Optispan Podcast

09/20/2025

What do serotonin receptors do? Dr. Matt Kaeberlein explains this and more, in a recent episode on the . Head on over to our youtube channel, spotify, or wherever you get your podcasts to check it out!

09/09/2025

In the most recent episode of the , Dr. Matt Kaeberlein sits down with Joel Jamieson to explore the science of heart rate variability and how it connects to longevity, recovery, and performance.

Joel shares his journey from training elite fighters to becoming a global authority on HRV training, emphasizing that healthspan is built on consistency, balance, and resilience rather than endless high-intensity workouts.
The discussion dives into why VO2 max is one of the strongest predictors of longevity, how the parasympathetic nervous system and vagus nerve health regulate stress and recovery, and why zone 2 cardio, metabolic flexibility, and steady improvements in cardiovascular health matter more than chasing short-term results.

This conversation reframes strength vs endurance, highlights key anti-aging biomarkers, and shows how recovery science can transform both athletes and everyday people seeking lasting health.

08/28/2025

: “Most peptides that are being used widely today, the science is not there.”

While peptides could have beneficial properties, we need more in-depth research before we start widely using them medically.

07/20/2025

Introducing: Longevity Myths Debunked!

With all the noise and misinformation out there in the and space, it’s difficult to separate fact from fiction. But we hope these infographics, with text supplied by Optispan founder and longevity scientist , will help.

Have a favorite (or least favorite) longevity myth of your own? Post it in the comments, and we’ll add it to the list!

07/20/2025

In a recent article published by CityBiz, Optispan founder and CEO answers several insightful questions about the origins of , its goals, and the longevity space as a whole.

Want to read the full interview? Use the link below or find it on our website!

http://citybiz.co/article/719097/qa-with-dr-matt-kaeberlein-world-renowned-longevity-expert-and-ceo-of-optispan/

https://www.optispan.life/news/citybiz-q-and-a-2025

07/20/2025

In our June 2025 newsletter, we have a segment dedicated to explaining the advanced diagnostic that Optispan uses, and why.

“Turning Advanced Biomarkers Into Everyday Action” by Dr. Nicki Byrne, MD, provides summaries of the function and purpose of biomarkers like ApoB, fasting insulin, cortisol, s*x hormones, and more. If you want to learn more about longevity biomarkers and preventative healthcare, we hope you’ll give it a read.

Find it in our newsletter (linked in our bio)

https://www.optispan.life/news/june-2025-newsletter

07/12/2025

In our past March 2025 newsletter, we highlighted a Scientific American article written by Optispan founder .

“A Practical Approach to Healthspan Medicine” introduces the foundations of longevity medicine, details Optispan’s approach and long-term goals, and provides explanations of frequently used vocabulary in the space. If you are looking to learn more about longevity science and Optispan, we suggest you give this article a read.

Find it in our newsletter (linked in our bio)

https://www.optispan.life/news/the-big-o-march-2025-newsletter

https://www.scientificamerican.com/custom-media/google-cloud/a-practical-approach-to-healthspan-medicine/

05/28/2025

Matt Kaeberlein shares his thoughts on Therapeutic Plasma Exchange (TPE), a compelling area of longevity research that continues to gain traction.

A recent human trial found that TPE may significantly reduce biological age, based on DNA methylation clocks. While the findings are intriguing, Matt cautions against over-interpreting early data, pointing to the need for more rigorous, placebo-controlled studies and better biomarkers of aging.

Read the full article here:

Circulate Health and Buck researchers find that TPE combined with immunoglobulin reduced biological age by more than 2.5 years on average.