Journal of Cell Biology

Journal of Cell Biology The Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press.

Yanyan Li, Hongchang Li al. reveal that Aurora A–mediated phosphorylation of Numb triggers its dissociation from the pla...
11/10/2025

Yanyan Li, Hongchang Li al. reveal that Aurora A–mediated phosphorylation of Numb triggers its dissociation from the plasma membrane, thereby promoting I–dependent membrane-to-cortex adhesion required for mitotic cell rounding https://hubs.la/Q03SqzQf0

Belén Calvo, Sandip Patel, Teresa Alonso, and colleagues (Universidad de Valladolid) describe a new bioluminescent senso...
11/07/2025

Belén Calvo, Sandip Patel, Teresa Alonso, and colleagues (Universidad de Valladolid) describe a new bioluminescent sensor for measuring luminal Ca²⁺ in a mildly acidic subcompartment of the endo-lysosomal system. https://hubs.la/Q03ScdR50

Hiroki Okada, Erfei Bi and colleagues (Perelman School of Medicine at the University of Pennsylvania) show that Bni5 int...
11/06/2025

Hiroki Okada, Erfei Bi and colleagues (Perelman School of Medicine at the University of Pennsylvania) show that Bni5 interacts with filaments, septin-associated kinase, and -II to regulate septin hourglass architecture and remodeling, retrograde flow, and https://hubs.la/Q03S2bJk0

11/06/2025

Peiyao Fan, Yang Chen et al. (Peking University) show that tubular ER extends into retraction fibers and through -dependent ER extension and ER-plasma membrane contact sites in migrating cells. https://hubs.la/Q03S214l0

11/04/2025

In new study from Samantha Ryken, Magdalena Bezanilla et al. (Dartmouth), analysis of PIIB-type calcium pump localization and function elucidates one of the molecular mechanisms that maintains the strength of the calcium gradient during polarized growth. https://hubs.la/Q03RCqmV0

Xu Liu, Ya Huang, Yong Zhang et al. (Soochow University) show that the transcriptional regulator RTF1 promotes rhythm ...
11/04/2025

Xu Liu, Ya Huang, Yong Zhang et al. (Soochow University) show that the transcriptional regulator RTF1 promotes rhythm by enhancing CLOCK occupancy and H3K4me3 deposition at pacemaker gene loci. https://hubs.la/Q03RCspZ0

11/04/2025

Desislava Glushkova, Stefanie Böhm & Martin Beck (Max Planck Society) develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations w/in & across organelles https://hubs.la/Q03RCqN00

Spotlight: Jianuo Han and Yansong Miao (Nanyang Technological University, Singapore) highlight recent findings from Magl...
11/03/2025

Spotlight: Jianuo Han and Yansong Miao (Nanyang Technological University, Singapore) highlight recent findings from Magliozzi et al. (https://hubs.la/Q03RlV460), identifying a novel “composite” nucleator for the assembly of thick actin cables. https://hubs.la/Q03RlSM_0

Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University) demonstrate that B4GALT1 and WLS cooperate to retain...
11/03/2025

Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University) demonstrate that B4GALT1 and WLS cooperate to retain the canonical receptor LRP5/6 on the apparatus, leading to specific inhibition of the Wnt/β-catenin signaling in such Wnt-receiving cells that have no expression of Wnt proteins. https://hubs.la/Q03RlV420

Localization of the is controlled by regulatory factors, membrane curvature, & charge. In this study, Brandy Curtis ...
11/03/2025

Localization of the is controlled by regulatory factors, membrane curvature, & charge. In this study, Brandy Curtis and Amy Gladfelter et al. (Duke University) find changes to composition that modulate lipid packing defects to impact septin assemblies in vitro & in cells. https://hubs.la/Q03Rlr1r0

JCB’s November issue is here! https://hubs.la/Q03QR2xQ0Cover shows a scanning electron microscopy image of a human osteo...
11/03/2025

JCB’s November issue is here! https://hubs.la/Q03QR2xQ0
Cover shows a scanning electron microscopy image of a human osteoclast derived from blood monocytes on bone slices.

Dufrançais et al. show that moesin, a member of the ERM proteins, plays a negative regulatory role in osteoclastogenesis. We unravel the importance of tunneling nanotubes in moesin-mediated osteoclast fusion and the involvement of the β3-integrin/RhoA/SLK pathway. Moesin-deficient mice are osteopenic with increased osteoclast activity.

Image © Dufrançais and Poincloux. See https://hubs.la/Q03QR2Vp0

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