01/14/2026
Preventing PJI: The Window of Opportunity - Dr. Johannes F. Plate emphasizes a critical truth in our latest Master Class: the first few hours after surgery represent the greatest window of opportunity to prevent periprosthetic joint infections, before planktonic bacteria form mature biofilms that resist antibiotics and evade the immune system. He explores NanoCept, an innovative antibacterial implant coating with covalently bonded molecules that kill bacteria on contact, achieving near 100% reduction of common pathogens in vitro. From Joseph Lister's 1860s cleanliness principles to cutting-edge nanotechnology, Dr. Plate charts the evolution of infection prevention strategies.