The American Journal of Pathology

06/04/2025

: Role of Platelet Activating Factor as a Mediator of Inflammatory Diseases and Preterm Delivery. Authors from Kulliyyah of Medicine, IIUM and Universiti Putra Malaysia.



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06/04/2025

Consider submission to The American Journal of Pathology for your upcoming manuscript focusing on mechanistic discoveries in the progression of human disease. Submission is free!

https://www.editorialmanager.com/ajpa/default2.aspx

06/04/2025

: Mitochondrial protease AFG3L2 inhibits ferroptosis of intestinal epithelial cells through PPARA/GPX4 signaling pathway to improve experimental enteritis.

Full text:

The pathogenesis of Crohn's disease (CD) remains unclear, with mitochondrial dysfunction and ferroptosis emerging as important contributors. However, the specific mechanisms linking mitochondria, ferroptosis, and CD are not well understood. Through bioinformatics analysis using the Gene Expression O...

06/03/2025

: Exploratory study of prognostic plasma biomarkers in patients with pulmonary arterial hypertension. Authors from Institut universitaire de cardiologie et de pneumologie de Québec-UL, Fukushima Medical University ( 福島県立医科大学), and Université Laval.

text:

Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary vascular lumen occlusion, ultimately leading to right ventricular failure and death. Risk stratification is essential for the management of patients with PAH. So far, B-type natriuretic peptide and its N-terminal pro–f...

06/03/2025

C5aR1 Promotes Invasion, Metastasis and Poor Prognosis in Cutaneous Squamous Cell Carcinoma. Authors from Turun yliopisto - University of Turku, Tyks Turun yliopistollinen keskussairaala and the University of Helsinki.

text:

Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and the metastatic from is associated with a poor prognosis. Here, the role of the complement C5a receptor C5aR1 was examined in the progression and metastasis of cSCC. C5aR1 expression was increased in cSCC cells in...

06/02/2025

New month, new ! The June 2024 issue of The American Journal of Pathology is now fully free in the .

Full issue: https://ajp.amjpathol.org/issue/S0002-9440(23)X0007-8

On the cover: Cartilage repair following P15-1 and high-molecular-weight hyaluronan injections.

05/30/2025

Be sure to follow The American Journal of Pathology on all our social media platforms!

05/30/2025

Read the latest Editorial from longtime American Society for Investigative Pathology member and The American Journal of Pathology Editorial Board member Avrum Gotlieb at the University of Toronto.

The American Journal of Pathology’s Contribution to Advancing the Understanding of the Pathogenesis of

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00070-7/fulltext

05/29/2025

Read the latest from The American Journal of Pathology and Elsevier: Study Links a Novel Biomarker with Potential to Predict and Treat Skin Cancer Metastasis.

Full release: https://rb.gy/zh9xjl

05/29/2025

: IL-6 Up-Regulates Expression of LIM-Domain Only Protein 4 in Psoriatic Keratinocytes through Activation of the MEK/ERK/NF-κB Pathway. Authors from Anhui Medical University and WanNan Medical College.

Full text: https://loom.ly/Pq-I4mI

05/29/2025

The June issue of The American Journal of Pathology is now live!

Full issue: https://ajp.amjpathol.org/issue/S0002-9440(24)X0007-3

On the cover: The expression of C5aR1 in cSCC metastases.