The American Journal of Pathology

16/09/2025

: Classification and Quantification of Pejorative and Nonpejorative Architectures in Resected Hepatocellular Carcinoma from Digital Histopathologic Images. Authors from Université Paris-Saclay, GHU APHP. Mondor

Free in the : https://ajp.amjpathol.org/article/S0002-9440(24)00206-2/fulltext

15/09/2025

Metabolic dysfunction-associated steatotic liver disease in patients and mouse with Wilson’s disease.

text: https://ajp.amjpathol.org/article/S0002-9440(25)00191-9/fulltext

13/09/2025

: Local Tetanus Begins with a Neuromuscular Junction Paralysis around the Site of Tetanus Neurotoxin Release due to Cleavage of the Vesicle-Associated Membrane Protein. Authors from University of Padova and UCL

Free in the : https://ajp.amjpathol.org/article/S0002-9440(24)00208-6/fulltext

12/09/2025

Single-Cell Sequencing Has Revealed the Palmitoylation Landscape in Lung Adenocarcinoma and Identified ABHD17C as a Novel Biomarker

Full text:

Protein S-palmitoylation, a reversible posttranslational modification, is crucial for tumor progression. However, the palmitoylation landscape in tumor cells and its variability within different tumor cell populations remain underexplored. This study was designed to analyze protein palmitoylation us...

11/09/2025

: S*x Differences in Impacts of Early Gestational and Peri-Adolescent Ozone Exposure on Lung Development in Rats. From American Society for Investigative Pathology member Dr. Janice Dye and colleagues at the U.S. Environmental Protection Agency and the Oak Ridge Institute for Science and Education.

Free in the :

Air pollution exposure during pregnancy may affect fetal growth. Fetal growth restriction (FGR) is associated with reduced lung function in children that can persist into adulthood. Using an established model of asymmetrical FGR in Long-Evans rats, this study investigated s*x differences in effects....

11/09/2025

: Aldehyde dehydrogenase 2 deficiency impairs liver progenitor cell proliferation in alcohol-fed mice.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00326-8/fulltext

10/09/2025

: Novel Perineural Pathways and the Dynamics of SIV-Infected Macrophage Trafficking Out of the Central Nervous System. Authors from Boston College, the Tulane National Primate Research Center at Tulane University, and Cornell University

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00325-6/fulltext

10/09/2025

Super-resolution microscopy reveals alterations in clathrin structure in human cancer tissue. Authors from UCL, IPO-Porto, Universidade do Porto, and the The University of Edinburgh.

text: https://ajp.amjpathol.org/article/S0002-9440(25)00190-7/fulltext

09/09/2025

: Bifidobacterium bifidum Strain BB1 Inhibits Tumor Necrosis Factor-α–Induced Increase in Intestinal Epithelial Tight Junction Permeability via Toll-Like Receptor-2/Toll-Like Receptor-6 Receptor Complex–Dependent Stimulation of Peroxisome Proliferator-Activated Receptor γ and Suppression of NF-κB p65. Authors from Penn State College of Medicine.

Free in the : https://loom.ly/ClBuIpw

08/09/2025

Early endosome disturbance and endolysosomal pathway dysfunction in .

Authors from the Sorbonne Université, Université Paris-Est Créteil (UPEC), Nantes Université and Hôpital Pitié Salpêtrière, AP-HP

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00189-0/fulltext

06/09/2025

: Apoptosis Signal-Regulated Kinase-1 Promotes Nucleus Pulposus Cell Senescence and Apoptosis to Regulate Intervertebral Disc Degeneration

Free in the : https://ajp.amjpathol.org/article/S0002-9440(24)00203-7/fulltext

05/09/2025

Nitric Oxide may Adversely Affect the Metabolism and Viability of Retinal Organoids Derived from Patients with Leber Hereditary Optic Neuropathy. Authors from the Kobe University Graduate School of Medicine.

text:

Leber hereditary optic neuropathy (LHON) is a bilateral optic neuropathy associated with mitochondrial DNA (mtDNA) mutations characterized by parapapillary telangiectasia during the acute phase. However, its precise mechanism remains unclear. This study evaluated the effects of nitric oxide (NO) on....