Nature Medicine

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"To elevate diverse voices, I am a big proponent of a practice from the corporate world called sponsorship — an intent...
05/18/2019

"To elevate diverse voices, I am a big proponent of a practice from the corporate world called sponsorship — an intentional effort by people in positions of power to actively advance the careers of younger colleagues and steer them toward leadership positions. It’s basically talent management." 11 women on how to improve gender equity in medical research: https://go.nature.com/2Q6VjE8

05/17/2019

In the absence of genital inflammation, tenofovir gel provides superior prevention against #HIV acquisition in women | go.nature.com/2DQMERi | #nationalwomenshealthweek #HIVprevention

This month's editorial is about the future of HIV vaccines | go.nature.com/2VkWaXI
05/16/2019

This month's editorial is about the future of HIV vaccines | go.nature.com/2VkWaXI

A new non-invasive #prenataltest that simultaneously detects mutations in 30 genes frequently associated with dominant #...
05/16/2019

A new non-invasive #prenataltest that simultaneously detects mutations in 30 genes frequently associated with dominant #monogenicdiseases demonstrates high accuracy in clinical samples | go.nature.com/2sZS86N |#nationalwomenshealthweek

Scientists have repaired a gene error associated with #cysticfibrosis in utero in a mouse model of the disease - the fin...
05/16/2019

Scientists have repaired a gene error associated with #cysticfibrosis in utero in a mouse model of the disease - the findings suggest that gene editing might be used in this way one day to treat disease before birth https://go.nature.com/2WN19NH

A pick-the-winner clinical trial design in metastatic triple negative #breastcancer patients shows immune induction with...
05/16/2019

A pick-the-winner clinical trial design in metastatic triple negative #breastcancer patients shows immune induction with #chemotherapy improves clinical responses to #PD-1 blockade| go.nature.com/2Q5gjLv | @NKI_nl

"One frequent observation about pulmonary tuberculosis is that its incidence in some high-burden areas is close to twice...
05/15/2019

"One frequent observation about pulmonary tuberculosis is that its incidence in some high-burden areas is close to twice as high in men than in women..."|Read more at go.nature.com/2Vo8y9H | #nationalwomenshealthweek #tuberculosis

#Brain region-specific #RNAseq from humans with major depressive disorder reveals unique transcriptomic profiles in male...
05/15/2019

#Brain region-specific #RNAseq from humans with major depressive disorder reveals unique transcriptomic profiles in males and females | go.nature.com/2WrqIUk |#depression #nationalwomenshealthweek

There are interesting ideas emerging at the intersection of two important fields in biomedicine: #geneediting and #stemc...
05/15/2019

There are interesting ideas emerging at the intersection of two important fields in biomedicine: #geneediting and #stemcell science. Read about how researchers are combining these technologies to battle illnesses such as #SickleCell disease: https://go.nature.com/2HklzrT

"To elevate diverse voices, I am a big proponent of a practice from the corporate world called sponsorship — an intent...
05/15/2019

"To elevate diverse voices, I am a big proponent of a practice from the corporate world called sponsorship — an intentional effort by people in positions of power to actively advance the careers of younger colleagues and steer them toward leadership positions. It’s basically talent management." 11 women on how to improve gender equity in medical research: https://go.nature.com/2Jrel83

Inhibiting VCAM1 signaling at the blood-brain barrier attenuates #aging-induced cognitive dysfunction in mice | go.natur...
05/15/2019

Inhibiting VCAM1 signaling at the blood-brain barrier attenuates #aging-induced cognitive dysfunction in mice | go.nature.com/2Yp5w1C | @wysscoray #microglia #neurogenesis

Excess anti-Müllerian hormone during #pregnancy results in polycystic ovary syndrome-like phenotypes in female offsprin...
05/14/2019

Excess anti-Müllerian hormone during #pregnancy results in polycystic ovary syndrome-like phenotypes in female offspring | go.nature.com/2IjtZCf | #PCOS #nationalwomenshealthweek

Systematic #metabolite profiling across #cancer cell lines uncovers patterns associated with genetic and epigenetic feat...
05/14/2019

Systematic #metabolite profiling across #cancer cell lines uncovers patterns associated with genetic and epigenetic features and reveals dysregulated metabolic states that can be exploited for anti-cancer therapy | go.nature.com/2Vfbalg | @broadinstitute

Period-tracking apps offer new insights on women’s health | go.nature.com/2V1Lf01 | #nationalwomenshealthweek
05/13/2019

Period-tracking apps offer new insights on women’s health | go.nature.com/2V1Lf01 | #nationalwomenshealthweek

Personalized Omics profiling can lead to actionable health discoveries and stimulate lifestyle changes | go.nature.com/2...
05/13/2019

Personalized Omics profiling can lead to actionable health discoveries and stimulate lifestyle changes | go.nature.com/2PW1ew0 | @Snyder_Lab_SU

It's #NationalWomensHealthWeek and we will be highlighting some of our recent relevant content over the next few days! F...
05/13/2019

It's #NationalWomensHealthWeek and we will be highlighting some of our recent relevant content over the next few days! First up -- check out this article on how early-life complications modulate the association of genomic risk and #schizophrenia | go.nature.com/2snJwGd

#Masscytometry identifies a unique phenotype enriched in CD4+ T cells isolated from #autoimmunedisease patients. #celiac...
05/10/2019

#Masscytometry identifies a unique phenotype enriched in CD4+ T cells isolated from #autoimmunedisease patients. #celiacdisease https://go.nature.com/2JEm4jX

Acceleration of early-stage concepts to the clinic must be maintained for the successful treatment and prevention of #HI...
05/09/2019

Acceleration of early-stage concepts to the clinic must be maintained for the successful treatment and prevention of #HIV. Check out our May @NatureMedicine #Editorial | go.nature.com/2VkWaXI

Prospects and limitations in the current approaches to #probiotic research in this Perspective from @EranElinav @nivzmor...
05/09/2019

Prospects and limitations in the current approaches to #probiotic research in this Perspective from @EranElinav @nivzmora @segal_eran @JothamSuez #microbiome go.nature.com/2V9D6XK

Our May issue is live! go.nature.com/2H90ctx
05/08/2019

Our May issue is live! go.nature.com/2H90ctx

First clinical use of engineered bacteriophages for the treatment of disseminated mycobacterial infection | go.nature.co...
05/08/2019

First clinical use of engineered bacteriophages for the treatment of disseminated mycobacterial infection | go.nature.com/2GOvwwe @GHatfull @DrHelenSpencer

First clinical use of engineered bacteriophages for the treatment of disseminated mycobacterial infection | go.nature.co...
05/08/2019

First clinical use of engineered bacteriophages for the treatment of disseminated mycobacterial infection | go.nature.com/2GOvwwe @GHatfull @DrHelenSpencer

Elevated methionine cycle activity is essential for cancer #stemcell tumorigenesis and represents a therapeutic vulnerab...
05/07/2019

Elevated methionine cycle activity is essential for cancer #stemcell tumorigenesis and represents a therapeutic vulnerability | https://go.nature.com/2H0xcmI

Human 3D brain #organoids identify intermediate progenitor dysfunction in a model of premature hypoxia |  go.nature.com/...
05/06/2019

Human 3D brain #organoids identify intermediate progenitor dysfunction in a model of premature hypoxia | go.nature.com/2VAhl7C @PascaStanford #stemcells #development

We asked 10 female #STEM thought leaders from around the world for ideas on how to address gender inequality in medical ...
05/02/2019

We asked 10 female #STEM thought leaders from around the world for ideas on how to address gender inequality in medical research. Check out what they had to say! @Etravistravis @MosquedaMD @LBMicro @jessicapolka #WomeninSTEM go.nature.com/2VC8wtR

Recent study in @NEJM shows that human survivors of #Ebola virus disease are more likely than uninfected controls to dev...
05/02/2019

Recent study in @NEJM shows that human survivors of #Ebola virus disease are more likely than uninfected controls to develop memory loss, uveitis, and other abnormal conditions, and Ebola virus remains in semen much longer than previously thought go.nature.com/2GTY48T

A new analysis of #medicalrecords of 1.8 million pregnant Swedish women and their children found that infection diagnose...
05/01/2019

A new analysis of #medicalrecords of 1.8 million pregnant Swedish women and their children found that infection diagnosed in a pregnant woman during a hospitalization increased the risk in her child of developing #depression or #autism later in life #NMEDHighlight | go.nature.com/2ISLhG3 & ja.ma/2vzg7us | @JAMAPsych ‏

Three innovative #precisionmedicine studies show the utility of evidence beyond that from tumor DNA sequencing to guide ...
05/01/2019

Three innovative #precisionmedicine studies show the utility of evidence beyond that from tumor DNA sequencing to guide therapy in patients with #cancer. https://go.nature.com/2V5YKB0

GITR agonism can be exploited in combination with checkpoint blockade to overcome immune refractoriness in solid tumors ...
04/29/2019

GITR agonism can be exploited in combination with checkpoint blockade to overcome immune refractoriness in solid tumors | go.nature.com/2UNVXqP @sloan_kettering #Immunotherapy

Researchers @harvardmed develop a robust signature of circulating inflammatory proteins that is causally associated with...
04/25/2019

Researchers @harvardmed develop a robust signature of circulating inflammatory proteins that is causally associated with 10-year risk of progression to end-stage renal disease in #diabetic patients | go.nature.com/2vlrbvk @JoslinDiabetes #biomarkers

For #ParkinsonsAwarenessMonth: two papers investigating links between #Parkinsons & #Alzheimers | 2/2 Inhibition of amyl...
04/25/2019

For #ParkinsonsAwarenessMonth: two papers investigating links between #Parkinsons & #Alzheimers | 2/2 Inhibition of amyloid-β plaque formation by α-synuclein rdcu.be/byzGy @UniFreiburg @DZNE_en

Fusion-proteins in tumors with low mutational burden represent functional #neoantigens that elicit #Tcell activation and...
04/25/2019

Fusion-proteins in tumors with low mutational burden represent functional #neoantigens that elicit #Tcell activation and mediate responses to #immunotherapy | go.nature.com/2W1kM46 @sloan_kettering

04/24/2019
cancer organoids

Authors from @_Hubrecht describe a biobank of ovarian #Cancer #organoids that recapitulate the histopathological & molecular hallmarks of patients and provide a resource for pre-clinical research | go.nature.com/2ZqtBXv @HansClevers #OvarianCancer

A novel system of #wireless skin-like sensors is developed for non-invasive and continuous monitoring of #neonatal vital...
04/23/2019

A novel system of #wireless skin-like sensors is developed for non-invasive and continuous monitoring of #neonatal vital signs in intensive care units #NMEDHighlight | go.nature.com/2XDbpbq & bit.ly/2GDX6gX @sciencemagazine @NorthwesternEng

A novel anti-CD19 CAR T cell therapy induces potent anti-tumor responses without causing severe cytokine release syndrom...
04/23/2019

A novel anti-CD19 CAR T cell therapy induces potent anti-tumor responses without causing severe cytokine release syndrome or neurotoxicity in lymphoma patients | go.nature.com/2IAxvrA @KeckMedUSC #Immunotherapy

A prospective clinical study of #cancer patients demonstrates the feasibility of matching genomic alterations found in t...
04/22/2019

A prospective clinical study of #cancer patients demonstrates the feasibility of matching genomic alterations found in tumors to combined drug treatments | go.nature.com/2GCEjCV #PrecisionMedicine #clinicaltrials @JasonSicklick @Dr_R_Kurzrock @UCSDHealth

Data from @WIN_Consortium demonstrate the potential of #transcriptomics to expand the proportion of #Cancer patients eli...
04/22/2019

Data from @WIN_Consortium demonstrate the potential of #transcriptomics to expand the proportion of #Cancer patients eligible for personalized care | go.nature.com/2DpZyFZ #PrecisionMedicine #clinicaltrials @jsoriamd @rschilsky @MDAndersonNews @Dr_R_Kurzrock @UCSDHealth

Molecular profiles based on #ctDNA sequencing inform treatment decisions for #cancer patients in early phase clinical tr...
04/22/2019

Molecular profiles based on #ctDNA sequencing inform treatment decisions for #cancer patients in early phase clinical trials, from Caroline Dive and colleagues @CRUK_MI | go.nature.com/2GzP4FZ

04/22/2019

In three new studies published today, molecular profiling strategies are used to guide #PrecisionMedicine cancer therapies in the TARGET, I-PREDICT and WINTHER #clinicaltrials

Mitchell Elkind @Columbia discusses results of a recent study showing divergent effects of #cholesterol lipids on risk f...
04/18/2019

Mitchell Elkind @Columbia discusses results of a recent study showing divergent effects of #cholesterol lipids on risk for ischemic and hemorrhagic #stroke in this N&V from our current issue | go.nature.com/2PkyOvk

A new protocol to rapidly derive kidney #organoids from adult #StemCells (even from human urine) is reported @NatureBiot...
04/18/2019

A new protocol to rapidly derive kidney #organoids from adult #StemCells (even from human urine) is reported @NatureBiotech to model kidney disease, infections & response to therapy #NMEDHighlight | go.nature.com/2ZmK26T & go.nature.com/2V7FamP @HansClevers @_Hubrecht

Work reporting a new drug to restore intestinal barrier dysfunction in rodent models of #IBD and #Crohnsdisease is cover...
04/16/2019

Work reporting a new drug to restore intestinal barrier dysfunction in rodent models of #IBD and #Crohnsdisease is covered in this N&V by Julie Magarian Blander in our April issue | go.nature.com/2v5Uzpn

The breast milk #microbiome is influenced by both maternal factors and the child’s oral microbiome, data from ~ 400 in...
04/15/2019

The breast milk #microbiome is influenced by both maternal factors and the child’s oral microbiome, data from ~ 400 infant-mother pairs in the Infant and Child Studies Project at Binghamton University @cellhostmicrobe #NMEDHighlight | go.nature.com/2GdfVGf & bit.ly/2T4h1wx @MeghanAzad @ShirinMoossavi

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