"To elevate diverse voices, I am a big proponent of a practice from the corporate world called sponsorship — an intentional effort by people in positions of power to actively advance the careers of younger colleagues and steer them toward leadership positions. It’s basically talent management." 11 women on how to improve gender equity in medical research: https://go.nature.com/2Q6VjE8
In the absence of genital inflammation, tenofovir gel provides superior prevention against #HIV acquisition in women | go.nature.com/2DQMERi | #nationalwomenshealthweek #HIVprevention
This month's editorial is about the future of HIV vaccines | go.nature.com/2VkWaXI
A new non-invasive #prenataltest that simultaneously detects mutations in 30 genes frequently associated with dominant #monogenicdiseases demonstrates high accuracy in clinical samples | go.nature.com/2sZS86N |#nationalwomenshealthweek
Scientists have repaired a gene error associated with #cysticfibrosis in utero in a mouse model of the disease - the findings suggest that gene editing might be used in this way one day to treat disease before birth https://go.nature.com/2WN19NH
A pick-the-winner clinical trial design in metastatic triple negative #breastcancer patients shows immune induction with #chemotherapy improves clinical responses to #PD-1 blockade| go.nature.com/2Q5gjLv | @NKI_nl
"One frequent observation about pulmonary tuberculosis is that its incidence in some high-burden areas is close to twice as high in men than in women..."|Read more at go.nature.com/2Vo8y9H | #nationalwomenshealthweek #tuberculosis
#Brain region-specific #RNAseq from humans with major depressive disorder reveals unique transcriptomic profiles in males and females | go.nature.com/2WrqIUk |#depression #nationalwomenshealthweek
There are interesting ideas emerging at the intersection of two important fields in biomedicine: #geneediting and #stemcell science. Read about how researchers are combining these technologies to battle illnesses such as #SickleCell disease: https://go.nature.com/2HklzrT
"To elevate diverse voices, I am a big proponent of a practice from the corporate world called sponsorship — an intentional effort by people in positions of power to actively advance the careers of younger colleagues and steer them toward leadership positions. It’s basically talent management." 11 women on how to improve gender equity in medical research: https://go.nature.com/2Jrel83
Inhibiting VCAM1 signaling at the blood-brain barrier attenuates #aging-induced cognitive dysfunction in mice | go.nature.com/2Yp5w1C | @wysscoray #microglia #neurogenesis
Excess anti-Müllerian hormone during #pregnancy results in polycystic ovary syndrome-like phenotypes in female offspring | go.nature.com/2IjtZCf | #PCOS #nationalwomenshealthweek
Systematic #metabolite profiling across #cancer cell lines uncovers patterns associated with genetic and epigenetic features and reveals dysregulated metabolic states that can be exploited for anti-cancer therapy | go.nature.com/2Vfbalg | @broadinstitute
Period-tracking apps offer new insights on women’s health | go.nature.com/2V1Lf01 | #nationalwomenshealthweek
Personalized Omics profiling can lead to actionable health discoveries and stimulate lifestyle changes | go.nature.com/2PW1ew0 | @Snyder_Lab_SU
It's #NationalWomensHealthWeek and we will be highlighting some of our recent relevant content over the next few days! First up -- check out this article on how early-life complications modulate the association of genomic risk and #schizophrenia | go.nature.com/2snJwGd
#Masscytometry identifies a unique phenotype enriched in CD4+ T cells isolated from #autoimmunedisease patients. #celiacdisease https://go.nature.com/2JEm4jX
Acceleration of early-stage concepts to the clinic must be maintained for the successful treatment and prevention of #HIV. Check out our May @NatureMedicine #Editorial | go.nature.com/2VkWaXI
Prospects and limitations in the current approaches to #probiotic research in this Perspective from @EranElinav @nivzmora @segal_eran @JothamSuez #microbiome go.nature.com/2V9D6XK
Our May issue is live! go.nature.com/2H90ctx
First clinical use of engineered bacteriophages for the treatment of disseminated mycobacterial infection | go.nature.com/2GOvwwe @GHatfull @DrHelenSpencer
First clinical use of engineered bacteriophages for the treatment of disseminated mycobacterial infection | go.nature.com/2GOvwwe @GHatfull @DrHelenSpencer
Elevated methionine cycle activity is essential for cancer #stemcell tumorigenesis and represents a therapeutic vulnerability | https://go.nature.com/2H0xcmI
Human 3D brain #organoids identify intermediate progenitor dysfunction in a model of premature hypoxia | go.nature.com/2VAhl7C @PascaStanford #stemcells #development
We asked 10 female #STEM thought leaders from around the world for ideas on how to address gender inequality in medical research. Check out what they had to say! @Etravistravis @MosquedaMD @LBMicro @jessicapolka #WomeninSTEM go.nature.com/2VC8wtR
Recent study in @NEJM shows that human survivors of #Ebola virus disease are more likely than uninfected controls to develop memory loss, uveitis, and other abnormal conditions, and Ebola virus remains in semen much longer than previously thought go.nature.com/2GTY48T
A new analysis of #medicalrecords of 1.8 million pregnant Swedish women and their children found that infection diagnosed in a pregnant woman during a hospitalization increased the risk in her child of developing #depression or #autism later in life #NMEDHighlight | go.nature.com/2ISLhG3 & ja.ma/2vzg7us | @JAMAPsych
Three innovative #precisionmedicine studies show the utility of evidence beyond that from tumor DNA sequencing to guide therapy in patients with #cancer. https://go.nature.com/2V5YKB0
GITR agonism can be exploited in combination with checkpoint blockade to overcome immune refractoriness in solid tumors | go.nature.com/2UNVXqP @sloan_kettering #Immunotherapy
Researchers @harvardmed develop a robust signature of circulating inflammatory proteins that is causally associated with 10-year risk of progression to end-stage renal disease in #diabetic patients | go.nature.com/2vlrbvk @JoslinDiabetes #biomarkers
For #ParkinsonsAwarenessMonth: two papers investigating links between #Parkinsons & #Alzheimers | 2/2 Inhibition of amyloid-β plaque formation by α-synuclein rdcu.be/byzGy @UniFreiburg @DZNE_en
Fusion-proteins in tumors with low mutational burden represent functional #neoantigens that elicit #Tcell activation and mediate responses to #immunotherapy | go.nature.com/2W1kM46 @sloan_kettering
Authors from @_Hubrecht describe a biobank of ovarian #Cancer #organoids that recapitulate the histopathological & molecular hallmarks of patients and provide a resource for pre-clinical research | go.nature.com/2ZqtBXv @HansClevers #OvarianCancer
A novel system of #wireless skin-like sensors is developed for non-invasive and continuous monitoring of #neonatal vital signs in intensive care units #NMEDHighlight | go.nature.com/2XDbpbq & bit.ly/2GDX6gX @sciencemagazine @NorthwesternEng
A novel anti-CD19 CAR T cell therapy induces potent anti-tumor responses without causing severe cytokine release syndrome or neurotoxicity in lymphoma patients | go.nature.com/2IAxvrA @KeckMedUSC #Immunotherapy
A prospective clinical study of #cancer patients demonstrates the feasibility of matching genomic alterations found in tumors to combined drug treatments | go.nature.com/2GCEjCV #PrecisionMedicine #clinicaltrials @JasonSicklick @Dr_R_Kurzrock @UCSDHealth
Data from @WIN_Consortium demonstrate the potential of #transcriptomics to expand the proportion of #Cancer patients eligible for personalized care | go.nature.com/2DpZyFZ #PrecisionMedicine #clinicaltrials @jsoriamd @rschilsky @MDAndersonNews @Dr_R_Kurzrock @UCSDHealth
Molecular profiles based on #ctDNA sequencing inform treatment decisions for #cancer patients in early phase clinical trials, from Caroline Dive and colleagues @CRUK_MI | go.nature.com/2GzP4FZ
In three new studies published today, molecular profiling strategies are used to guide #PrecisionMedicine cancer therapies in the TARGET, I-PREDICT and WINTHER #clinicaltrials
Mitchell Elkind @Columbia discusses results of a recent study showing divergent effects of #cholesterol lipids on risk for ischemic and hemorrhagic #stroke in this N&V from our current issue | go.nature.com/2PkyOvk
A new protocol to rapidly derive kidney #organoids from adult #StemCells (even from human urine) is reported @NatureBiotech to model kidney disease, infections & response to therapy #NMEDHighlight | go.nature.com/2ZmK26T & go.nature.com/2V7FamP @HansClevers @_Hubrecht
Reporting @NPR confirms that 2 U.S. patients have begun treatment that includes #CRISPR-edited autologous #TCell therapy #NMedNewsBeat https://n.pr/2UmwO6s
This could be a crucial year for the powerful gene-editing technique CRISPR as researchers start testing it in patients to treat diseases such as cancer, blindness and sickle cell disease.
Work reporting a new drug to restore intestinal barrier dysfunction in rodent models of #IBD and #Crohnsdisease is covered in this N&V by Julie Magarian Blander in our April issue | go.nature.com/2v5Uzpn
The breast milk #microbiome is influenced by both maternal factors and the child’s oral microbiome, data from ~ 400 infant-mother pairs in the Infant and Child Studies Project at Binghamton University @cellhostmicrobe #NMEDHighlight | go.nature.com/2GdfVGf & bit.ly/2T4h1wx @MeghanAzad @ShirinMoossavi
The number of U.S. scientists with prior knowledge of the controversial human germline genome editing experiments continues to grow, and now at least one is facing a university investigation @nytimes |#NMEDNewsBeat https://nyti.ms/2PaOroU
Stanford is investigating Stephen Quake’s interactions with He Jiankui, the scientist who performed the controversial experiment.
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Authors from @_Hubrecht describe a biobank of ovarian #Cancer #organoids that recapitulate the histopathological & molecular hallmarks of patients and provide a resource for pre-clinical research | go.nature.com/2ZqtBXv @HansClevers #OvarianCancer
Efficient #GeneEditing in human stem cells to restore hemoglobin function in blood disorders like #SickleCell disease. @danielevanbauer https://go.nature.com/2Wm7grt
The video below shows intestinal organoids derived from a patient with cystic fibrosis swelling in response to a drug for the disease. The swelling indicates the drug is likely to work when given to the patient. Increasingly, such organoids are being used to inform treatment. Read more in our feature story: http://go.nature.com/2uQZ31z
When viruses enter cancer cells, the cells break open & die. The video below shows the viruses (in green) taking over lung cancer cells. Now these viruses are being used to target metastatic cancers. More in our story: http://go.nature.com/2r3BMpW
ICYMI: How the smallest MRI machine of its kind is offering a look into the developing brain: http://go.nature.com/2nnu6xH
Advancements in MRI technology are giving us an unprecedented look into the developing fetal brain. Read more in our story here: http://go.nature.com/2m2AWIE
Scientists at Tufts University have created an organoid-based model that mimics the human intestine. Read how they plan to use it to study infectious diseases: http://go.nature.com/2iaudgc
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