Aging-US

06/04/2026

🧬 :
Dr. Josh Mitteldorf summarizes his perspective in Volume 17, Issue 5, titled “Methylation clocks for evaluation of anti-aging interventions.”

🎥 https://www.youtube.com/watch?v=efgNvr5ezTk

Dr. Josh Mitteldorf summarizes his research perspective published in Volume 17, Issue 5 of Aging (Aging-US), titled “Methylation clocks for evaluation of anti-aging interventions.”

06/03/2026

🎧 Listen to our on the paper, titled "Extracellular vesicles released by senescent myoblasts affect recipient cells via miRNA-target interactions."

https://soundcloud.com/aging-us/senescent-muscle-cells-send-molecular-messages-that-may-contribute-to-age-related-muscle-decline

BUFFALO, NY — June 3, 2026 — A new paper was in Volume 18 of Aging-US on May 15, 2026, titled “Extracellular vesicles released by senescent myoblasts affect recipient cells via mi

06/03/2026

🎥 :
Abstract about this paper in Volume 18, titled “Extracellular vesicles released by senescent myoblasts affect recipient cells via miRNA-target interactions.”
McMaster University

🔗 https://doi.org/10.18632/aging.206379

06/03/2026

🔆 :
This paper was in Volume 18, titled "Extracellular vesicles released by senescent myoblasts affect recipient cells via miRNA-target interactions."

⬇️
https://aging-us.net/2026/06/03/senescent-muscle-cells-send-molecular-messages-that-may-contribute-to-age-related-muscle-decline/

A new research paper was published in Volume 18 of Aging-US on May 15, 2026, titled “Extracellular vesicles released by senescent myoblasts affect recipient cells via miRNA-target interactions.”

06/03/2026

🔆 :
Figure 1 from the “Extracellular vesicles released by senescent myoblasts affect recipient cells via miRNA-target interactions,” in Volume 18.

Figure 1. Transwell culture with senescent myoblasts impairs myotube formation. (A) Representative phase contrast microscopy images of myoblasts stained for SA-β-gal at pH 6.0, captured 48h after dosing with vehicle (VEH) or bleomycin (BLEO). (B) Flow cytometry histograms of myoblasts stained with propidium iodide 48h after treatment. The fluorescent intensity of propidium iodide determines the cell cycle phase. (C) Relative mRNA expression of Cdkn1a (p21) following VEH or BLEO treatment. (D) Schematic diagram of myotubes exposed to SEN/NSEN myoblasts in a 0.4-μm transwell insert. This allows for intercellular communication exclusively through factors released into the cell culture media. Relative mRNA expression of senescence genes (E) Trp53 and (F) Cdkn1a in myotubes after 6 days of 0.4-μm transwell culture with NSEN or SEN myoblasts. (G) Representative immunofluorescence microscopy images of myotubes after co-culture with NSEN or SEN myoblasts. Myotubes are stained for MyHC (green) and nuclei (DAPI; blue). Graphical quantification of (H) myotube diameter, (I) myotube surface area, and (J) myonuclear index.

🔗 https://doi.org/10.18632/aging.206379

06/03/2026

🔆 :
A new paper was on May 15, 2026, titled “Extracellular vesicles released by senescent myoblasts affect recipient cells via miRNA-target interactions.”

Visit Volume 18 at Aging-US.com to read the full .

🔗 https://doi.org/10.18632/aging.206379

06/03/2026

, & :
Follow guidelines for ethical behavior and the International Committee of Medical Journal Editor's Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals.

https://www.aging-us.com/ethics

Ethics | Aging

06/03/2026

: "The love and hate relationship between cellular senescence and stemness"

DOI ⬇️
https://doi.org/10.18632/aging.206387

Cellular senescence and stemness represent two biological entities with several opposing properties. However, both senescence and stemness serve to maintain tissue homeostasis, via different mechani

06/03/2026

🧬 :
Dr. Leonid Peshkin discusses a perspective he co-authored, titled “On standardization of controls in lifespan studies.”

🎥 https://youtu.be/N_tL2aTN2Jw?si=PpEfvQffSQ_bpiJY

Dr. Leonid Peshkin from the Department of Systems Biology at Harvar...

06/02/2026

✅ Check out our post on: "Age-specific DNA methylation alterations in s***m at imprint control regions may contribute to the risk of autism spectrum disorder in offspring."

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https://aging-us.org/2026/02/epigenetic-changes-in-s***m-may-explain-association-between-paternal-age-and-autism-risk/

***m

While maternal health has traditionally been central to research on pregnancy and child development, there is growing recognition that paternal factors also play a role, particularly the father’s age. Several studies have found a modest increase in risk of neurodevelopmental conditions, including ...