Optispan Podcast

Optispan Podcast Optispan is a vision for what healthcare should be.

Join us on a journey of discovery as we explore the science of longevity and optimal healthspan ("Optispan").

Matt Kaeberlein shares his thoughts on Therapeutic Plasma Exchange (TPE), a compelling area of longevity research that c...
05/28/2025

Matt Kaeberlein shares his thoughts on Therapeutic Plasma Exchange (TPE), a compelling area of longevity research that continues to gain traction.

A recent human trial found that TPE may significantly reduce biological age, based on DNA methylation clocks. While the findings are intriguing, Matt cautions against over-interpreting early data, pointing to the need for more rigorous, placebo-controlled studies and better biomarkers of aging.

Read the full article here:

Circulate Health and Buck researchers find that TPE combined with immunoglobulin reduced biological age by more than 2.5 years on average.

Can psychedelics, plasma exchange, and hormone therapy play a role in longevity?Matt Kaeberlein and Dr. Kevin White brea...
05/12/2025

Can psychedelics, plasma exchange, and hormone therapy play a role in longevity?

Matt Kaeberlein and Dr. Kevin White break down their biggest takeaways from the Livelong Media Experience in Palm Beach, where clinicians, scientists, influencers, and entrepreneurs all came together to explore the future of aging.

From therapeutic plasma exchange and the challenges of misinformation in wellness, to bold new research in digital twins, this episode covers the exciting, the controversial, and everything in between.

Topics include:
— Biological age & plasma dilution therapy
— The crossover of TBI, psychedelics & aging research
— Hormone replacement myths vs. science
— Where health data, AI & longevity intersect

Which intervention are you most curious about?
Watch or listen now.

Subscribe to our channel: https://www.youtube.com/ Our Newsletter (It's Free): https://www.optispan.life/Matt Kaeberlein & Dr. Kevin White share ...

Eat. Sleep. Move. Connect.These four simple words define the pillars of healthspan at Optispan, and they might be a powe...
05/09/2025

Eat. Sleep. Move. Connect.

These four simple words define the pillars of healthspan at Optispan, and they might be a powerful framework for optimizing your longevity.

In this episode of the Aging Well Podcast, Matt Kaeberlein shares how he personally evaluates each pillar and where he’s focusing his energy next. From refining his diet to cutting back on alcohol to improve sleep, he opens up about the habits that have made the biggest impact, and the one area he’s still working on.

So we’d love to know: which of these pillars (eat, sleep, move, or connect) are you currently thriving in? And which one could use a little more love?

Watch more at The Aging Well Podcast,https://youtu.be/twe_xkNgmK0

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