Contemporary Pediatrics

Contemporary Pediatrics Expert Clinical Advice for Today's Pediatrician

👃 Could sound help relieve chronic nasal congestion?In a feasibility study of adolescents with chronic rhinitis, acousti...
06/16/2026

👃 Could sound help relieve chronic nasal congestion?

In a feasibility study of adolescents with chronic rhinitis, acoustic resonance therapy reduced nasal congestion by 35.2% and improved overall symptoms by 40.5%, with no adverse events reported.

Read our Q&A with SoundHealth CEO Paramesh Gopi, PhD: https://hubs.ly/Q04lD9zc0

A potential new avenue of research is emerging for monoamine oxidase deficiency (MAOD), a rare neurodevelopmental disord...
06/16/2026

A potential new avenue of research is emerging for monoamine oxidase deficiency (MAOD), a rare neurodevelopmental disorder with limited treatment options.

The FDA has granted Orphan Drug Designation to para-chloro-phenylalanine (pCPA), a serotonin synthesis inhibitor being explored as a potential therapy for MAOA deficiency and combined MAO-A/B deficiency.

Key points for pediatricians:
• MAOD affects serotonin, dopamine, and norepinephrine metabolism
• Patients may experience developmental delay, intellectual disability, autism, and growth impairment
• The designation provides incentives for future drug development but does not establish efficacy or safety
• No MAOD clinical trial results have yet been reported

The announcement represents an early step in therapeutic development for an ultrarare disorder with significant unmet need.

Read the full story: https://hubs.li/Q04lBMjM0

🌅 Children and adolescents with Prader-Willi syndrome (PWS) may have a potential new treatment option on the horizon.At ...
06/16/2026

🌅 Children and adolescents with Prader-Willi syndrome (PWS) may have a potential new treatment option on the horizon.

At , investigators reported 6-month interim phase 2 data showing that setmelanotide (Rhythm Pharmaceuticals) was associated with reductions in BMI, fat mass, hyperphagia scores, and anxiety-related behaviors in patients aged 6 to 23 years with PWS.

🔑Key findings:
• Mean BMI reduction of 3.06%
• Mean fat mass reduction of 4.19%
• 8 of 10 patients with moderate-to-severe hyperphagia achieved clinically meaningful improvement
• Improvements also observed in anxiety and distress-related behaviors

The study remains ongoing, and larger phase 3 trials will be needed to confirm efficacy and safety.

🔗Read the full coverage: https://hubs.li/Q04lBPZ60

⚠️ FDA Warning Letter Alert: SNOO Smart SleeperThe FDA issued a Warning Letter today to Happiest Baby, Inc., maker of th...
06/15/2026

⚠️ FDA Warning Letter Alert: SNOO Smart Sleeper

The FDA issued a Warning Letter today to Happiest Baby, Inc., maker of the SNOO Smart Sleeper bassinet — citing multiple violations with direct implications for clinical practice.

Key issues clinicians should know:

🔹 The X-Small and X-Large sleep sacks were distributed without FDA review. The XS may compress vital organs in infants 5–8 lbs; the XL may ride up and cover the airway.

🔹 The SNOO Hospital Bundle was marketed to NICUs and clinical settings without premarket authorization. The original De Novo clearance (DEN210039) was for home use only.

🔹 Refurbished units distributed to customers had documented stains, soiling from bodily fluids, and unsanitary conditions — 100% of a sampled batch failed the company's own quality standards.

🔹 Mold was reported on SNOO mattresses and/or mattress covers.

The FDA is urging clinicians and caregivers to stop using the unauthorized sleep sack sizes and hospital bundle until FDA review is completed.

📋 Report issues via FDA MedWatch.
📄 Full article: https://hubs.li/Q04ltRPp0

⚠️ RECALL ALERT ⚠️Nara Organics Whole Milk Organic Powdered Infant Formula has been recalled following a multistate outb...
06/15/2026

⚠️ RECALL ALERT ⚠️

Nara Organics Whole Milk Organic Powdered Infant Formula has been recalled following a multistate outbreak of infant botulism affecting babies in California, Pennsylvania, and Washington. All 3 infants were hospitalized. No deaths have been reported.

The formula was sold at Target stores, https://hubs.li/Q04lryq90, and https://hubs.li/Q04lrGRp0 between July 2025 and June 2026.

https://hubs.li/Q04lryNw0

🚨The FDA has approved teplizumab (Tzield) to delay the loss of endogenous insulin production in children and adolescents...
06/15/2026

🚨The FDA has approved teplizumab (Tzield) to delay the loss of endogenous insulin production in children and adolescents aged 8 to 17 years recently diagnosed with Stage 3 type 1 diabetes.

The approval is based on results from the phase 3 PROTECT study, which demonstrated a significantly smaller decline in beta cell function at 78 weeks compared with placebo.

Read more about the clinical data, safety considerations, and what this approval means for pediatric diabetes care.

https://hubs.li/Q04lry_r0

Researchers at CHOP have identified a high-risk immune endotype in children with multiple organ dysfunction syndrome (MO...
06/13/2026

Researchers at CHOP have identified a high-risk immune endotype in children with multiple organ dysfunction syndrome (MODS), with or without sepsis.

The study found that elevated IL-6 and IFN-γ signaling, along with persistent JAK/STAT pathway activation, were associated with more severe illness and worse outcomes.

“Our goal is not simply to know that some children are sicker than others, but to understand the biology driving that risk so future studies can test more precise approaches.”

Read the full story: https://hubs.li/Q04lggvD0

📱 New Surgeon General advisory: Excessive screen use may affect children's development, sleep, mental health, physical h...
06/12/2026

📱 New Surgeon General advisory: Excessive screen use may affect children's development, sleep, mental health, physical health, and academic performance.

But experts caution against viewing technology as the enemy.

"Technology is not inherently the boogeyman." — Jeff Temple, PhD

Read more about what pediatricians should know about recognizing problematic screen use and counseling families: https://hubs.li/Q04lgry50

Pediatricians are increasingly on the front lines of behavioral health care.New research from Megan Cole Brahim, PhD, an...
06/12/2026

Pediatricians are increasingly on the front lines of behavioral health care.

New research from Megan Cole Brahim, PhD, and team found that mental health-related diagnoses are being addressed more frequently during primary care visits, with anxiety showing nearly a 300% increase over the past decade.

The findings highlight the growing need for training, staffing, and integrated behavioral health resources within pediatric practices.

🔗 Read the full story: https://hubs.li/Q04lfrc80

🚨 FDA update: TOFIDENCE (tocilizumab-bavi; Organon) has received expanded indications for adults and pediatric patients ...
06/10/2026

🚨 FDA update: TOFIDENCE (tocilizumab-bavi; Organon) has received expanded indications for adults and pediatric patients aged 2 years and older with severe or life-threatening CAR T-cell–induced cytokine release syndrome (CRS) and for hospitalized patients with COVID-19 who require corticosteroids and respiratory support.

The approval adds a new biosimilar option across 2 critical inflammatory conditions.

https://hubs.li/Q04kWLm-0

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