
10/17/2025
In May 2005, Isabelle Dinoire, a 38-year-old French woman, overdosed on sleeping pills and fell unconscious at home, after which her dog mauled her face, causing severe injuries to her nose, lips, and chin that left her unable to eat solid food, speak clearly, or express facial emotions. Traditional reconstructive surgery proved inadequate to repair the extensive damage. In November 2005, at Amiens University Hospital, she became the first person to receive a partial face transplant, with surgeons grafting skin, muscles, and blood vessels from a brain-dead female donor to restore basic functions. The procedure allowed her to regain the ability to speak, eat normally, and smile, though she required lifelong immunosuppressive drugs to prevent rejection and had to adapt to a face blending her original features with the donor's. Despite complications like infections and the psychological challenges of the transplant, it marked a medical milestone, giving Dinoire a functional face and improved quality of life until her death in 2016 from transplant-related issues.