The American Journal of Pathology

11/26/2025

The Proteostasis Network in Proteinopathies: Mechanisms and Interconnections. Authors from Medical University of South Carolina (MUSC).

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00300-1/fulltext

11/24/2025

Uncovering the Unique Roles of Cathepsins B and L in Purkinje cells using Nervous System-specific CTSB and CTSL Double-deficient Mice. Authors from 順天堂/Juntendo Univ and Hyogo University.

Full text:

Defects in the autophagy-lysosomal degradation pathway contribute to neurodegenerative diseases. Cathepsins B (CtsB) and L (CtsL) are major lysosomal cysteine proteases. Mice deficient in both CtsB and CtsL exhibit abnormalities not only in neural tissue but in other organs, such as heart and liver,...

11/21/2025

Novel Kinesin Family 1A Variants Linked to Atypical Parkinsonism Elicit Altered Neuronal TDP-43 Interactions and Dendritic Atrophy. From American Society for Investigative Pathology member author Dr. Charleen Chu and colleagues from Pitt School of Medicine

text: https://ajp.amjpathol.org/article/S0002-9440(25)00204-4/fulltext

11/19/2025

P-Glycoprotein Drives Glioblastoma Survival and Chemotherapy Resistance: Potential as a Promising Liquid Biopsy Biomarker. Authors from UFRJ - Universidade Federal do Rio de Janeiro.

Full text:

Drug resistance is a major challenge in cancer therapy, and the expression of efflux pumps such as P-glycoprotein (P-gp, ABCB1) often correlates with poor prognosis in various tumors, including glioblastoma (GB). Considering that different roles for these proteins have been established in the biolog...

11/17/2025

Theme Review: Multiple Roles for Neuregulins and their ERBB Receptors in Neurodegenerative Disease Pathogenesis and Therapy. From American Society for Investigative Pathology member author Dr. Steve Carroll and colleagues from MUSC College of Medicine.

Free to read:

The role that neurotrophins, such as nerve growth factor, play in the pathogenesis of neurodegenerative diseases has long been appreciated. However, the neuregulin (NRG) family of growth factors and/or their v-erb-B2 avian erythroblastic leukemia viral oncogene homolog (ERBB) receptors have also bee...

11/17/2025

: Inactivation of Atp7b Copper Transporter in Intestinal Epithelial Cells Is Associated with Altered Lipid Processing and Cell Growth Machinery Independent from Hepatic Copper Accumulation and Severity of Liver Histology. Authors from UC Davis and Johns Hopkins Medicine.

text: https://ajp.amjpathol.org/article/S0002-9440(25)00379-7/fulltext

11/15/2025

Novel Perineural Pathways and the Dynamics of SIV-Infected Macrophage Trafficking Out of the Central Nervous System. Authors from Boston College, the Tulane National Biomedical Research Center at University, and Cornell University

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00325-6/fulltext

11/14/2025

: Specialized Pro-Resolving Mediators MaR1 and LXA4 Resolve Inflammation During Acute Chemical Lung Injury in the Absence of Neutrophils. From American Society for Investigative Pathology member William Muller and colleagues from Northwestern University Feinberg School of Medicine.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00377-3/fulltext

11/14/2025

Theme Review: Shared Mechanisms of Blood-Brain Barrier Dysfunction and Neuroinflammation in and . Authors from the Tulane National Biomedical Research Center at Tulane University.

Free to read:

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlighted the virus's impact on the central nervous system and its potential to exacerbate neurodegenerative diseases, similar to that in Alzheimer disease (AD). Emerging evide...

11/13/2025

: The miR-665/SOST Axis Regulates the Phenotypes of Bone Marrow Mesenchymal Stem Cells and Osteoporotic Symptoms in Female Mice

Free in the :

Osteoporosis is a common degenerative skeletal disease among older people, especially postmenopausal women. Bone marrow mesenchymal stem cells (BMSCs), the progenitors of osteoblasts, are essential to the pathophysiology of osteoporosis. Herein, targeting miRNAs with differential expression in dysfu...

11/12/2025

Theme Review: The Biological Intersection Between Chemotherapy-Related Cognitive Impairment and . Authors from Baylor College of Medicine, Texas Children's Hospital, Brigham and Women's Hospital and Harvard Medical School.

text:

Alzheimer disease (AD) is the most common type of dementia and one of the leading causes of death in elderly patients. The number of patients with AD in the United States is projected to double by 2060. Thus, understanding modifiable risk factors for AD is an urgent public health priority. In parall...

11/11/2025

: Intestinal Dysbacteriosis Contributes to Persistent Cognitive Impairment after Resolution of Acute Liver Failure.

Full text:

Regulating the gut microbiota alleviates hepatic encephalopathy (HE). Whether it is imperative to withhold treatment for microbial imbalance after liver functional recovery remains unclear. The aim of this work was to elucidate the alterations in cognitive behavior, liver function, synaptic transmis...