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Journal of Applied Physiology

Journal of Applied Physiology The Journal of Applied Physiology publishes original papers that deal with diverse areas of research

Editor-in-Chief: Sue Bodine, MD
Full Editorial Board: https://www.physiology.org/jappl/edboard

Operating as usual

Physiology Educators: If you're going to , you can also attend the  pre-Summit workshop on Thurs. 4/20. You must registe...
03/17/2023

Physiology Educators: If you're going to , you can also attend the pre-Summit workshop on Thurs. 4/20. You must register for the workshop, but it's included in your Summit reg fees. Learn more: http://ow.ly/98RJ50Nfzfh

Muscle group-specific skeletal muscle : a five-year longitudinal study in septuagenariansMasatoshi Naruse, et al. http:/...
03/17/2023


Muscle group-specific skeletal muscle : a five-year longitudinal study in septuagenarians
Masatoshi Naruse, et al.
http://ow.ly/bGMW50Nh65N
Ball State University

New in Journal of Applied Physiology Progressive  training improves  psychophysiological outcomes in young adult  w/ a h...
03/16/2023

New in Journal of Applied Physiology
Progressive training improves psychophysiological outcomes in young adult w/ a history of adverse childhood experiences
http://ow.ly/vvkn50Nj8YF
University of Iowa The University of Oklahoma

Endothelin A Receptor Inhibition Increases Cutaneous Nitric Oxide-Dependent Vasodilation Independent of Superoxide in No...
03/16/2023


Endothelin A Receptor Inhibition Increases Cutaneous Nitric Oxide-Dependent Vasodilation Independent of Superoxide in Non-Hispanic Black Young Adults
Casey G. Turner, et al.
http://ow.ly/TPzb50Nh5Tv
Georgia State University

"Inhibiting regional sweat  modifies the ventilatory response to : interactions between core and skin temperature" By: J...
03/15/2023

"Inhibiting regional sweat modifies the ventilatory response to : interactions between core and skin temperature" By: Josh Foster, et al.
http://ow.ly/ukgf50Nh5Bm

“Hypercapnic signaling influences hypoxic signalingin the control of breathing in ”Paulina M. Getsy, et al. http://ow.ly...
03/15/2023


“Hypercapnic signaling influences hypoxic signalingin the control of breathing in ”
Paulina M. Getsy, et al.
http://ow.ly/e45T50Nh5cS
Case Western Reserve University

"Acute interleukin-6 modulates key enzymes involved in prefrontal cortex and hippocampal amyloid precursor protein proce...
03/14/2023


"Acute interleukin-6 modulates key enzymes involved in prefrontal cortex and hippocampal amyloid precursor protein processing" Daniel M. Marko, et al.
http://ow.ly/v3Mq50Nh4EL
Brock University

 Multi-omics profiling of the impact of an Angiotensin (1-7)-expressing probiotic combined with exercise training in age...
03/14/2023


Multi-omics profiling of the impact of an Angiotensin (1-7)-expressing probiotic combined with exercise training in aged male rats.
Liliana C. Baptista, et al.
http://ow.ly/McyP50Nh4az
UAB - The University of Alabama at Birmingham

 Renal blood flow during : understanding its measurement with Doppler ultrasound.  Marcos P. Rocha, et al. http://ow.ly/...
03/13/2023


Renal blood flow during : understanding its measurement with Doppler ultrasound. Marcos P. Rocha, et al.
http://ow.ly/YI1k50Nh3SE
UMass Boston

Our webinars are on a brief hiatus as we gear up for . Have you registered yet? We'd love to see you in Long Beach! Regu...
03/13/2023

Our webinars are on a brief hiatus as we gear up for . Have you registered yet? We'd love to see you in Long Beach! Regular reg rates through 3/31: http://ow.ly/AxuI50Ncuof

Lower-Limb Resistance Training Reduces Exertional  and Intrinsic Neuromuscular Fatigability in Individuals with .  Nicol...
03/13/2023

Lower-Limb Resistance Training Reduces Exertional and Intrinsic Neuromuscular Fatigability in Individuals with . Nicole M. Brunton, et al.
http://ow.ly/zBQR50Nh3xe

 “Biomarkers to measure respiratory muscle damage following inspiratory pressure-threshold loading in healthy young men”...
03/10/2023

“Biomarkers to measure respiratory muscle damage following inspiratory pressure-threshold loading in healthy young men” Muneeb Iqbal, et al.
http://ow.ly/ckIA50NaPOL
University of Southern Queensland - Australia

MARCH 2023 The Physiologist MagazineScience and Cycling: Creating Meaningful Connections by Lacy Alexander
03/09/2023
Science and Cycling: Creating Meaningful Connections

MARCH 2023 The Physiologist Magazine

Science and Cycling: Creating Meaningful Connections by Lacy Alexander

I attended my first APS meeting in San Diego in 2004. As a first-year doctoral trainee, I diligently prepared my three-minute presentation, anticipated every possible question about my data and even looked up pictures of the big names who might walk by my poster (my mentor trained me well). I was pa...

 “Effects of Biological S*x and Oral Contraceptive Pill Use on Cutaneous Microvascular Endothelial Function and Nitric O...
03/09/2023

“Effects of Biological S*x and Oral Contraceptive Pill Use on Cutaneous Microvascular Endothelial Function and Nitric Oxide-Dependent Vasodilation in Humans” Casey G. Turner, et al.
http://ow.ly/rang50NaPt7
Georgia State University

 “Effects of androgen excess and body mass index on endothelial function in women with polycystic o***y syndrome” Daniel...
03/08/2023

“Effects of androgen excess and body mass index on endothelial function in women with polycystic o***y syndrome” Danielle E. Berbrier, et al.
http://ow.ly/28QW50NaOTr
McGill University

 tolerance, fatigue, mental health, and employment status at 5 & 12 months following  illness in a physically trained po...
03/08/2023

tolerance, fatigue, mental health, and employment status at 5 & 12 months following illness in a physically trained population Journal of Applied Physiology

http://ow.ly/ESKN50NaR7X

 “The spatial temporal dynamics of pulmonary blood flow are altered in pulmonary arterial hypertension”Abhilash S. Kizha...
03/08/2023

“The spatial temporal dynamics of pulmonary blood flow are altered in pulmonary arterial hypertension”
Abhilash S. Kizhakke Puliyakote, et al.
http://ow.ly/Ngtv50NaOEf
UC San Diego

Last week's most mentioned article in news and social media is from Human skeletal muscle-specific atrophy with aging: a...
03/07/2023

Last week's most mentioned article in news and social media is from


Human skeletal muscle-specific atrophy with aging: a comprehensive review

http://ow.ly/ABH650N9FrK

 “Global deletion of CCL2 has adverse impacts on recovery of skeletal muscle fiber size and function and is muscle-speci...
03/07/2023

“Global deletion of CCL2 has adverse impacts on recovery of skeletal muscle fiber size and function and is muscle-specific” Patrick J. Ferrara, et al.
http://ow.ly/oRJK50NaOf3

 “Axial Stress Determines the Velocity of Shear Wave Propagation in Passive but not Active Muscles in vivo” Michel Berna...
03/07/2023

“Axial Stress Determines the Velocity of Shear Wave Propagation in Passive but not Active Muscles in vivo”
Michel Bernabei, et al.
http://ow.ly/K7Ib50NaNWG

Last month's most mentioned article is a 2016 APSselect article from Journal of Applied PhysiologyLifelong strength trai...
03/03/2023

Last month's most mentioned article is a 2016 APSselect article from Journal of Applied Physiology

Lifelong strength training mitigates the age-related decline in efferent drive

ow.ly/Ub0I50N5VuQ

 “Low-load blood flow-restricted resistance exercise produce fiber type-independent hypertrophy and improves muscle func...
03/03/2023

“Low-load blood flow-restricted resistance exercise produce fiber type-independent hypertrophy and improves muscle functional capacity in older individuals” Jakob Wang, et al.
http://ow.ly/crK650N3Fvb

 “Effects of co-morbid Type II Diabetes Mellitus and Heart Failure on Rat Hindlimb and Respiratory Muscle Blood Flow dur...
03/02/2023

“Effects of co-morbid Type II Diabetes Mellitus and Heart Failure on Rat Hindlimb and Respiratory Muscle Blood Flow during Treadmill Exercise" Alec L.E. Butenas, et al.
http://ow.ly/xRIs50N3EzJ

 “Human skeletal muscle-specific atrophy with : a comprehensive review” Masatoshi Naruse, et al. http://ow.ly/Cwvy50N3Eg...
03/01/2023

“Human skeletal muscle-specific atrophy with : a comprehensive review” Masatoshi Naruse, et al.
http://ow.ly/Cwvy50N3EgG

 “Limiting radial pedal forces greatly reduces maximal power output and efficiency in sprint cycling; an optimal control...
03/01/2023

“Limiting radial pedal forces greatly reduces maximal power output and efficiency in sprint cycling; an optimal control study” D. A. Kistemaker, et al.
http://ow.ly/KCcg50N3CUt

 “Case studies in physiology: is blackout in breath-hold diving related to cardiac arrhythmias?” Eric Mulder, et al. htt...
02/28/2023

“Case studies in physiology: is blackout in breath-hold diving related to cardiac arrhythmias?” Eric Mulder, et al.
http://ow.ly/bPO550N25ee

Timeline photos
02/28/2023

Timeline photos

Last week's most mentioned article in news and social media is from Journal of Applied Physiology:

A multi-trial, retrospective analysis of the antihypertensive effects of high-resistance, low-volume inspiratory muscle strength training

http://ow.ly/t03P50N3wYP

 “Assessing the Calculation of Scond and Sacin from Multiple Breath Washout Data”  G. Kim Prisk, et al. http://ow.ly/Kgx...
02/28/2023

“Assessing the Calculation of Scond and Sacin from Multiple Breath Washout Data” G. Kim Prisk, et al.
http://ow.ly/Kgx550N24kf

Researchers from Ball State University demonstrate in a new Journal of Applied Physiology paper that coconut sap powder,...
02/27/2023

Researchers from Ball State University demonstrate in a new Journal of Applied Physiology paper that coconut sap powder, a traditional Asian sweetener, lowers brachial systolic blood pressure and carotid artery mechanical stiffness in middle-aged and older adults

ow.ly/GVGP50N29b8

 “It is time to abandon single-value oxygen uptake energy equivalents” Pavreet K. Gill, et al. http://ow.ly/QNgf50N244f ...
02/27/2023

“It is time to abandon single-value oxygen uptake energy equivalents” Pavreet K. Gill, et al.
http://ow.ly/QNgf50N244f

 Journal of Applied Physiology study finds 8 weeks of concurrent exercise training was more helpful to people recovering...
02/27/2023

Journal of Applied Physiology study finds 8 weeks of concurrent exercise training was more helpful to people recovering from than World Health Organization (WHO)
rehab recommendations. Read press release: http://ow.ly/Ljqx50N0whg

 “Cholinergic nerve contribution to cutaneous active vasodilation during  is similar to whole-body passive heating” Mich...
02/27/2023

“Cholinergic nerve contribution to cutaneous active vasodilation during is similar to whole-body passive heating” Michael A. Francisco, et al.
http://ow.ly/jAeQ50N23LH

PRESS RELEASE: Personalized Exercise Program Improves Long COVID Symptoms - features research from Journal of Applied Ph...
02/24/2023
Personalized Exercise Program Improves Long COVID Symptoms

PRESS RELEASE: Personalized Exercise Program Improves Long COVID Symptoms - features research from Journal of Applied Physiology

Rockville, Md. (February 22, 2023)—A research team from the University of Murcia, Spain, found a supervised, eight-week exercise program improved symptoms of patients with long COVID better than the current standard self-managed rehabilitation recommendations. The study is published ahead of print...

 “Prolonged sitting and peripheral vascular function: potential mechanisms and methodological considerations” Elizabeth ...
02/22/2023

“Prolonged sitting and peripheral vascular function: potential mechanisms and methodological considerations” Elizabeth J. Pekas, et al.
http://ow.ly/gJlx50MUlet
University of Nebraska at Omaha

Congratulations to Journal of Applied Physiology February  winners Jimeno-Almazán et al. for “Effects of a concurrent tr...
02/21/2023

Congratulations to Journal of Applied Physiology February winners Jimeno-Almazán et al. for “Effects of a concurrent training, respiratory muscle exercise, and self-management recommendations on recovery from post-COVID-19 conditions”
http://ow.ly/r7qm50MNmmW

 “Measurement of 24-hour Continuous Human CH4 Release in a Whole Room Indirect Calorimeter” Elvis A. Carnero, et al. htt...
02/21/2023

“Measurement of 24-hour Continuous Human CH4 Release in a Whole Room Indirect Calorimeter” Elvis A. Carnero, et al.
http://ow.ly/zRKs50MUkXH

 “Limited effect of over-the-counter doses of ibuprofen on mechanisms regulating muscle hypertrophy during resistance tr...
02/20/2023

“Limited effect of over-the-counter doses of ibuprofen on mechanisms regulating muscle hypertrophy during resistance training in young adults” Mats Lilja, et al.
http://ow.ly/as9850MUkBC

 “Greater Aortic Perivascular Adipose Tissue Density is Associated with Aging, Aortic Stiffness and Central Blood Pressu...
02/17/2023

“Greater Aortic Perivascular Adipose Tissue Density is Associated with Aging, Aortic Stiffness and Central Blood Pressure in Humans” Bradley S. Fleenor, et al.
http://ow.ly/ySnx50MPtPY

 “Muscle disuse as hindlimb unloading in early postnatal mice negatively impacts grip strength in adult mice: A pilot st...
02/17/2023

“Muscle disuse as hindlimb unloading in early postnatal mice negatively impacts grip strength in adult mice: A pilot study” Paul T. Reidy, et al.
http://ow.ly/qi8u50MPtsj

 “Force potentiation during  contractions in rat skeletal muscle” Ole Emil Andersen, et al. http://ow.ly/JZEM50MPt9g
02/16/2023

“Force potentiation during contractions in rat skeletal muscle” Ole Emil Andersen, et al.
http://ow.ly/JZEM50MPt9g

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The COVID-19 vaccine does not impair the body’s physiological response to exercise, according to a new study out of The University of Arizona. The study is published ahead of print in the Journal of Applied Physiology and chosen as an APSselect for February. Learn more: https://bit.ly/3hFtjWQ
Middle-aged endurance athletes not only have better control of blood pressure than sedentary adults in the same age group. They also displayed comparable control to young adults, according to new results published in Journal of Applied Physiology.
https://bit.ly/3dzXz3B
New research published in Journal of Applied Physiology suggests one year of moderate-to-vigorous intensity aerobic exercise training improved cardiorespiratory fitness, cerebral blood flow regulation, memory and executive function in people with mild cognitive impairment. Learn more: https://www.physiology.org/detail/news/2021/07/06/one-year-of-aerobic-exercise-training-may-reduce-risk-of-alzheimer-s-in-older-adults?SSO=Y
Do you have a perspective on the academic biomedical research laboratory as a “small business”? You are invited to share your view on the topic by submitting a brief Commentary to Journal of Applied Physiology. Deadline: July 12, 2021
New research finds elite athletes have temporary mitochondrial impairment after intense workouts, suggesting they may need to be mindful about overtraining. The study is published ahead of print in the Journal of Applied Physiology.
A new study finds that manipulating the stiffness of the collagen-based support structure of airway cells could lead to a new treatment for asthma. The study is published ahead of print in the Journal of Applied Physiology. Learn more: https://www.physiology.org/detail/news/2021/06/09/collagen-stiffness-plays-role-in-asthma-could-lead-to-targeted-treatment?SSO=Y
"Inequity degrades our scientific community and our academic research mission.…[T]his opportunity for self-reflection and review within the IRB and IACUC only risks improving the access and support for all scientists engaged in human and animal research" — Sonnet S. Jonker, PhD, Cirila Estela Vasquez Guzman, PhD, and Belinda H. McCully, PhD, in an invited editorial for Journal of Applied Physiology on addressing structural racism within institutional bodies regulating research.
Sergio Caravita, MD, PhD, explains how anemia and muscle loss may play more of a role than lung damage in the reduced exercise capacity experienced by many people who have had COVID-19. The study is published ahead of print in the Journal of Applied Physiology. Learn more: https://www.physiology.org/detail/news/2021/05/13/lung-damage-not-the-culprit-for-post-covid-exercise-limitations?SSO=Y
Wondering where your science belongs? Chat with the editors of APS journals throughout Experimental Biology. Today:

► 11:30 a.m.–12 p.m. EDT: American Journal of Physiology - Cell Physiology, Editor-in-Chief: Josephine C. Adams, PhD; Incoming Editor-in-Chief: Liliana Schaefer, MD: https://bit.ly/3nuJvwd

► 12–12:30 p.m. EDT: Physiological Reviews, Editor-in-Chief: Sadis Matalon, PhD, ScDr, FAPS, https://bit.ly/3e0uQ9a

► 12:30–1 p.m. EDT: Journal of Applied Physiology, Editor-in-Chief: Sue C. Bodine, PhD, FAPS, https://bit.ly/3gKRsfr

► 1–1:30 p.m. EDT: Function, Editor-in-Chief: Ole H. Petersen, CBE, FRS, https://bit.ly/3t4aQqe

► 1:30–2 p.m. EDT: American Journal of Physiology - Renal Physiology, Editor-in-Chief: Heddwen L. Brooks, PhD, https://bit.ly/3xuNttm
The New York Times's Gretchen Reynolds covered new findings published in the Journal of Applied Physiology on how icing muscles after exercise effects healing at the microscopic level.

Find the original study here: https://journals.physiology.org/doi/abs/10.1152/japplphysiol.01069.2020
Congratulations Scott McGuire et al.! Their manuscript “Cardiopulmonary and metabolic physiology during hemodialysis and inter-/intra-dialytic exercise” was chosen as an APSselect article for April. (Read all of this month's selected articles at http://ow.ly/UrCr50EeIFd.)

From the authors: “This study is the first to directly compare cardiopulmonary and metabolic physiology during hemodialysis, intra-dialytic exercise and inter-dialytic exercise. Hemodialysis was associated with increased respiratory exchange ratio, blunted minute ventilation and impaired [oxygen] uptake and extraction.” Read the full article in the Journal of Applied Physiology.
📈 Does supplementary BFR training positively influence muscle adaptations?

Pignanelli et al. (2021) suggest that supplementary BFR training using a variety of exercise modalities can improve the training response of athletes in diverse disciplines.

➡️ Scroll through for the research summary.

Full review: https://bit.ly/3tYsPiV

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