Nature Medicine

09/17/2026

Integrating numerous multimodal, patient-level biomarkers enhances the prediction of response, but generalizability is still a challenge.
News & Views from Raquel Perez-Lopez, Mireia Crispin-Ortuzar

A study shows that integrating numerous multimodal, patient-level biomarkers enhances the prediction of cancer immunotherapy response, but generalizability is still a challenge.

09/17/2026

Two trials of selective inhibitors show promise in advanced cancers with G12D mutations, signaling a transformative change in the treatment of these cancers — with potential applications across tumor types and disease stages.
News & Views from Jennifer Knox & colleagues

Two early clinical studies of selective KRASG12D inhibitors show encouraging activity in advanced cancers with G12D mutations, signaling a transformative change in the treatment landscape for RAS-driven cancers with potential applications across tumor types and stages of disease.

09/17/2026

⚡ Our September issue is live! Featuring new research on clocks, transmission, , for retinal disease diagnosis, for heart failure and much more including Reviews, News and Opinion.
Read it here:

In this issue, Jia et al. show that an artificial intelligence (AI)-based clinical decision-support system, Retina4IRD, can improve the diagnosis of...

09/16/2026

Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS relapses.

09/15/2026

An in-depth phenomic analysis of health and disease patterns from 1.9 million participants of the Our Future Health cohort reports the prevalence of health conditions and medication-use patterns compared to national UK estimates and the UK Biobank.

An in-depth phenomic analysis of health and disease patterns from 1.9 million participants of the Our Future Health cohort reports the prevalence of health conditions and medication-use patterns compared with national UK estimates and the UK Biobank.

09/15/2026

A 15-year cohort study shows that Alzheimer’s dementia risk is jointly shaped by Alzheimer’s pathology and cognitive resilience, with high resilience linked to lower risk even under greater pathology.

A 15-year cohort study shows that Alzheimer’s dementia risk is jointly shaped by Alzheimer’s pathology and cognitive resilience, with high resilience linked to lower risk, even under greater pathology.

09/14/2026

In this Comment, we argue for a global health system that recognizes and supports countries as the primary agents of action, oriented around global public goods and collective action, and served by a leaner set of global and regional institutions. We present a potential vision for the functions and....

09/11/2026

News & Views: An early assessment of the UK’s 'Our Future Health' project shows how national-scale cohorts might reshape population medicine by accelerating discovery and clinical recruitment – provided that biases are carefully measured and managed.

An early assessment of the UK’s Our Future Health project shows how national-scale cohorts may reshape population medicine by accelerating discovery and clinical recruitment, provided that selection and phenotyping biases are carefully measured and managed.