Nature Medicine

12/02/2025

A new study provides the first evidence in humans that tirzepatide modulates brain electrophysiology, with changes in low-frequency accumbens power linked to food preoccupation.

Obesity and related conditions are associated with distressing food preoccupation that often culminates in dysregulated eating behaviors....

12/02/2025

How do you measure the value of in ? How can health technology assessment, implementation and data management approaches be adapted to suit the rapidly evolving nature of genomics technologies? Our latest Review from Zornitza Stark, Ilias Goranitis & colleagues addresses these questions.

Assessing the value of genomics is key to informing evidence-based policies; this Review outlines how current approaches to health technology...

12/01/2025

In this phase 1 trial, treatment of patients with fibrolamellar hepatocellular carcinoma with a therapeutic peptide vaccine targeting the fusion kinase DNAJB1::PRKACA, which is the driver of the disease, together with nivolumab and ipilimumab, was safe and led to encouraging preliminary clinical responses and translational analysis showed activation of immune responses.

Fibrolamellar hepatocellular carcinoma (FLC) is a rare form of liver cancer affecting children and young adults that is driven by a chimeric...

11/28/2025

A combination of high resolution spatial imaging, spatial proteomics and transcriptional data reveals sparse and heterogeneous bacterial signals in gliomas and brain metastases.

Gliomas and brain metastases are associated with poor prognosis, necessitating a deeper understanding of brain tumor biology and the development of...

11/25/2025

As presented at the American Heart Association Conference 2025, patients with chest pain and without obstructive coronary artery disease benefit from treatment informed by cardiovascular magnetic resonance.

As presented at the American Heart Association Conference 2025, patients with chest pain and without obstructive coronary artery disease benefit...

11/25/2025

A phase 1/2 and a phase 3 trials testing an AAV-FIX Padua gene therapy in patients with hemophilia B in China show that the treatment was well tolerated and effective in reducing annualized bleeding rate.

Gene therapy for hemophilia B with adeno-associated virus (AAV) vector has achieved great advances over the last decade. We previously conducted a...

11/21/2025

Turning genes into medicine
A groundbreaking clinical trial of gene therapy for hemophilia B didn’t just meet expectations—it challenged them. Explore how this changed the future of genetic medicine in the latest Turning Point essay from Nature Medicine.
👉 Read here: https://ow.ly/q49w50XvVs6

The first clinical trial of a gene therapy infusion for hemophilia B revealed unexpected findings.

11/20/2025

📢 new Correspondence from Nature Medicine:
“Harnessing evidence-based solutions for climate resilience and women’s, children’s and adolescents’ health” by Rajat Khosla, Helen Clark, Soumya Swaminathan, Anders Nordström & Flavia Bustreo.
It highlights how climate action can save millions of lives while advancing equity.
Read it FREE here: https://ow.ly/kTON50XuQ1I
Let’s share and advocate for integrated climate-health solutions! 🌱💙

Discover the world’s best science and medicine | Nature.com

11/19/2025

⚡Our November issue is out! Featuring trials of for , an antibody-drug conjugate for , cardiac , an trial, discovery of microbial elements in , , , and much more - including reviews, news and opinion.
Read it here: https://www.nature.com/nm/volumes/31/issues/11