The American Journal of Pathology

12/15/2025

Stromal SRD5A2 promotes prostate growth through WNT5A-LEF1-IGF1 signaling in benign prostatic hyperplasia. From American Society for Investigative Pathology member Zongwei Wang and colleagues from Beth Israel Deaconess Medical Center at Harvard Medical School, College of Natural Sciences, UT Austin, and Washington University in St. Louis.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00338-4/fulltext

12/12/2025

SCG2 transcriptionally activated by SP1 promotes nasal epithelial cell proliferation and epithelial mesenchymal transition

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00333-5/fulltext

12/11/2025

: Histopathologic Differential Diagnosis and Estrogen Receptor/Progesterone Receptor Immunohistochemical Evaluation of Breast Carcinoma Using a –Based Artificial Intelligence Architecture.

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In breast carcinoma, invasive ductal carcinoma (IDC) is the most common histopathologic subtype, and ductal carcinoma in situ (DCIS) is a precursor of IDC. These two often occur concomitantly. The immunohistochemical staining of estrogen receptor (ER)/progesterone receptor (PR) in IDC/DCIS on histop...

12/10/2025

Growth differentiation factor 11 attenuates photoaging through ferroptosis pathway in SZ95 sebocytes. Authors from Harbin Medical University and Medizinische Hochschule Brandenburg Theodor Fontane

text: https://ajp.amjpathol.org/article/S0002-9440(25)00332-3/fulltext

12/09/2025

: Tumor-Derived Immunoglobulin-Like Transcript 4 Promotes Postoperative Relapse via Inducing Vasculogenic Mimicry through MAPK/ERK Signaling in Hepatocellular Carcinoma.

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The efficacy of conventional anti-angiogenesis drugs is usually low in treating hepatocellular carcinoma (HCC). Therefore, there is an urgent need to find new precise therapeutic targets and to develop more effective drugs for the treatment of HCC. Vasculogenic mimicry (VM) is different from classic...

12/08/2025

The role of extracellular vesicle-derived miRNA in the atherosclerotic burden. Authors from Università degli Studi di Milano and the Università degli Studi di Brescia

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00330-X/fulltext

12/05/2025

From Theory to Practice: A Comprehensive Review of Pseudomyxoma Peritonei Research and Its Implications for Future Treatment.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00329-3/fulltext

12/04/2025

A Seminal Work That Defined the Pathology of Frontotemporal Dementias and the Concept of TDP-43 Proteinopathies

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00357-8/fulltext

12/04/2025

: Lipopolysaccharide Triggers Luminal Acidification to Promote Defense Against Bacterial Infection in Vaginal Epithelium.

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The vaginal epithelium plays pivotal roles in host defense against pathogen invasion, contributing to the maintenance of an acidic microenvironment within the vaginal lumen through the activity of acid-base transport proteins. However, the precise defense mechanisms of the vaginal epithelium after a...

12/03/2025

Laminin Receptors in Peripheral Tissues --- Functions Revealed by Analysis of Knockout Mice. From American Society for Investigative Pathology member Dr. Yao Yao and colleagues from USF Health Taneja College of Pharmacy and USF Health-University of South Florida.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00331-1/fulltext

12/02/2025

: Spatial Transcriptomics Reveals the Transcriptomic Signatures in a Mouse Model of Pediatric Metabolic Dysfunction–Associated Steatohepatitis. Authors from Shanghai Jiao Tong University

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Metabolic dysfunction–associated steatohepatitis (MASH) is considered the progressive form of metabolic dysfunction–associated steatotic liver disease, which is the leading cause of chronic liver disease in children. However, the pathogenesis of pediatric MASH remains poorly understood because o...

12/02/2025

The American Journal of Pathology and the American Society for Investigative Pathology: Forging the Next Century of Insights into Mechanisms of Disease

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00373-6/fulltext