
05/28/2025
Matt Kaeberlein shares his thoughts on Therapeutic Plasma Exchange (TPE), a compelling area of longevity research that continues to gain traction.
A recent human trial found that TPE may significantly reduce biological age, based on DNA methylation clocks. While the findings are intriguing, Matt cautions against over-interpreting early data, pointing to the need for more rigorous, placebo-controlled studies and better biomarkers of aging.
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Circulate Health and Buck researchers find that TPE combined with immunoglobulin reduced biological age by more than 2.5 years on average.