Journal of Cell Biology

Journal of Cell Biology The Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press.

Darshika Bohra and Aprotim Mazumder (TIFR Hyderabad) show that HP1 protein dynamics at damage sites differentially reg...
01/07/2026

Darshika Bohra and Aprotim Mazumder (TIFR Hyderabad) show that HP1 protein dynamics at damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. https://hubs.la/Q03ZT8sx0

Aaron Byrd, Lucas J. Marmorale, Ross Buchan et al. (The University of Arizona) conducted a yeast genome-wide screen to i...
01/07/2026

Aaron Byrd, Lucas J. Marmorale, Ross Buchan et al. (The University of Arizona) conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in cell models. They found that complex genes and the ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. https://hubs.la/Q03ZT6ZQ0

New research from Miriam Lee, Henry N. Higgs et al. (Geisel School of Medicine at Dartmouth) shows how , a key regula...
01/07/2026

New research from Miriam Lee, Henry N. Higgs et al. (Geisel School of Medicine at Dartmouth) shows how , a key regulator, is activated by calcium-calmodulin and free actin monomers. Actin-binding proteins like profilin and thymosin aren't just helpers - they directly tune INF2 activity. https://hubs.la/Q03ZT6hH0

The small Rab1 is a master regulator of traffic and . Alexander van Vliet, Sean Munro et al. (MRC Laboratory of Mol...
01/07/2026

The small Rab1 is a master regulator of traffic and . Alexander van Vliet, Sean Munro et al. (MRC Laboratory of Molecular Biology) performed a proteomic screen to identify novel Rab1 effectors, including a motor adaptor and cargo receptors for autophagy. https://hubs.la/Q03ZRd8z0

01/07/2026

IV intercellular concentrations mediate cell–cell in the tissue. New study from Jameela Almasoud, Anna Franz et al. (UCL) finds that the adipose tissue has apical-basal cell , which regulates this adhesion. https://hubs.la/Q03ZR8Zx0

Qiuyuan Yin, Chonglin Yang et al. (Yunnan University) reveal a plasma membrane-to-lysosome signaling pathway mediated by...
01/07/2026

Qiuyuan Yin, Chonglin Yang et al. (Yunnan University) reveal a plasma membrane-to-lysosome signaling pathway mediated by the non-receptor tyrosine kinase FGR and the serine/threonine kinase AKT2, which regulates TFEB/TFE3 activation for biogenesis in . https://hubs.la/Q03ZR5Kg0

01/07/2026

Viktor Karlovich Lund, Ole Kjaerulff et al. (Københavns Universitet - University of Copenhagen) reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to -1 & is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. https://hubs.la/Q03ZQ_dC0

Yaqi Li, Weiying Zhang, Zihang Wei, Anming Meng, Xiaotong Wu and colleagues (Tsinghua University) report a novel Cas9-ba...
01/07/2026

Yaqi Li, Weiying Zhang, Zihang Wei, Anming Meng, Xiaotong Wu and colleagues (Tsinghua University) report a novel Cas9-based spatiotemporal gene-editing approach in . Given the limited germline transmission efficiency of knock-in alleles in zebrafish, this system enables rapid and high-throughput genetic screening in vivo. https://hubs.la/Q03ZL8TM0

Xiao Xia Cong et al. (Zhejiang University) reveal that exportin CRM1 plays a “two birds with one stone” function by supp...
01/06/2026

Xiao Xia Cong et al. (Zhejiang University) reveal that exportin CRM1 plays a “two birds with one stone” function by suppressing NPAT condensation and exporting NPAT to regulate locus body formation. https://hubs.la/Q03ZL3cW0

Review: Siqi Deng, Qinling Qiu, Shangyu Dang, and Zhiqiang Yan summarize the physiological functions and structural basi...
01/06/2026

Review: Siqi Deng, Qinling Qiu, Shangyu Dang, and Zhiqiang Yan summarize the physiological functions and structural basis of OSCA/TMEM63 proteins, positioning them within a mechanosensitive ion channel superfamily. https://hubs.la/Q03ZL3C10

Review: Michael Worcester, Gerald Hammond et al. (Pitt School of Medicine) describe a suite of molecular tools and appro...
01/06/2026

Review: Michael Worcester, Gerald Hammond et al. (Pitt School of Medicine) describe a suite of molecular tools and approaches that can be used to probe and experimentally study . https://hubs.la/Q03ZKVc70

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