Journal of Cell Biology

Journal of Cell Biology The Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press.

07/14/2025

Biljana Ermanoska, Jonathan Baets, and Avital Rodal (Brandeis University) show that a presynaptic actomyosin core coordinates with Integrin receptors to maintain neuron-muscle mechanical continuity at neuromuscular junctions. https://hubs.la/Q03x3JfP0

Vanessa Teixeira, Reto Gassmann and colleagues (Instituto de Investigação e Inovação em Saúde) identify the onconeural a...
07/10/2025

Vanessa Teixeira, Reto Gassmann and colleagues (Instituto de Investigação e Inovação em Saúde) identify the onconeural antigen CDR2 as an ER-localized adaptor for the microtubule-based motor cytoplasmic dynein-1 and show that CDR2 contributes to ER organization through its interaction with the integral ER membrane protein kinectin. https://hubs.la/Q03wGPkB0

Astrid Petzoldt and colleagues (Freie Universität Berlin) identify the conserved unconventional class XV myosin, Myo15, ...
07/08/2025

Astrid Petzoldt and colleagues (Freie Universität Berlin) identify the conserved unconventional class XV myosin, Myo15, an actin motor, as a novel regulator of presynaptic assembly and remodeling in . They find Myo15 to be essential for presynaptic functional homeostatic plasticity and memory consolidation. https://hubs.la/Q03wg22w0

Milena Pasolli, Joyce Meiring, Anna Akhmanova and colleagues (Utrecht University) describe tools to acutely relocate i...
07/08/2025

Milena Pasolli, Joyce Meiring, Anna Akhmanova and colleagues (Utrecht University) describe tools to acutely relocate intermediate filaments by inducibly coupling them to microtubule motors. Rapid perinuclear clustering of vimentin had no strong effects on microtubules or actin but was accompanied by redistribution of mitochondria and endoplasmic reticulum sheets, and reduced cell stiffness. https://hubs.la/Q03wf-9G0

Our July cover (https://hubs.la/Q03vJ8z30) sshows a confocal timelapse imaging of one-cell embryo expressing fluoresce...
07/07/2025

Our July cover (https://hubs.la/Q03vJ8z30) sshows a confocal timelapse imaging of one-cell embryo expressing fluorescently labeled plasma membrane, microtubules, chromosomes, and ZEN-4, a plus-end directed kinesin motor protein and a component of the centralspindlin complex. The plasma membrane and microtubules are shown in mpl-magma, chromosomes are shown in gray, and ZEN-4 accumulation on the spindle midzone is shown in red. With the progression of cytokinetic furrow ingression, the accumulation of ZEN-4 at the spindle midzone ensures cytokinesis completion. By Adhikary et al. https://hubs.la/Q03vJ8kc0

Lipid synthesis supports membrane growth and organelle biogenesis. Sunyoung Hwang, Eduardo Torres et al. (UMass Chan Med...
07/03/2025

Lipid synthesis supports membrane growth and organelle biogenesis. Sunyoung Hwang, Eduardo Torres et al. (UMass Chan Medical School) show that synthesis of sphingolipids, mainly long-chain bases, is essential to increasing nuclear membranes during . Failure to make sphingolipids in human cells causes abnormal nuclear morphology and genomic instability. https://hubs.la/Q03vNmR00

Spindle morphology changes rapidly and dramatically at the meiosis to mitosis transition in early embryogenesis. Helena ...
07/01/2025

Spindle morphology changes rapidly and dramatically at the meiosis to mitosis transition in early embryogenesis. Helena Cantwell, Rebecca Heald and colleagues (UC Berkeley) uncover differential CK2 regulation of the RanGTP pathway of spindle assembly in meiosis and mitosis driving this change. https://hubs.la/Q03vrGNt0

🧑‍🔬🎙️ When you publish with JCB, you can reach more of your community by submitting a short video! Want to promote your ...
07/01/2025

🧑‍🔬🎙️ When you publish with JCB, you can reach more of your community by submitting a short video! Want to promote your research in your own voice? 🎦 See our guidelines: https://hubs.la/Q03vqZNm0
▶️ Watch video summaries from our authors: https://hubs.la/Q03vr1gF0

Gemma Stathatos, Jessica Dunleavy, Moira O'Bryan, and colleagues (The University of Melbourne) reveal essential roles fo...
06/30/2025

Gemma Stathatos, Jessica Dunleavy, Moira O'Bryan, and colleagues (The University of Melbourne) reveal essential roles for TUBD1 in male germ cell development and male fertility, specifically in stabilizing the meiotic kinetochores during division and shaping the s***m head via the manchette. Their data suggest that TUBD1 interacts with katanins to achieve microtubule severing. https://hubs.la/Q03vcY4B0

The E3 ligase Parkin ubiquitinates many proteins. Joanna Koszela, Helen Walden and colleagues (University of Glasgow) id...
06/27/2025

The E3 ligase Parkin ubiquitinates many proteins. Joanna Koszela, Helen Walden and colleagues (University of Glasgow) identify and biochemically validate a direct Parkin interaction with a substrate, Miro1. The results explain fast kinetics of Miro1 ubiquitination by Parkin in recombinant assays and provide a molecular basis for previous observations of Miro1-dependent Parkin recruitment to mitochondrial membrane. https://hubs.la/Q03v39h20

Michael Stewart, Matthew Miller and colleagues (The University of Utah) show that Stu2 displays dynamic localization pat...
06/27/2025

Michael Stewart, Matthew Miller and colleagues (The University of Utah) show that Stu2 displays dynamic localization patterns in the , with different kinetochore and microtubule distributions during distinct phases. Phosphorylation near Stu2’s C-terminus reduces its attachment to kinetochores to promote its microtubule activity in anaphase. Cdc5 and PP2ACdc55 play counteracting roles in this pathway to promote proper timing of Stu2 phosphorylation. https://hubs.la/Q03v39bP0

06/27/2025

Juhi Narula and Sarah Wignall (Northwestern University) identify a new role for the conserved kinase PLK-1 in suppressing centrosome maturation in oocytes, which surprisingly is opposite to its role in mitosis. https://hubs.la/Q03v35Qg0

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