The American Journal of Pathology

10/26/2025

: The Role of Twist1 in Chronic Pancreatitis–Associated Pancreatic Stellate Cells. Authors from Augusta University and Cedars-Sinai.

text: https://ajp.amjpathol.org/article/S0002-9440(24)00234-7/fulltext

10/25/2025

: Lactate Contributes to Remote Ischemic Preconditioning–Mediated Protection Against Myocardial Ischemia Reperfusion Injury by Facilitating Autophagy via the AMP-Activated Protein Kinase–Mammalian Target of Rapamycin–Transcription Factor EB–Connexin 43 Axis.

Free in the : https://ajp.amjpathol.org/article/S0002-9440(24)00247-5/fulltext

10/24/2025

: Hepatocyte-Specific MET Deletion Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice. From American Society for Investigative Pathology member Bharat Bhushan and colleagues from University of Pittsburgh and Pittsburgh Liver Research Center.

text: https://ajp.amjpathol.org/article/S0002-9440(25)00367-0/fulltext

10/24/2025

Emerging Insights into Protein Post-Translational Modifications in Chlamydia-Host Interactions

Full text:

Chlamydia species are responsible for significant diseases in both humans and animals, with their infection processes involving complex interactions with host cells. Protein post-translational modifications (PTMs) have emerged as a critical focus in understanding the complex interplay between Chlamy...

10/24/2025

: Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice.

text: https://ajp.amjpathol.org/article/S0002-9440(24)00237-2/fulltext

10/23/2025

: Targeting RORγ to Boost Regulatory T cells and Ameliorate Diabetic Retinopathy in Mice. From American Society for Investigative Pathology member Devy Deliyanti and colleagues from The University of Melbourne.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00363-3/abstract

10/23/2025

: Cardiac Atrophy, Dysfunction, and Metabolic Impairments: A Cancer-Induced Cardiomyopathy Phenotype. Authors from University of Guelph, York University, VCU School of Medicine on the MCV Campus and Dalhousie University.

text: https://ajp.amjpathol.org/article/S0002-9440(24)00241-4/fulltext

10/22/2025

NSUN5 Mediates Resistance to Doxorubicin via Upregulation of DNA Damage Repair Proteins BRCA2 and BRIP1 in Colorectal Cancer. From new American Society for Investigative Pathology member Dr. Wen Ni and colleagues from Sun Yat-sen University - SYSU 中山大学 and Nanchang University.

text:

Despite advancements in diagnosis and therapy, chemotherapy resistance and metastasis remain significant challenges for colorectal cancer (CRC) patients. Addressing resistance to cell death is crucial for improving cancer treatment outcomes. NOP2/Sun RNA methyltransferase 5 (NSUN5) has been implicat...

10/20/2025

Hyperactivation of TAK1 causes skeletal muscle pathology reminiscent of inflammatory myopathies. From American Society for Investigative Pathology member author Dr. Ashok Kumar and colleagues from the University of Houston College of Pharmacy.

text:

Loss of skeletal muscle mass and strength is a debilitating consequence of various chronic diseases, inflammatory myopathies, and neuromuscular disorders. Inflammation plays a major role in the perpetuation of myopathy in degenerative muscle diseases. Transforming growth factor-β–activated kinase...

10/17/2025

Send in your original research related to spatial pathobiology in mechanisms of disease for an upcoming theme issue.

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10/17/2025

Enhancement of TNFα-mediated hepatic apoptosis and liver injury by Hepatitis B virus surface antigen.

Full text:

Tumor necrosis factor-α (TNF-α) is a highly pleiotropic cytokine with a variety of biological functions, such as cell proliferation, metabolic activation, inflammatory response, and cell death. TNF-α can induce a variety of mechanisms to initiate hepatocyte apoptosis, resulting in subsequent live...

10/15/2025

Peroxisome Proliferator-activated Receptor Agonist IVA337 Alleviates Inflammation and Fibrosis in MASH by Restoring Lipid Homeostasis. Authors from Sanford Burnham Prebys and UC San Diego.

text:

Metabolic dysfunction–associated steatohepatitis (MASH), an advanced stage of metabolic dysfunction–associated steatotic liver disease, is characterized by significant hepatic fibrosis and inflammation. The pan-peroxisome proliferator–activated receptor (pan-PPAR) agonist IVA337 (lanifibranor)...