A platform for rapid antibody discovery enabled the isolation of hundreds of human monoclonal antibodies against SARS-CoV-2 and the prioritization of potent antibody candidates for clinical trials in patients with COVID-19. go.nature.com/3eetJPJ
The combination of nearly real-time genome sequencing of SARS-CoV-2 in infected patients during the first 10 weeks of COVID-19 containment in Australia and epidemiological modeling is helping in understanding the dynamics of the COVID-19 pandemic and potentially guiding public health decisions. go.nature.com/3fdYm9j
New study online now shows subpopulations of synovial tissue macrophages with distinctive molecular and phenotypic features may contribute to disease flare and tissue repair in patients with active rheumatoid arthritis https://www.nature.com/articles/s41591-020-0939-8 #autoimmunity
Multiple subpopulations of synovial tissue macrophages with varied transcriptional, phenotypic and functional features may contribute to disease flare and tissue repair in patients with active rheumatoid arthritis and patients in clinical remission.
This week marks our last #COVID19 Research in Brief. In our final briefing we look back and summarize some of the major scientific, medical, and global events that have shaped the past six months of #COVID19 research . Read now, free online.
go.nature.com/2Yyz8N9
The PREDICT 1 trial shows large inter-individual variations in postprandial metabolic responses to standardized meals in over 1,000 participants, demonstrating potential for development of personalized #nutrition strategies. go.nature.com/2UCgLEt
New perspective by Allison Black, Duncan R. MacCannell, Thomas R. Sibley & Trevor Bedford provides recommendations for creating an ecosystem for public health genomics that is accessible across resource settings and computational backgrounds.
go.nature.com/3i1Pupg
Spatiotemporal characterization of microbial diversity and #antibiotic resistance in a tertiary-care hospital reveals broad distribution and persistence of antibiotic-resistant organisms that could cause opportunistic infections in a healthcare setting. go.nature.com/3haApkC
Single-cell transcriptomics analysis of malignant ascites samples from patients with high-grade serous ovarian cancer reveals inter- and intra-patient heterogeneity in malignant cells, cancer-associated fibroblasts and macrophages. go.nature.com/3esvRoe
Are you attending #ISSCR2020 this week? Take a look at recent #NatureResearch stem cell papers from a developmental to clinical perspective, as selected by the Editors.
go.nature.com/2YeAoVq
Nature Medicine
Analysis of a large, single-center cohort of patients with cancer who were infected with COVID-19 uncovers factors associated with disease severity and interactions with anti-cancer therapies. go.nature.com/3euE9Mn
A systematic evaluation of the value of AI-based decision support in skin tumor diagnosis demonstrates the superiority of human–computer collaboration over each individual approach and supports the potential of automated approaches in diagnostic medicine. go.nature.com/3hTCpOu
Academic and national Biobanks are well positioned to be rapidly included into clinical workflows that provide medically actionable findings relevant for #COVID19 clinical care. Read new Correspondence by Stergachis and colleagues free online now.
go.nature.com/2V7V8Mv
A molecular analysis of tau from patients with sporadic Alzheimer’s disease reveals striking diversity in biochemical properties between patients, which influences seeding activity and correlates with the aggressiveness of the disease. go.nature.com/2Ymk596
A cell-free DNA-methylation sequencing assay accurately identifies renal cell carcinoma using plasma and urine samples. go.nature.com/2CsMl1j
A cell-free DNA-methylation sequencing assay accurately identifies different brain tumor types using plasma samples. go.nature.com/3fJLPuj
Nature Medicine summarizes all the research you need to know this week on the #COVID19 pandemic. This week, read about the GWAS study study suggesting increased risk of severe #COVID19 in people with blood group A and reduced risk with blood group O.
go.nature.com/3dh7dFm
Identification of a DNA-damage signature induced by #colibactin, a toxin expressed by some strains of Escherichia coli, is enriched in human colorectal cancers. @BiCroLabs @mpiib_berlin @helsinkiuni @IRBBarcelona #colorectalcancer #cancers
go.nature.com/3cotqB3
Our June issue is now live!! Have a look at our table of contents.
go.nature.com/3fzYDmS
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Nature Medicine
Projection of the number of COVID-19 cases and the associated burden on healthcare resources using a modified SEIR model reveals that rural regions in the United States are at risk of higher per capita case burdens, which could lead to health systems being overwhelmed in these areas. go.nature.com/3fAxXSV
A cohort of asymptomatic patients infected with SARS-CoV-2 had significantly lower levels of virus-specific IgG antibodies compared to a cohort of age- and sex-matched symptomatic infected patients. go.nature.com/3eeaPJz
On June 10, we at Nature Medicine are joining #ShutdownStem #shutdownacademia #strike4blacklives in the call for a profound and meaningful change to systemic racism in research communities. We are dedicating the day to educating ourselves and discussing what actions we can take to eradicate anti-Black racism in academia and STEM. Read more about this initiative at https://www.shutdownstem.com/resources
Resources As scientists and academics, we know that in order to solve a problem, we first need to understand it. This is just as true for structural racism and anti-Blackness! It’s also important for non-Black folks to not rely on Black folks for this education. Select your track below!I am….....
New comment calling for the formation of an international consortium to create a unified platform for global epidemiological data collection and analysis. This includes integrating global self-reported data about #COVID19 symptoms, while protecting participant privacy.
go.nature.com/307lulr
A new approach for whole-genome sequencing of plasma circulating tumor DNA allows for dynamic monitoring of disease burden and ultra-sensitive detection of minimal residual disease. https://go.nature.com/2Mj4EI6
An IgG-cleaving endopeptidase can degrade circulating anti-adeno-associated virus antibodies in mice and nonhuman primates in vivo, as well as in human plasma in vitro, offering a potential solution for a major hurdle in gene therapy. go.nature.com/3cmSHvz
Artificial intelligence algorithms integrating chest computed tomography scans and clinical information can diagnose COVID-19 with similar accuracy as compared to a senior radiologist. go.nature.com/2zPyOje
A pooled genetic, transcriptomic and immunopathologic analysis of over 500 tumors from patients with advanced renal cell cancer suggests that response to PD-1 blockade depends on both CD8+ T cell infiltration and enrichment of tumor-intrinsic somatic alterations.
go.nature.com/3deLIWT
There is a concerning lack of drug safety data for pregnant people, with prescriptive behaviors often guided by conflicting or poorly informative results from pre-clinical studies. Read how EHRs used in targeted trials may address this issue
go.nature.com/2TNAG3a
Nature Medicine summarizes all the research you need to know this week on the #COVID19 pandemic. This week, read about the hydroxychloroquine and chloroquine study in COVID-19 patients which showed no evidence of benefit, and an increased risk of death
go.nature.com/2ApmtlR
Characterization of 200 antibodies that bind a malaria parasite protein provides insights that could enable better vaccine design. go.nature.com/36uZqSV
Multiregion spatial histology, exome and transcriptome data from patients with non-small cell lung cancer suggest that cancer subclones from immune cold regions diversify later than subclones from immune hot regions. go.nature.com/36OHaUN
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A combination of high-resolution imaging and modeling approaches facilitates the study of the mechanisms and clinical progression of non-alcoholic fatty liver disease in humans. | go.nature.com/2LKguej | @mpicbg #NAFLD
A combination of high-resolution imaging and modeling approaches facilitates the study of the mechanisms and clinical progression of non-alcoholic fatty liver disease in humans. | go.nature.com/2LKguej | @mpicbg #NAFLD
A reverse engineering approach is used to generate a miniaturized, #biomimetic model of the human ocular surface that mimics spontaneous eye blinking and is used to study dry eye disease | go.nature.com/2MyBu9i @pennbioeng
A reverse engineering approach is used to generate a miniaturized, #biomimetic model of the human ocular surface that mimics spontaneous eye blinking and is used to study dry eye disease | go.nature.com/2MyBu9i @pennbioeng
Efficient #GeneEditing in human stem cells to restore hemoglobin function in blood disorders like #SickleCell disease. @danielevanbauer https://go.nature.com/2Wm7grt
Authors from @_Hubrecht describe a biobank of ovarian #Cancer #organoids that recapitulate the histopathological & molecular hallmarks of patients and provide a resource for pre-clinical research | go.nature.com/2ZqtBXv @HansClevers #OvarianCancer
Efficient #GeneEditing in human stem cells to restore hemoglobin function in blood disorders like #SickleCell disease. @danielevanbauer https://go.nature.com/2Wm7grt
The video below shows intestinal organoids derived from a patient with cystic fibrosis swelling in response to a drug for the disease. The swelling indicates the drug is likely to work when given to the patient. Increasingly, such organoids are being used to inform treatment. Read more in our feature story: http://go.nature.com/2uQZ31z
When viruses enter cancer cells, the cells break open & die. The video below shows the viruses (in green) taking over lung cancer cells. Now these viruses are being used to target metastatic cancers. More in our story: http://go.nature.com/2r3BMpW
ICYMI: How the smallest MRI machine of its kind is offering a look into the developing brain: http://go.nature.com/2nnu6xH
Advancements in MRI technology are giving us an unprecedented look into the developing fetal brain. Read more in our story here: http://go.nature.com/2m2AWIE
Scientists at Tufts University have created an organoid-based model that mimics the human intestine. Read how they plan to use it to study infectious diseases: http://go.nature.com/2iaudgc
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