The American Journal of Pathology

07/21/2025

: Current Therapeutic targets for Alcohol-associated liver disease. Authors from
Anhui Medical University.

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ALD is a liver disorder induced by chronic excessive alcohol consumption, affecting approximately 3.5% of the global population. The spectrum of ALD encompasses simple steatosis, alcoholic hepatitis, fibrosis, cirrhosis, and the potential development of hepatocellular carcinoma. The pathogenesis of....

07/21/2025

Laminin-γ2-NR6A1 fusion protein promotes metastatic potential in non-small lung carcinoma cells without EGFR mutation. Authors from Science Tokyo（Institute of Science Tokyo）

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Laminin-γ2 fusion gene (Lm-γ2F), formed by translocation between LAMC2 and NR6A1, functions as an epidermal growth factor receptor (EGFR) ligand. However, its expression and impact on cancers beyond the initially studied contexts remain unclear. This study focused on Lm-γ2F protein secretion and ...

07/18/2025

: From Single-Cancer to Pan-cancer Prognosis: A Multi-modal Framework for Survival Analysis with Robust Generalization Capability. Authors from Peking University.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00238-X/fulltext

07/18/2025

Transcription Factor YY2 inhibits tumor cell glutamine catabolism by regulating GLS1 RNA splicing isoform GAC. Authors from 筑波大学｜University of Tsukuba

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The metabolic reprogramming of amino acids is critical for tumorigenesis. Alterations in amino acid metabolism are frequently observed in tumors and are crucial for fulfilling the demand for macromolecular biosynthesis, redox balance, and energy production in tumor cells. Despite its importance, the...

07/17/2025

: Prostacyclin assists in the repair of ruptured amnions through the proliferation and migration of amnion mesenchymal cells.

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Preterm prelabor rupture of membrane (pPROM) is a risk factor for preterm birth. However, spontaneous healing of ruptured fetal membranes is occasionally clinically observed. Prostaglandins are involved in the wound-healing process in various tissues. Here, the roles of prostacyclin (PGI2) in the re...

07/17/2025

: TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease. Authors from Yale University, Yale School of Medicine and Michigan Medicine (University of Michigan).

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Interactions between endothelial cells (ECs) and mural pericytes (PCs) are critical in maintaining the stability and function of the microvascular wall. Abnormal interactions between these two cell types are a hallmark of progressive fibrotic diseases such as systemic sclerosis (also known as sclero...

07/16/2025

ADAM10 regulates EfnB2-mediated Endothelial Cell Sprouting and Ischemic Retinopathy. From American Society for Investigative Pathology member author Dr. Nikhlesh Singh and colleagues from Wayne State University, Wayne State University School of Medicine, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, and University of Wisconsin School of Medicine and Public Health.

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Retinal neovascularization is the leading cause of visual impairment in diabetic retinopathy, retinopathy of prematurity, and age-related macular degeneration. The extracellular matrix breakdown by metalloproteinase leads to vascular complications in various proliferative retinopathies. A disintegri...

07/16/2025

Read the latest from The American Journal of Pathology and Elsevier: Groundbreaking Study Offers a Novel Approach to Enhance Neuromuscular Function in Patients with Duchenne Muscular Dystrophy

Full release: https://loom.ly/VExdGV0

07/16/2025

: The substructure of the endothelial glycocalyx in rat aorta and its interaction with the low-density lipoproteins (LDL).

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00237-8/fulltext

07/15/2025

: Enhanced Optic Nerve Expansion and Altered Ultrastructure of Elastic Fibers Induced by Lysyl Oxidase Inhibition in a Mouse Model of . From American Society for Investigative Pathology member Dr. Rachel Kuchtey and colleagues at Vanderbilt Health and

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Two major constituents of exfoliation material, fibrillin-1 and lysyl oxidase-like 1 (encoded by FBN1 and LOXL1), are implicated in exfoliation glaucoma, yet their individual contributions to ocular phenotype are minor. To test the hypothesis that a combination of FBN1 mutation and LOXL1 deficiency....

07/15/2025

: Endothelial cell STING regulates IL6 production and is required for pathological cardiac hypertrophy and contractile dysfunction in experimental heart failure. From American Society for Investigative Pathology member author Dr. Pilar Alcaide and colleagues from Tufts University School of Medicine, Tufts Graduate School of Biomedical Sciences and the Albany Med Health System.

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Capillary rarefaction and cardiomyocyte (CM) hypertrophy are hallmarks of the complex syndrome of heart failure (HF), a leading cause of hospitalization and death. Molecular signals within and between cellular components of the heart have emerged as central hubs that modulate cardiac pathophysiology...

07/14/2025

: Characterizing Kupffer Cell Production of CD5L and Its Function on Regulating Migration of Natural Killer T Cells. From American Society for Investigative Pathology member Dr. Bangyan Styles and colleagues from USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, Keck School of Medicine of USC, USC Viterbi School of Engineering, and the VA Greater Los Angeles Healthcare System.

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CD5L (CD5 antigen-like) is a multifunctional glycoprotein characterized for its role in the lipid metabolism, particularly within macrophages. In the liver, CD5L strongly correlates with liver injury. We explored the role of CD5L on liver lipid accumulation and inflammatory response. We show that CD...