07/26/2025
U.S. Route 27 is a north–south highway that runs through the Southern and Midwestern U.S., starting all the way down in Miami, Florida, and ending in Fort Wayne, Indiana, where it meets up with I-69. From Miami, it cuts up through central Florida, swings west over to Tallahassee, and then heads north through a bunch of cities and towns like Columbus and Rome in Georgia, Chattanooga in Tennessee, Lexington and other parts of Kentucky, Cincinnati and Oxford in Ohio, then into Indiana through Richmond before ending in Fort Wayne. It used to go even farther north into Michigan—through Lansing and up to Cheboygan and Mackinaw City—and for a short time, it even stretched all the way to St. Ignace.
In Florida, the highway is named the Claude Pepper Memorial Highway, in honor of the longtime U.S. Senator and Representative. The part from Miami to South Bay was earlier named the Thomas E. Will Memorial Highway, named after the guy who helped push for the road to be built near Lake Okeechobee. Almost all of US 27 in Florida is a divided highway.
The route starts as North 36th Street in Miami, heading west for about 4.4 miles, then swings northwest and follows South Okeechobee Road, running along the Miami Canal and past the edge of Hialeah. After passing major interchanges with SR 826 (Palmetto Expressway) and the Homestead Extension of Florida’s Turnpike (SR 821), it keeps heading northwest and eventually curves north into Broward County. There, it runs alongside wetlands and powerlines on one side and suburbs like Pembroke Pines and Weston on the other. It hits I-75 and Alligator Alley before curving northwest toward Lake Okeechobee and South Bay.
From there, it hugs the lake’s southwest shore, turns west at Clewiston, then heads north through Moore Haven and continues through Lake Placid, Sebring, Avon Park, and Lake Wales. In Polk County, the highway is being widened to six lanes in spots, with sections like SR 60 to SR 540 in Lake Wales and from SR 542 in Dundee to north of I-4 in Davenport already done.
North of I-4, it hits unnumbered interchanges with US 192, CR 474 in Four Corners, SR 50 in Clermont, and SR 19 near Howey-in-the-Hills, where it connects with Florida’s Turnpike. Later, it joins with US 441 in Leesburg and with US 301 in Belleview before splitting off again in Ocala. After Williston, it runs with US 41 up to High Springs, where US 41 merges with US 441. US 27 then heads west toward Perry and joins US 19 until it splits off again in Capps. In Tallahassee, the road becomes the Apalachee Parkway, a major route through the city that starts in front of the Florida State Capitol and runs past the Governor’s Square mall and a bunch of government buildings. Once past Tallahassee, it curves northwest again and continues into Georgia through Havana and Amsterdam.
In Georgia, US 27 is named the Martha Berry Highway, after the founder of Berry College in Rome. It’s part of the GRIP (Governor’s Road Improvement Program) and is being upgraded to a four-lane divided highway from the Florida line all the way to Tennessee. US 27 runs the whole way with Georgia State Route 1. Around Chattanooga, a section used to be called I-124, though you won’t see signs for it anymore. This stretch is also known as Corridor J in the Appalachian Development Highway System, running from Chattanooga to London, Kentucky.
Between Chattanooga and Harriman, US 27 travels through a valley between the Tennessee River and the Cumberland Plateau, with the ridge often visible to the west. The highway passes through Soddy-Daisy, where it intersects SR 111, then through towns like Sale Creek, Graysville, and Dayton. In Dayton, it connects with SR 30 and SR 60, then continues through Evensville and Spring City, where it intersects SR 68. Moving into Roane County, it shares the road with US 70 through Rockwood, then runs with SR 61 through Harriman, crossing I-40. This part is also called the Harvey H. Hannah Memorial Highway. After Harriman, the road climbs the plateau and continues north across it.
In Morgan County, US 27 passes through Wartburg and Sunbright. At Elgin, it connects with SR 52, then continues through Robbins, Huntsville, Helenwood, and into Oneida in Scott County. There, it intersects SR 297, which leads into the Big South Fork National River and Recreation Area. After a few more miles and a sharp left turn through downtown Oneida, it passes through Winfield and crosses into Kentucky near Isham.
Once in Kentucky, US 27 hits towns like Whitley City, Somerset, Stanford, Lancaster, and Nicholasville before reaching Lexington, where it runs with US 68 up to Paris. After that, it heads north through Cynthiana, Falmouth, Alexandria, Cold Spring, Highland Heights, Fort Thomas, Southgate, and Newport before crossing the Ohio River into Cincinnati via the Taylor–Southgate Bridge. From Highland Heights to much of Campbell County, and in some parts south of Lexington, US 27 is a four-lane highway. It also has four lanes near Lake Cumberland.
In Ohio, US 27 crosses into downtown Cincinnati via the Taylor–Southgate Bridge. It runs along streets like Mehring Way, Central Avenue, and Ezzard Charles Drive, and overlaps briefly with I-75 and I-74 before heading northwest on Colerain Avenue. It goes through Oxford and reaches the Indiana border near College Corner. In total, US 27 runs for about 41 miles in Ohio—almost half in Hamilton County and the rest in Butler County.
In Indiana, the route enters just south of Liberty and heads north, staying close to the Ohio state line. It hits I-70 in Richmond and continues to Decatur, where US 33 joins in. The two run together northwest to I-469 near Fort Wayne. US 33 splits off along I-469, while US 27 heads into downtown Fort Wayne on Clinton Street. After downtown, it follows Lima Road until it ends at I-69 and US 30. From there, Lima Road continues north as State Road 3.