Journal of Cell Biology

Journal of Cell Biology The Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press.
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The Journal of Cell Biology (JCB) features peer-reviewed research on all aspects of cellular structure and function. Areas include, but are not limited to:

• Cell adhesion and motility
• Cell cycle and division
• Cell growth, survival, and death
• Cell structure and dynamics
• Cellular communication
• Cellular disease mechanisms
• Cytoskeleton and molecular motors
• Gene expression and RNA metab

The Journal of Cell Biology (JCB) features peer-reviewed research on all aspects of cellular structure and function. Areas include, but are not limited to:

• Cell adhesion and motility
• Cell cycle and division
• Cell growth, survival, and death
• Cell structure and dynamics
• Cellular communication
• Cellular disease mechanisms
• Cytoskeleton and molecular motors
• Gene expression and RNA metab

Operating as usual

Sander, Skowronska-Krawczyk, Kiser, Palczewski (University of California, Irvine) and colleagues have parsed the lipid c...
06/17/2021
Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition | Journal of Cell Biology | Rockefeller University Press

Sander, Skowronska-Krawczyk, Kiser, Palczewski (University of California, Irvine) and colleagues have parsed the lipid composition of native-source photoreceptor disks and found large differences in fatty acid unsaturation and chain length between the center and rim regions. They selectively copurified membrane proteins and lipids from each region in styrene maleic acid (SMA) lipid particles (SMALPs) using nanobodies and antibodies.

Sander et al. have parsed the lipid composition of native-source photoreceptor disks and found large differences in fatty acid unsaturation and chain length bet

Vivek K. Gupta, Ovijit Chaudhuri et al. (Stanford University) investigate forces generated during cell division in confi...
06/16/2021
The nature of cell division forces in epithelial monolayers | Journal of Cell Biology | Rockefeller University Press

Vivek K. Gupta, Ovijit Chaudhuri et al. (Stanford University) investigate forces generated during cell division in confining epithelial monolayers. In addition to finding that cells generate forces during mitotic rounding, they find that cells generate protrusive forces along the division axis that drive elongation, and outward forces that facilitate post-division spreading.

Gupta et al. investigate forces generated during cell division in confining epithelial monolayers. In addition to finding that cells generate forces during mito

Silence thy genome! Mezmur D. Belew, W. Matthew Michael et al. (USC Biological Sciences) show that primordial germ cells...
06/16/2021
A global chromatin compaction pathway that represses germline gene expression during starvation | Journal of Cell Biology | Rockefeller University Press

Silence thy genome! Mezmur D. Belew, W. Matthew Michael et al. (USC Biological Sciences) show that primordial germ cells repress gene expression through a novel Global Chromatin Compaction (GCC) mechanism when they undergo starvation. GCC involves interplay between the topoII-condensin axis & heterochromatin.

Belew et al. report that C. elegans primordial germ cells become transcriptionally repressed if embryos hatch without nutrients. They also describe a novel path

Arun A. Chandrakumar, Robert Rottapel (University Health Network) and colleagues reveal that lumen formation in epitheli...
06/15/2021
Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs | Journal of Cell Biology | Rockefeller University Press

Arun A. Chandrakumar, Robert Rottapel (University Health Network) and colleagues reveal that lumen formation in epithelial cells is regulated by ADP-ribosylation and ubiquitylation. The poly-ADP-ribose polymerase Tankyrase inhibits its substrates SH3BP5 and SH3BP5L, which are Rab11a guanine nucleotide exchange factors, while the E3 ligase RNF146 promotes Rab11a activity by degrading Tankyrase during lumenogenesis.

Chandrakumar et al. reveal that lumen formation in epithelial cells is regulated by ADP-ribosylation and ubiquitylation. Tankyrase inhibits its substrates SH3BP

Our "Special Focus" feature highlights our community and showcases the exciting work published in JCB. This week, we rev...
06/14/2021
Special Focus | Journal of Cell Biology | Rockefeller University Press

Our "Special Focus" feature highlights our community and showcases the exciting work published in JCB. This week, we revisit recent JCB content examining how cells respond to mechanical cues. We hope you enjoy this series and welcome your feedback!

Mechanobiology Our recurring, online "Special Focus" feature highlights our community and showcases the exciting work published in JCB.
This week, we revisit recent exciting JCB content examining how cells respond to mechanical cues.
We hope you enjoy t...

Chiara Galloni, Davide Carra, Michael Way (The Francis Crick Institute) and colleagues demonstrate that Arp3B isoform-sp...
06/09/2021
MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes | Journal of Cell Biology | Rockefeller University Press

Chiara Galloni, Davide Carra, Michael Way (The Francis Crick Institute) and colleagues demonstrate that Arp3B isoform-specific Arp2/3 complexes generate branched actin networks with faster disassembly kinetics. This increased turnover is due to oxidation of Met293 of Arp3B by the methionine monooxygenase MICAL2, which is recruited to the branched actin network by coronin 1C.

Galloni, Carra, et al. demonstrate that Arp3B isoform–specific Arp2/3 complexes generate branched actin networks with faster disassembly kinetics. This increase

Although replication stress responses have been extensively studied, almost nothing is known about the replication stres...
06/08/2021
Treacle and TOPBP1 control replication stress response in the nucleolus | Journal of Cell Biology | Rockefeller University Press

Although replication stress responses have been extensively studied, almost nothing is known about the replication stress response in nucleoli. Artem Velichko, Sergey Razin, Omar Kantidze (Russian Academy of Sciences) and colleagues have studied the molecular mechanisms involved in protecting the cell from replication stress induced in rDNA (nucleolus) of higher eukaryotes.

Although replication stress response has been extensively studied, almost nothing is known about the replication stress response in nucleoli. Velichko et al. ha

This month, we explore some of our most exciting recent articles about stem cell and developmental cell biology, in a sp...
06/08/2021
Stem Cells and Development 2021 | Journal of Cell Biology | Rockefeller University Press

This month, we explore some of our most exciting recent articles about stem cell and developmental cell biology, in a special collection that investigates fundamental mechanisms underlying cellular identity, tissue homeostasis and regeneration, and developmental processes using cell models and model organisms.

JCB editors highlight the fields of stem cells and development in this new collection of recent JCB articles. This selection captures exciting advances in our understanding of the molecular and cellular control of stemness and differentiation, reprogram...

The local rules that control cell shape and movement are not understood. Anne Pipathsouk, Orion D. Weiner (UCSF) and col...
06/07/2021
The WAVE complex associates with sites of saddle membrane curvature | Journal of Cell Biology | Rockefeller University Press

The local rules that control cell shape and movement are not understood. Anne Pipathsouk, Orion D. Weiner (UCSF) and colleagues discover a novel nanoscale organization of a key actin regulator that could explain how cellular protrusions expand and self-straighten and how transcellular holes are repaired.

The local rules that control cell shape and movement are not understood. Here, Pipathsouk et al. discover a novel nanoscale organization of a key actin regulato

On the cover of our June Issue: Spinning disk confocal imaging of an aggregate of HEK293 cells expressing EPHB2 and GFP ...
06/07/2021

On the cover of our June Issue:
Spinning disk confocal imaging of an aggregate of HEK293 cells expressing EPHB2 and GFP (green) mixed with HEK293 cells expressing EPHRIN-B1 and LifeAct-mCherry (magenta). This image is taken 72 h after cell mixing and shows cell segregation between cell types, which drives changes in aggregate shape through minimization of heterotypic interfacial tension.
From Kindberg et al (https://bit.ly/2SNProM).
Read JCB June Issue: https://rupress.org/jcb/issue/220/6

On the cover of our June Issue:
Spinning disk confocal imaging of an aggregate of HEK293 cells expressing EPHB2 and GFP (green) mixed with HEK293 cells expressing EPHRIN-B1 and LifeAct-mCherry (magenta). This image is taken 72 h after cell mixing and shows cell segregation between cell types, which drives changes in aggregate shape through minimization of heterotypic interfacial tension.
From Kindberg et al (https://bit.ly/2SNProM).
Read JCB June Issue: https://rupress.org/jcb/issue/220/6

Kaela S. Singleton and Victor Faundez (Emory University School of Medicine) review study by Bowman et al. (https://bit.l...
06/04/2021
Robustness and innovation along the endocytic route: Lessons from darkness | Journal of Cell Biology | Rockefeller University Press

Kaela S. Singleton and Victor Faundez (Emory University School of Medicine) review study by Bowman et al. (https://bit.ly/3viqBvr) that describes an unprecedented mechanism where two sorting complexes, AP-3 and BLOC-1, the latter bound to syntaxin 13, work as a fail-safe to recognize sorting signals in VAMP7, a membrane protein required for fusion to melanosomes.

In this issue, Bowman et al. describe an unprecedented mechanism where two sorting complexes, AP-3 and BLOC-1, the latter bound to syntaxin 13, work as a fail-s

SUMO homeostasis promotes error-free chromosome segregation. Yun Quan, Stephen Hinshaw, Huilin Zhou and colleagues repor...
06/03/2021
Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore | Journal of Cell Biology | Rockefeller University Press

SUMO homeostasis promotes error-free chromosome segregation. Yun Quan, Stephen Hinshaw, Huilin Zhou and colleagues report the structure of a targeting peptide of the Ulp2 desumoylase bound to yeast Ctf3/CENP-I. Disrupting the interaction produces hyper-sumoylated kinetochores, demonstrating the existence of a conserved and dedicated pathway for the regulation of kinetochore sumoylation.

SUMO homeostasis promotes error-free chromosome segregation. Quan et al. report the structure of a targeting peptide of the Ulp2 desumoylase bound to yeast Ctf3

Kinetoplastids are evolutionarily divergent eukaryotes that have an unconventional set of kinetochore proteins. Gabriele...
06/03/2021
Kinetoplastid kinetochore proteins KKT2 and KKT3 have unique centromere localization domains | Journal of Cell Biology | Rockefeller University Press

Kinetoplastids are evolutionarily divergent eukaryotes that have an unconventional set of kinetochore proteins. Gabriele Marcianò, Bungo Akiyoshi et al. (The Department of Biochemistry, University of Oxford) show that KKT2 and KKT3 play important roles in kinetochore assembly in Trypanosoma brucei. Centromere localization of these proteins is mediated by the unique centromere localization domain.

Kinetoplastids are evolutionarily divergent eukaryotes that have an unconventional set of kinetochore proteins. Marcianò et al. show that KKT2 and KKT3 play imp

Xi Yang, Ming Li and colleagues (University of Michigan College of Literature, Science, and the Arts) applied a microflu...
06/01/2021
ESCRT, not intralumenal fragments, sorts ubiquitinated vacuole membrane proteins for degradation | Journal of Cell Biology | Rockefeller University Press

Xi Yang, Ming Li and colleagues (University of Michigan College of Literature, Science, and the Arts) applied a microfluidics-based imaging method to resolve a controversy regarding how ubiquitinated lysosome membrane proteins are sorted into the lumen for degradation. ESCRTs, but not intralumenal fragments, are responsible for the sorting.

Yang et al. applied a microfluidics-based imaging method to resolve a controversy regarding how ubiquitinated lysosome membrane proteins are sorted into the lum

Ioanna Pitsidianaki, Kyra Campbell and colleagues (The University of Sheffield) show that the mesenchymal-to-epithelial ...
06/01/2021
Mesenchymal-to-epithelial transitions require tissue-specific interactions with distinct laminins | Journal of Cell Biology | Rockefeller University Press

Ioanna Pitsidianaki, Kyra Campbell and colleagues (The University of Sheffield) show that the mesenchymal-to-epithelial transition in the Drosophila melanogaster midgut relies both on downregulation of the EMT-transcription factor Serpent, and on the secretion of a specific laminin trimer from the neighbouring mesoderm.

Pitsidianaki et al. show that the mesenchymal-to-epithelial transition in the Drosophila melanogaster midgut relies both on downregulation of the EMT-transcript

Ruth A. Houseright, Veronika Miskolci, Anna Huttenlocher and colleagues (University of Wisconsin-Madison) show that myel...
05/31/2021
Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage | Journal of Cell Biology | Rockefeller University Press

Ruth A. Houseright, Veronika Miskolci, Anna Huttenlocher and colleagues (University of Wisconsin-Madison) show that myeloid-derived growth factor (MYDGF) regulates neutrophil behavior in response to tissue damage but not microbial cues. The findings suggest that MYDGF promotes wound healing in larval zebrafish by providing a brake on neutrophil inflammation.

This study shows that MYDGF regulates neutrophil behavior in response to tissue damage but not microbial cues. The findings suggest that MYDGF promotes wound he

In this study, Ewelina Trela, Marja Mikkola et al. (University of Helsinki) delineate the cellular mechanisms governing ...
05/31/2021
Cell influx and contractile actomyosin force drive mammary bud growth and invagination | Journal of Cell Biology | Rockefeller University Press

In this study, Ewelina Trela, Marja Mikkola et al. (University of Helsinki) delineate the cellular mechanisms governing early mammary gland development and find that its initial growth is primarily accomplished by cell migration. Moreover, they suggest that mammary bud invagination is driven by contractile cells encircling the bud—the ring cells.

In this study, Trela et al. delineate the cellular mechanisms governing early mammary gland development and find that its initial growth is primarily accomplish

Corinne Tovey, Paul Conduit (University of Cambridge) and colleagues show that auto-inhibition regulates the binding bet...
05/28/2021
Autoinhibition of Cnn binding to γ-TuRCs prevents ectopic microtubule nucleation and cell division defects | Journal of Cell Biology | Rockefeller University Press

Corinne Tovey, Paul Conduit (University of Cambridge) and colleagues show that auto-inhibition regulates the binding between microtubule nucleating complexes and proteins that tether them to sites of microtubule nucleation. Failure to properly regulate this binding can lead to ectopic cytosolic microtubule nucleation and major defects during cell division.

We show that autoinhibition regulates the binding between microtubule nucleating complexes and proteins that tether them to sites of microtubule nucleation. Fai

Yilin Fan, Tobias Meyer (Weill Cornell Medicine) and colleagues show that replisome disassembly during S phase is requir...
05/28/2021
LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome components | Journal of Cell Biology | Rockefeller University Press

Yilin Fan, Tobias Meyer (Weill Cornell Medicine) and colleagues show that replisome disassembly during S phase is required for efficient DNA replication by recycling essential replisome components between chromatin-bound and soluble compartments.

Fan et al. show that replisome disassembly during S phase is required for efficient DNA replication by recycling essential replisome components between chromati

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General information

The Journal of Cell Biology (JCB) features peer-reviewed research on all aspects of cellular structure and function. Areas include, but are not limited to: • Cell adhesion and motility • Cell cycle and division • Cell growth, survival, and death • Cell structure and dynamics • Cellular communication • Cellular disease mechanisms • Cytoskeleton and molecular motors • Gene expression and RNA metabolism • Methods and techniques • Nuclear organization, function, and structure • Organelle biogenesis and homeostasis • Protein, membrane, and lipid trafficking • Signal transduction • Stem cell biology • Systems and computational cell biology All editorial decisions are made by research-active scientists in conjunction with in-house scientific editors. JCB provides free online access to many article types from the date of publication and to all archival content. Established in 1955, JCB is published by The Rockefeller University Press. For more information, visit http://jcb.rupress.org. Follow us on Twitter: https://twitter.com/JCellBiol

Opening Hours

Monday 09:00 - 17:00
Tuesday 09:00 - 17:00
Wednesday 09:00 - 17:00
Thursday 09:00 - 17:00
Friday 09:00 - 17:00

Telephone

(212) 327-7938

Products

- biobytes, the monthly podcast: http://jcb.rupress.org/biobytes/

- biosights, the video series: http://jcb.rupress.org/biosights/

- biowrites, the JCB blog: http://jcb.rupress.org/biowrites/

- the JCB DataViewer, a browser-based application for viewing original image data: http://jcb-dataviewer.rupress.org/

- the JCB App for iPhone and iPad: https://itunes.apple.com/us/app/the-journal-of-cell-biology/id481769378

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