Journal of Cell Biology

Journal of Cell Biology The Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press.
The Journal of Cell Biology (JCB) features peer-reviewed research on all aspects of cellular structure and function. Areas include, but are not limited to: • Cell adhesion and motility • Cell cycle and division • Cell growth, survival, and death • Cell structure and dynamics • Cellular communication • Cellular disease mechanisms • Cytoskeleton and molecular motors • Gene expression and RNA metabolism • Methods and techniques • Nuclear organization, function, and structure • Organelle biogenesis and homeostasis • Protein, membrane, and lipid trafficking • Signal transduction • Stem cell biology • Systems and computational cell biology All editorial decisions are made by research-active scientists in conjunction with in-house scientific editors. JCB provides free online access to many article types immediately, with complete archival content freely available online. Established in 1955, JCB is published by The Rockefeller University Press. For more information, visit http://jcb.rupress.org. Follow us on Twitter: https://twitter.com/JCellBiol
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Eisuke Itakura, Momoka Chiba, Takeshi Murata, and Akira Matsuura (https://bit.ly/39LRKvW) identify a protein quality con...
02/21/2020
Heparan sulfate is a clearance receptor for aberrant extracellular proteins | Journal of Cell Biology | Rockefeller University Press

Eisuke Itakura, Momoka Chiba, Takeshi Murata, and Akira Matsuura (https://bit.ly/39LRKvW) identify a protein quality control system for aberrant extracellular proteins, including misfolded proteins and amyloid β. This extracellular proteostasis pathway involves the cell-surface heparan sulfate receptor, which mediates internalization of aberrant extracellular proteins in complex with an extracellular chaperone.

The accumulation of aberrant proteins leads to various neurodegenerative disorders.

Researchers in Japan have identified a new quality control system that allows cells to remove damaged and potentially to...
02/18/2020
Researchers discover how cells clear misfolded proteins from tissues

Researchers in Japan have identified a new quality control system that allows cells to remove damaged and potentially toxic proteins from their surroundings. The study was published today in the Journal of Cell Biology (https://bit.ly/39KPBQY).

Researchers in Japan have identified a new quality control system that allows cells to remove damaged and potentially toxic proteins from their surroundings. The study, which will be published Feb. 18, 2020 in the Journal of Cell Biology, finds that the Clusterin protein and heparan sulfate proteogl...

Synaptic plasticity is the process by which new synapses form between neurons during memory and learning in response to ...
02/18/2020
Syncrip/hnRNP Q is required for activity-induced Msp300/Nesprin-1 expression and new synapse formation | Journal of Cell Biology | Rockefeller University Press

Synaptic plasticity is the process by which new synapses form between neurons during memory and learning in response to repeated use of specific neuronal pathways. Titlow et al have discovered a new factor important for plasticity which regulates how new components are assembled at synapses in response to neuronal activation. https://bit.ly/31OwSS0

In this week's Special Focus, we revisit recent exciting JCB content examining the determinants and mechanisms of cellul...
02/10/2020
Special Focus: Metabolism

In this week's Special Focus, we revisit recent exciting JCB content examining the determinants and mechanisms of cellular metabolism and its interplay with other cellular processes. https://bit.ly/37LoBju

JCB is pleased to present a special collection of articles to coincide with the 2020 Keystone Symposia conference on "In...
02/07/2020
Cellular Mechanisms of Aging

JCB is pleased to present a special collection of articles to coincide with the 2020 Keystone Symposia conference on "Intra- and Intercellular Mechanisms of Aging". https://bit.ly/36ZRdEV

Interested in discussing your latest research with JCB editors and learning how we are making the publishing process easier for authors? Meet Scientific Editor Andrea Marat at this Keystone Symposia conference or contact the Editorial office.

In the second collection celebrating our 65th anniversary, we highlight early studies of the network of tubules and prot...
02/06/2020
JCB65: Cytoskeleton

In the second collection celebrating our 65th anniversary, we highlight early studies of the network of tubules and proteins conferring shape and motility to the cell and its subcompartments. https://bit.ly/2SmoHId

Many key reagents and tools first published in JCB, such as the introduction of latrunculin to study actin dynamics, enabled researchers to explore the functions, ultrastructure, and composition of the cytoskeleton.

Rockefeller University Press joins the call from Wellcome to make published Novel Coronavirus (2019-nCoV) studies rapidl...
02/04/2020

Rockefeller University Press joins the call from Wellcome to make published Novel Coronavirus (2019-nCoV) studies rapidly accessible: https://bit.ly/2SguLSx

Background image credit: Dr_Microbe/iStock by Getty Images

Wiebke Schormann, Santosh Hariharan, and David W. Andrews provide a reference library of confocal micrographs of key org...
01/29/2020
A reference library for assigning protein subcellular localizations by image-based machine learning | The Journal of Cell Biology | Rockefeller University Press

Wiebke Schormann, Santosh Hariharan, and David W. Andrews provide a reference library of confocal micrographs of key organelles in live epithelial cells as landmarks and a derived feature set that can be used to assign protein localization throughout the secretory pathway and to key organelles via a quantitative unbiased image-based classifier. https://bit.ly/2Gg3Ro6

Nucleus centering in mouse oocytes depends on a gradient of actin-positive vesicle persistence. Using modeling coupled t...
01/23/2020
Active diffusion in oocytes nonspecifically centers large objects during prophase I and meiosis I | The Journal of Cell Biology | Rockefeller University Press

Nucleus centering in mouse oocytes depends on a gradient of actin-positive vesicle persistence. Using modeling coupled to 3D-simulations and experimental testing of predictions coming from the simulations, Colin et al. demonstrate that this gradient non-specifically centers large objects during Prophase I and Meiosis I in oocytes. https://bit.ly/2NL5Oxa

01/22/2020
New in RUP Journals!

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Clathrin stabilizes microtubules and promotes chromosome alignment during mitosis. Rondelet et al. show that the clathri...
01/20/2020
Clathrin’s adaptor interaction sites are repurposed to stabilize microtubules during mitosis | The Journal of Cell Biology | Rockefeller University Press

Clathrin stabilizes microtubules and promotes chromosome alignment during mitosis. Rondelet et al. show that the clathrin-adaptor interaction mechanism is repurposed to recruit GTSE1 to the spindle, which inhibits the microtubule depolymerase MCAK and promotes chromosome alignment by stabilizing astral microtubules. https://bit.ly/36T0LCj

Happy New Year! JCB turns 65 in 2020, and in honor of this milestone we have compiled a series of special historical col...
01/15/2020
JCB65: Methods

Happy New Year! JCB turns 65 in 2020, and in honor of this milestone we have compiled a series of special historical collections highlighting some of the groundbreaking work published in the journal. This month, we revisit classic methods that went on to shape cell biological research. https://bit.ly/2Tp18QY

In the first collection celebrating our 65th anniversary , we revisit classic methods that shaped cell biological research.

Pei-Lin Cheng, Min Lee, and colleagues show that local abundance of the chloride importer NKCC1 and timely emergence of ...
01/14/2020
Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain | The Journal of Cell Biology | Rockefeller University Press

Pei-Lin Cheng, Min Lee, and colleagues show that local abundance of the chloride importer NKCC1 and timely emergence of GABAergic inhibition are modulated by proteasome distribution, mediated through interactions of proteasomes with the adaptor Ecm29 and the axon initial segment scaffold protein ankyrin G. https://bit.ly/37KwiGG

Min Lee, Yen-Chen Liu, Chen Chen, Chi-Huan Lu, Shao-Tzu Lu, Tzyy-Nan Huang, Meng-Tsung Hsu, Yi-Ping Hsueh, Pei-Lin Cheng; Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. J Cell Biol 3 February 2020; 219 (2): e201903033. doi: https://doi.org/10.108...

On the cover of JCB—The collagen trail: Journey to the microenvironment. Ovarian cancer cell migrating along a collagen ...
01/09/2020

On the cover of JCB—The collagen trail: Journey to the microenvironment. Ovarian cancer cell migrating along a collagen fiber, imaged using scanning electron microscopy. Image © Elizabeth Harper, University of Notre Dame, Notre Dame, IN.

On the cover of JCB—The collagen trail: Journey to the microenvironment. Ovarian cancer cell migrating along a collagen ...
01/09/2020

On the cover of JCB—The collagen trail: Journey to the microenvironment. Ovarian cancer cell migrating along a collagen fiber, imaged using scanning electron microscopy. Image © Elizabeth Harper, University of Notre Dame, Notre Dame, IN.

We are seeking a talented individual for the role of Scientific Editor or Senior Scientific Editor. A PhD in a field rel...
01/09/2020
Scientific Editor - JCB

We are seeking a talented individual for the role of Scientific Editor or Senior Scientific Editor. A PhD in a field relevant to cell biology is required; postdoctoral experience is preferred. Regular travel to attend relevant scientific meetings and to visit research institutions required. Must have exceptional communication skills and superb attention to detail, as well as a strong interest in scientific publishing and publication ethics. Learn more and apply: https://bit.ly/2FBajG8

The Scientific Editor will oversee the peer review process for submitted manuscripts and recruit high-quality submissions to the Journal of Cell Biology (JCB).

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General information

The Journal of Cell Biology (JCB) features peer-reviewed research on all aspects of cellular structure and function. Areas include, but are not limited to: • Cell adhesion and motility • Cell cycle and division • Cell growth, survival, and death • Cell structure and dynamics • Cellular communication • Cellular disease mechanisms • Cytoskeleton and molecular motors • Gene expression and RNA metabolism • Methods and techniques • Nuclear organization, function, and structure • Organelle biogenesis and homeostasis • Protein, membrane, and lipid trafficking • Signal transduction • Stem cell biology • Systems and computational cell biology All editorial decisions are made by research-active scientists in conjunction with in-house scientific editors. JCB provides free online access to many article types from the date of publication and to all archival content. Established in 1955, JCB is published by The Rockefeller University Press. For more information, visit http://jcb.rupress.org. Follow us on Twitter: https://twitter.com/JCellBiol

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Friday 09:00 - 17:00

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