David Nicklaus, St. Louis Post-Dispatch

David Nicklaus, St. Louis Post-Dispatch David Nicklaus, semi-retired but still writing, has covered St. Louis business for 4 decades.

STL startup Wugen has a promising cell treatment for highly deadly forms of leukemia and lymphoma, meeting "a huge unmet...
10/06/2025

STL startup Wugen has a promising cell treatment for highly deadly forms of leukemia and lymphoma, meeting "a huge unmet medical need."

Wugen has become a standout among St. Louis biotech startups. It has raised more than $300 million in capital since 2018 and employs about 35 people.

The IN2 incubator, which has provided a boost to 10 St. Louis ag startups, is changing its name to HARVEST AgTech and mo...
09/23/2025

The IN2 incubator, which has provided a boost to 10 St. Louis ag startups, is changing its name to HARVEST AgTech and moving its HQ from Colorado to STL.

The former Wells Fargo Innovation Incubator, known as IN2, will now be called HARVEST AgTech and run by Yield Lab Institute, an affiliate of Creve Coeur investment firm Yield Lab.

Alex Quinn sold his first startup at age 23. He now heads Authentic Interactions, which lets people produce a holographi...
08/25/2025

Alex Quinn sold his first startup at age 23. He now heads Authentic

Interactions, which lets people produce a holographic "twin" that's able to carry on a conversation

“We can be a $1 billion artificial intelligence company that's known as one of the best AI companies in the world, focused on authenticity and safety.”

AGs accuse Wall Street giants of conspiring to kill the coal industry, but there's a simpler reason why production is do...
07/28/2025

AGs accuse Wall Street giants of conspiring to kill the coal industry, but there's a simpler reason why production is down: Power plants are burning less of the stuff.

Coal's economic challenges forced Peabody and several competitors into bankruptcy in recent years.

The St. Louis Fed building, hailed as a "veritable strongbox" in downtown STL, turns 100 this month. The institution has...
06/03/2025

The St. Louis Fed building, hailed as a "veritable strongbox" in downtown STL, turns 100 this month. The institution has had a big effect on monetary policy, and on how we learn about the economy

The Federal Reserve Bank of St. Louis, which marks its centennial at its current headquarters, continues to play a large role in the region’s, and nation’s, economy.

I covered the first InvestMidwest in 2000 and have watched the conference's impact grow for 25 years. It has connected h...
05/09/2025

I covered the first InvestMidwest in 2000 and have watched the conference's impact grow for 25 years. It has connected hundreds of entrepreneurs with investors, helping startups raise almost $5 billion.

Since InvestMidwest was founded 25 years ago to focus attention on what most venture capitalists once considered flyover country, participating companies have raised nearly $5 billion in capital.

In his first local interview, St. Louis Fed President Alberto Musalem shares his views on monetary policy and says they'...
01/16/2025

In his first local interview, St. Louis Fed President Alberto Musalem shares his views on monetary policy and says they're shaped partly by discussions with district residents.

Approaching his first meeting as a voting member of the Federal Reserve’s key policy body, Alberto Musalem says he’s optimistic about the economy but keeping a wary eye on inflation.

What comes next after two straight years of 20%-plus gains in the stock market? Because it's so rare, history doesn't gi...
01/05/2025

What comes next after two straight years of 20%-plus gains in the stock market? Because it's so rare, history doesn't give us much of a clue.

The Standard & Poor's 500 index now trades for nearly 30 times as much as its companies earned in profits this year.

Remember voodoo economics? This year, much of what we're hearing from the presidential candidates amounts to cuckoo econ...
09/29/2024

Remember voodoo economics? This year, much of what we're hearing from the presidential candidates amounts to cuckoo economics.

Many of the ideas coming from Kamala Harris and Donald Trump seem less about sensible policy than about pandering to specific voting groups.

Nippon Steel says it will invest billions in US Steel's aging plants, but Biden plans to block the deal. The political s...
09/13/2024

Nippon Steel says it will invest billions in US Steel's aging plants, but Biden plans to block the deal. The political storm creates uncertainty for thousands of employees.

Opposition to a Japanese company buying U.S. Steel is bipartisan: Both Donald Trump and Kamala Harris have vowed to keep the steelmaker in American hands.

The newly opened Gates Ag One headquarters is a big win for St. Louis as the region emerges as a leading center for agri...
04/15/2024

The newly opened Gates Ag One headquarters is a big win for St. Louis as the region emerges as a leading center for agribusiness and ag research.

On average, a small farmer in Africa produces just one-fifth as much output per acre as his North American counterpart.

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