10/06/2026
Behind the headline-grabbing name are PDRN and PN, purified fish DNA fragments that dermatologists say may calm inflammation, support repair and boost collagen. Injections aren’t yet legal in the U.S., so practitioners here apply Rejuran topically after microneedling instead.
In Seoul, former Allure editor-in-chief Michelle Lee went all in with 70 Rejuran injections and came out with skin she called “plumped” and “poreless.” Vogue now ranks polynucleotides among aesthetics’ biggest success stories.
Fishy name. Serious skin. Would you try it?
Results vary. Consult a board-certified dermatologist.
SkinQuality Aesthetics