Nature Medicine

08/20/2025

RESEARCH

5y follow up from the phase 3 KEYNOTE426 trial show that pembrolizumab + axitinib vs sunitinib as 1st line shows overall & progression free survival benefits in patients with advanced clear cell renal cell carcinoma.

At the first interim analysis of the phase 3 KEYNOTE-426 trial, first-line pembrolizumab plus axitinib showed superior overall survival (OS),...

08/20/2025

RESEARCH

In the multicenter phase 2 OptiTROP-Lung01 trial in patients with treatment naive advanced non-small cell lung cancers, sacituzumab tirumotecan with anti-PDL1 tagitanlimab was safe & showed clinical efficacy.

Sacituzumab tirumotecan (sac-TMT, also known as MK-2870 or SKB264) is an antibody–drug conjugate targeting trophoblast cell surface antigen 2. We...

08/19/2025

🔆AUGUST ISSUE 🔆

Read about from the Global Neurodegeneration Proteomics Consortium (GNPC), which provide insights into changes and potential & drug targets for neurodegenerative diseases.



https://www.nature.com/nm/volumes/31/issues/8

08/13/2025

Unique biological, exposomal, economic, and sociocultural factors shape and across the globe.
Agustin Ibanez, Chi Udeh-Momoh & colleagues discuss underlying mechanisms of resilience, measurement approaches, operationalization and research gaps.

08/13/2025

Biological and health effects of fire smoke exposure:
A new study leverages powerful techniques to analyze immune dysregulation in smoke-exposed individuals, offering crucial insights for the development of novel diagnostics and interventions.
Read the News & Views from Katherine Zychowski & Mijung Oh

A new study leverages powerful multi-omics techniques to analyze immune dysregulation in smoke-exposed individuals, offering crucial insights for...

08/12/2025

Strengthening Africa’s and economic :
In our latest Perspective, authors present a five-year action plan that prioritizes high-impact, practical interventions in brain health across six key areas — to safeguard the continent’s health and economic stability alongside projected demographic shifts.

The authors present a 5-year action plan that prioritizes high-impact, practical interventions in brain health across six key areas—to safeguard...

08/12/2025

The economics of investing in women and health:
Our latest Review from Beverly Essue, & colleagues explores the intrinsic returns that would stem from comprehensive, gender-responsive investments in the health of women, by allowing full access to education and fair labour force participation – and wider benefits for communities and societies.

Investments in women and their health hold transformative potential, serving as powerful drivers of gender equality, poverty reduction, equity and...

08/12/2025

The phase 2 TUXEDO-3 trial identifies the HER3-targeting patritumab deruxtecan as a promising new therapeutic option for patients with from solid tumors.
Carey Anders & colleagues discuss the study and its implications.

The phase 2 TUXEDO-3 trial identifies the HER3-targeting antibody–drug conjugate patritumab deruxtecan as a promising new therapeutic option for...

08/01/2025

Polygenic scores for BMI and obesity constructed using data from 5M individuals with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood

07/31/2025

In an updated report on 70 laboratory-confirmed highly pathogenic avian H5N1 cases in the US between March 2024-April 2025, the absence of human to human transmission to date is confirmed, with no known mutations of resistance to neuroaminidase inhibitors.

07/31/2025

In a phase 1b trial in 3 patients with Fanconi anemia, an irradiation and busulfan-free conditioning regimen containing an anti-CD117 antibody, combined with T- and B-cell depleted haploidentical hematopoietic stem cell transplant, was safe and led to high levels of engraftment.