Journal of Cell Biology

Journal of Cell Biology The Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press.

JCB’s December issue is here! https://hubs.la/Q03VTmMW0The cover shows a confocal image of migrating mouse fibroblast L9...
12/01/2025

JCB’s December issue is here! https://hubs.la/Q03VTmMW0
The cover shows a confocal image of migrating mouse fibroblast L929 cell overexpressing GFP-RTN4C, stained with Wheat Germ Agglutinin (WGA; cyan) to visualize the plasma membrane, retraction fibers (RFs), and migrasomes. Tubular ER is labeled by GFP-RTN4C (yellow). The image illustrates that migrasomes grow at the tips or intersections of RFs during cell migration. Meanwhile, tubular ER attaches to migrasome initiation sites to extend into RFs and migrasomes, establishing localization within RFs and migrasomes, facilitating spatially encoded signal transmission coupling cell migration. See Fan et al.: https://hubs.la/Q03VTp3c0

Spotlight: Spencer Freeman and Sergio Grinstein discuss a study from Riederer et al. (https://hubs.la/Q03VZsHt0) questio...
11/26/2025

Spotlight: Spencer Freeman and Sergio Grinstein discuss a study from Riederer et al. (https://hubs.la/Q03VZsHt0) questioning whether TMEM175 contributes to disease by serving as a pH-regulatory H⁺ channel or a K⁺ channel. https://hubs.la/Q03VZtqd0

Yang, Kong, Liu et al. report that homocysteine, an intermediate in methionine-cysteine and the cause of the life-thre...
11/25/2025

Yang, Kong, Liu et al. report that homocysteine, an intermediate in methionine-cysteine and the cause of the life-threatening disease , disrupts lysosomal functions by binding to and homocysteinylating V-ATPase. https://hubs.la/Q03VRCbx0

Congratulations to Yu Deng, the winner of JCB's 2025 Norton B. Gilula Travel Award! Yu is a PhD student from Dr. Peter D...
11/24/2025

Congratulations to Yu Deng, the winner of JCB's 2025 Norton B. Gilula Travel Award! Yu is a PhD student from Dr. Peter Devreotes’ lab at Johns Hopkins School of Medicine. Be sure to catch Yu’s talk during ! Read about this year's winners: https://hubs.la/Q03VDFyr0

Congratulations to Justus Francis, the winner of 2025 Alan Hall Travel Award! Justus is a graduate student in the lab of...
11/24/2025

Congratulations to Justus Francis, the winner of 2025 Alan Hall Travel Award! Justus is a graduate student in the lab of Saikat Chowdhury at the CSIR-Centre for Cellular and Molecular Biology. Be sure to catch Justus’s talk during !
Read about this year's winners: https://hubs.la/Q03VDGL70

Shuai Liu, Shan Li and colleagues (Huazhong Agricultural University) discover that pathogenic bacteria use a shared stra...
11/21/2025

Shuai Liu, Shan Li and colleagues (Huazhong Agricultural University) discover that pathogenic bacteria use a shared strategy to exploit the host’s cellular recycling process, . Through an effector protein that acts as an external receptor, bacteria suppress inflammatory responses to promote https://hubs.la/Q03Vr33h0

Xingchen Li, Christoph Ballestrem, et al. (The University of Manchester) show that multidomain interactions between tali...
11/21/2025

Xingchen Li, Christoph Ballestrem, et al. (The University of Manchester) show that multidomain interactions between talin and tensin3 regulate activity, fibrillar formation, assembly, and mechanosensitive tensin3 phase separation. https://hubs.la/Q03Vr2hC0

📢 Attention attendees! TODAY at 12:10 - 1:40 pm (CET): Join JCB Scientific Editor Gabriele Stephan at the Meet the Edi...
11/20/2025

📢 Attention attendees! TODAY at 12:10 - 1:40 pm (CET): Join JCB Scientific Editor Gabriele Stephan at the Meet the Editor session during lunchtime! https://hubs.la/Q03NXnht0

11/19/2025

Tianqi Wang, Daniel H. Kim, Chang Ding et al. of the Qing Deng lab (Purdue University) demonstrate that inward-rectifying potassium channels maintain the resting membrane potential and are required for directional sensing during chemotaxis. It is a novel molecular mechanism by which bioelectricity regulates cell migration without affecting overall cell motility. The work is significant, given the high importance of immune cell migration in health and disease. https://hubs.la/Q03V1Pcq0

Nicolas Joly and Lionel Pintard (Institut Jacques Monod) uncover how the enzyme Katanin avoids wasting energy during mic...
11/19/2025

Nicolas Joly and Lionel Pintard (Institut Jacques Monod) uncover how the enzyme Katanin avoids wasting energy during microtubule remodeling. Their findings reveal how Katanin couples activation to microtubule binding, preventing futile ATP consumption and providing insights relevant to cell biology and disease. https://hubs.la/Q03V1P8p0

In this Tools article, Cao, Peng, and Yang et al. from Huazhong Agricultural University present a high-content image-bas...
11/17/2025

In this Tools article, Cao, Peng, and Yang et al. from Huazhong Agricultural University present a high-content image-based phenotyping pipeline for quantitative analysis of organelle morphology. The interpretable feature-based method detects both prominent and subtle phenotypic changes and uncovers Golgi-cilia dynamics associated with the G0/G1 transition and AURKA activity. Read “High-content phenotyping reveals Golgi dynamics and their role in cell cycle regulation” 👉 https://hubs.la/Q03Tmbgb0

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