Journal of Cell Biology

10/02/2025

Join JCB Scientific Editor Gabriele Stephan at the EMBO | EMBL Symposium “Cell biology of the nucleus” during the lunchtime Meet the Editor talk Nov. 19. https://hubs.la/Q03LQfWW0

10/01/2025

JCB’s Alan Hall & Norton B. Gilula Travel Awards support attendance for undergraduates, grad students, and early-career postdocs at CellBio 2025 (Dec. 6-10) in Philadelphia! Apply by Oct. 17 👉 https://hubs.la/Q03LxbHY0

The American Society for Cell Biology

09/30/2025

Wenjing Long, Yanshan Fang et al. identify NMNAT2 as a bona fide substrate of an SCFFBXO21 E3 ligase complex that ubiquitinates NMNAT2 at K155 and promotes its turnover in neurons and reveal that Fbxo21 deficiency confers axonal protection both in vitro and in vivo. https://hubs.la/Q03Lwj9S0

09/29/2025

Dolichol-linked oligosaccharide (DLO) is the precursor for asparagine-linked protein glycosylation. Sheng-Tao Li, Tadashi Suzuki et al. (RIKEN) identify a DLO-pyrophosphatase (Llp1), which is involved in DLO homeostasis/quality control. https://hubs.la/Q03LkLSq0

09/24/2025

Kenneth Gabriel Antenor, Mojca Mattiazzi Usaj et al. (Toronto Metropolitan University) show that clathrin-mediated endocytosis becomes less efficient in aging yeast mother cells due to changes in vacuolar pH. This change alters TORC1-Npr1 signaling and slows endocytic dynamics. Restoring vacuolar acidity or modulating TORC1-Npr1 signaling preserves endocytosis, which may help maintain cellular function in aging cells. https://hubs.la/Q03KNcB40

09/24/2025

As a response to membrane damage, lysosomes can generate tubules sorted into mobile vesicles in a process called LYTL. Luis Bonet-Ponce, Mark R. Cookson et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate the dynamics of LYTL tubules. https://hubs.la/Q03KM-Np0

09/23/2025

Guus Franken, Laia Querol Cano et al. (Radboudumc) reveal that galectin-9 is a critical regulator of dendritic cell basal and chemokine-driven migration by organizing CD44 at the cell surface and promoting RhoA-GEF-H1–mediated signaling. Galectin-9 rescued the motility of tumor-immunocompromised dendritic cells, validating the physiological relevance of our data and underscoring its implications for DC-based immunotherapies. https://hubs.la/Q03KBjz10

09/23/2025

In this new Perspective, Maik Bischoff and Roberto Mayor present a framework for comparing mesenchymal collective migration modes and explain their roles in patterning and morphogenesis. https://hubs.la/Q03KB5610

09/23/2025

Morgan Miller & Sami Barmada discuss recent work from Hasegawa-Ogawa and colleagues (https://hubs.la/Q03Kyktw0), which reveals distinct mechanisms by which TDP43 and other ALS-associated RNA-binding proteins regulate the expression and activity of TDP43.
https://hubs.la/Q03Ky65b0

09/23/2025

📕 Our Intermediate Filaments collection explores recent advances in intermediate filament research, focusing on lamins, keratins and vimentin. Explore new and recent JCB studies to accompany this week's European Intermediate Filament Meeting 👉 https://hubs.la/Q03Jq13L0

09/18/2025

Peer Review Week 2025 is an opportunity to recognize the essential role reviewers play in safeguarding scientific rigor and advancing discovery. We are grateful to the expert reviewers who contribute their time, insight, and thoughtful critiques. We deeply appreciate your collaboration with authors and editors to strengthen the research we publish.

This year’s theme, "Rethinking Peer Review in the AI Era," captures what most of the industry is discussing in private and public circles about artificial intelligence. The organizers have made available a list of events and materials, and we have been exploring right alongside our peers: https://hubs.ly/Q03JZyBV0

While this week has focused on technology, we want to take a moment to thank the people behind the peer review process. Our position is that rigorous peer review demands direct accountability that only human reviewers can provide.

As a nonprofit journal, JCB will continue to approach new technologies while never losing sight of what makes us unique, which is that we are driven by people and the scientific communities we serve.

09/16/2025

Spotlight: Yameng Huang and Cynthia He (National University of Singapore) discuss recent advances from Araujo Alves et al. (https://hubs.la/Q03JxGm00), describing how intraflagellar transport trains in T. brucei selectively associate with axonemal doublet . https://hubs.la/Q03JxNvP0

In Trypanosoma brucei, IFT trains selectively associate with specific axonemal microtubules. Using advanced microscopy, Araujo Alves et al. reveal how this