Journal of Cell Biology

Journal of Cell Biology The Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press.

A recent model suggests the risk factor protein TMEM175 is primarily a proton-conducting channel. Erika Riederer, Deji...
10/24/2025

A recent model suggests the risk factor protein TMEM175 is primarily a proton-conducting channel. Erika Riederer, Dejian Ren and colleagues (University of Pennsylvania) demonstrate that TMEM175 does not mediate a lysosomal proton leak & is not responsible for preventing lysosomal over-acidification https://hubs.la/Q03Q2_K10

Ana Dias Maia Henriques, Julien Dumont, Gilliane Maton and colleagues (Université Paris Cité) uncover an A pathway, dr...
10/22/2025

Ana Dias Maia Henriques, Julien Dumont, Gilliane Maton and colleagues (Université Paris Cité) uncover an A pathway, driven by the -13 KLP-7 and opposed by the kinesin-12 KLP-18, that contributes to chromosome segregation in early embryos. https://hubs.la/Q03PNJs30

Ivan Avilov, Peter Lenart and colleagues (Max Planck Society) used quantitative phosphoproteomics in to identify dow...
10/22/2025

Ivan Avilov, Peter Lenart and colleagues (Max Planck Society) used quantitative phosphoproteomics in to identify downstream targets of the conserved Mos–MAPK pathway. https://hubs.la/Q03PKvsY0

New work from Guanhua Bai, Hao Li, Mingjie Zhang and colleagues (Southern University of Science and Technology - SUSTech...
10/22/2025

New work from Guanhua Bai, Hao Li, Mingjie Zhang and colleagues (Southern University of Science and Technology - SUSTech) reveals an unexpected function of IQSEC2 as a scaffold protein and thus explains why IQSEC2 can bidirectionally regulate synaptic strengths. https://hubs.la/Q03PKtsD0

László Fazekas, Diána Kaszás, Boldizsár Vámosi, Balázs Enyedi and colleagues (Semmelweis University) describe a -specif...
10/22/2025

László Fazekas, Diána Kaszás, Boldizsár Vámosi, Balázs Enyedi and colleagues (Semmelweis University) describe a -specific synthetic promoter that enables expression & targeted ablation in fins & reveal a role for fibroblasts in osmotic surveillance by wound-induced calcium patterns https://hubs.la/Q03PKtJr0

Wyatt Miller, Meghan Morrissey et al. (UC Santa Barbara) demonstrate that the CD47 signaling pathway prevents thru.dep...
10/16/2025

Wyatt Miller, Meghan Morrissey et al. (UC Santa Barbara) demonstrate that the CD47 signaling pathway prevents thru.dephosphorylation of the Rac GEF Vav. Cancer cells & synthetic targets with CD47 can still be phagocytosed less efficiently through a Rho-dependent mechanism. https://hubs.la/Q03NZY3Q0

Corbin Jensen, Mark Peifer et al. (UNC Lineberger Comprehensive Cancer Center) reveal that the intrinsically disordered ...
10/16/2025

Corbin Jensen, Mark Peifer et al. (UNC Lineberger Comprehensive Cancer Center) reveal that the intrinsically disordered region of Canoe is critical for its role in linking cell–cell adherens junctions to the . https://hubs.la/Q03N-djb0

Perspective from Richard McIntosh (University of Colorado Boulder) describing the history of research on polymerizatio...
10/15/2025

Perspective from Richard McIntosh (University of Colorado Boulder) describing the history of research on polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. https://hubs.la/Q03NJTQ40

Chris Ho, Stephanie Gupton et al. (UNC Lineberger Comprehensive Cancer Center) find that coronin 1A mediates neuronal gr...
10/14/2025

Chris Ho, Stephanie Gupton et al. (UNC Lineberger Comprehensive Cancer Center) find that coronin 1A mediates neuronal growth cone & filopodial dynamics, & its interaction with E3 ubiquitin ligase TRIM67 is required for morphological responses to the guidance cue netrin-1 https://hubs.la/Q03NvpQc0

The deadline is approaching to apply for JCB’s Alan Hall & Norton B. Gilula Travel Awards. The awards support attendance...
10/14/2025

The deadline is approaching to apply for JCB’s Alan Hall & Norton B. Gilula Travel Awards. The awards support attendance for undergraduates, grad students, and early-career postdocs at CellBio 2025 (Dec. 6-10) in Philadelphia! Apply by Oct. 17 👉 https://hubs.la/Q03NmTgX0

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