The American Journal of Pathology

09/24/2026

: Perilipin 2 Mediates Progression of Lung Adenocarcinoma by Modulating Lipid Metabolism. Authors from 帝京大学｜Teikyo University

text:

Perilipin 2 expression is related to poor prognosis of patients with various malignant tumors. It exists on the surface of lipid droplets (LDs), which store lipids that can be used as an energy source during cancer progression. However, the underlying mechanism of lipid metabolism involving LDs in t...

09/22/2026

: HIF-1α-induced astrocytic D-dopachrome tautomerase activates microglial inflammatory response following spinal cord injury.

text:

Spinal cord injury (SCI) often results in severe hypoxia and excessive activation of neuroinflammation, which aggravates neuropathology and neurologic dysfunction. D-dopachrome tautomerase (D-DT), the homolog of macrophage migration inhibitory factor, is a key proinflammatory mediator implicated in....

09/21/2026

- Organ to Organ Crosstalk in Disease

Submission is free: https://www.editorialmanager.com/ajpa/Default.aspx

Deadline: November 30, 2026

Send your work for consideration today!

09/17/2026

: Macrophage–Kruppel-Like Factor 6 Signaling Promotes Experimental Atherogenesis. From American Society for Investigative Pathobiology member author Ganapati Mahabeleshwar and colleagues from Case Western Reserve University School of Medicine

text:

A hallmark event in the development of atherosclerotic plaque is the accumulation of lipid-laden macrophages in the subendothelial layers of affected blood vessels. Macrophages are key players in all stages of atherogenesis, including plaque initiation, growth, and rupture, as well as healing of rup...

09/15/2026

: Metabolic dysfunction-associated steatotic liver disease in patients and mouse with Wilson’s disease.

text: https://ajp.amjpathol.org/article/S0002-9440(25)00191-9/fulltext

09/11/2026

: Super-resolution microscopy reveals alterations in clathrin structure in human cancer tissue. Authors from UCL, IPO-Porto, Universidade do Porto, and the The University of Edinburgh.

text: https://ajp.amjpathol.org/article/S0002-9440(25)00190-7/fulltext

09/10/2026

: Single-Cell Sequencing Has Revealed the Palmitoylation Landscape in Lung Adenocarcinoma and Identified ABHD17C as a Novel Biomarker

Free in the :

Protein S-palmitoylation, a reversible posttranslational modification, is crucial for tumor progression. However, the palmitoylation landscape in tumor cells and its variability within different tumor cell populations remain underexplored. This study was designed to analyze protein palmitoylation us...

09/09/2026

: Early endosome disturbance and endolysosomal pathway dysfunction in .

Authors from the Sorbonne Université, Université Paris-Est Créteil (UPEC), Nantes Université and Hôpital Pitié Salpêtrière, AP-HP

Free in the : https://ajp.amjpathol.org/article/S0002-9440(25)00189-0/fulltext

09/07/2026

Macrophage Polarization and Spatial Architecture Characterize the Tumor Immune Microenvironment and Prognosis in Hepatoblastoma. Authors from University of Helsinki, HUS Helsingin yliopistollinen sairaala, Turun yliopisto - University of Turku, St. Louis Children's Hospital and Tampere University

text: https://ajp.amjpathol.org/article/S0002-9440(26)00164-1/fulltext

09/07/2026

: Activin A Prevents Hyperresponsiveness to Vascular Endothelial Growth Factor in Pathologic Blood Vessels by Perturbing the Trafficking of Activated Vascular Endothelial Growth Factor Receptor 2.

From American Society for Investigative Pathobiology member author Dr. Andrius Kazlauskas and colleagues from University of Illinois Chicago

text:

Although quality-of-life compromising afflictions, such as diabetic retinopathy (DR), are driven by vascular endothelial growth factor (VEGF), there is a growing appreciation that the concentration of VEGF is not the only influencer of vascular dysfunction within the retina. Herein, activin A (activ...