid bilayer-enclosed particles of endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most cell types. There has been growing ...
Out of Many COVID-19 Tests, Which One to Choose? - AIP Publishing LLC
Link to article: Evaluation of current diagnostic methods for COVID-19 DOI: 10.1063/5.0021554 WASHINGTON, December 1, 2020 — Until a vaccine is ava...
Bactericidal activity of 3D-printed hydrogel dressing loaded with gallium maltolate
Chronic wounds are projected to reach epidemic proportions worldwide because of the aging population and the increasing incidence of diabetes. Despite extensive research, infection remains one of t...
Using DNA labels gives biological assays an edge
Fluorescence-based DNA bioanalyses have many advantages, as long as you let the reaction run to completion.
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