The American Journal of Pathology

12/22/2025

The Gut Microbiome as a Possible Mediator in Autoimmunity and Cardiovascular Disease: Shared Pathways and Therapeutic Implications. From American Society for Investigative Pathology member Massimiliano M. Corsi-Romanelli and colleagues from Università degli Studi di Perugia, Università degli Studi di Milano and the Istituto Auxologico Italiano.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00358-X/fulltext

12/19/2025

: Improving Colorectal Cancer Screening and Risk Assessment through Predictive Modeling on Medical Images and Records. Authors from Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center and Dartmouth.

text: https://ajp.amjpathol.org/article/S0002-9440(25)00380-3/fulltext

12/19/2025

Interplay between Leptin and Stearoyl-CoA Desaturase 1 in Estrogen Receptor-positive Breast Cancer Cells. Authors from Università della Calabria, Università di Siena, Università degli Studi di Milano, The Royal, and The University of Salford

text: https://ajp.amjpathol.org/article/S0002-9440(25)00336-0/fulltext

12/17/2025

Cross-Modality Learning for Predicting IHC Biomarkers from H&E-Stained Whole-Slide Images. Authors from Dartmouth, Geisel School of Medicine at Dartmouth, Dartmouth Hitchcock Medical Center

text: https://ajp.amjpathol.org/article/S0002-9440(25)00341-4/fulltext

12/15/2025

Stromal SRD5A2 promotes prostate growth through WNT5A-LEF1-IGF1 signaling in benign prostatic hyperplasia. From American Society for Investigative Pathology member Zongwei Wang and colleagues from Beth Israel Deaconess Medical Center at Harvard Medical School, College of Natural Sciences, UT Austin, and Washington University in St. Louis.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00338-4/fulltext

12/12/2025

SCG2 transcriptionally activated by SP1 promotes nasal epithelial cell proliferation and epithelial mesenchymal transition

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00333-5/fulltext

12/11/2025

: Histopathologic Differential Diagnosis and Estrogen Receptor/Progesterone Receptor Immunohistochemical Evaluation of Breast Carcinoma Using a –Based Artificial Intelligence Architecture.

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In breast carcinoma, invasive ductal carcinoma (IDC) is the most common histopathologic subtype, and ductal carcinoma in situ (DCIS) is a precursor of IDC. These two often occur concomitantly. The immunohistochemical staining of estrogen receptor (ER)/progesterone receptor (PR) in IDC/DCIS on histop...

12/10/2025

Growth differentiation factor 11 attenuates photoaging through ferroptosis pathway in SZ95 sebocytes. Authors from Harbin Medical University and Medizinische Hochschule Brandenburg Theodor Fontane

text: https://ajp.amjpathol.org/article/S0002-9440(25)00332-3/fulltext

12/09/2025

: Tumor-Derived Immunoglobulin-Like Transcript 4 Promotes Postoperative Relapse via Inducing Vasculogenic Mimicry through MAPK/ERK Signaling in Hepatocellular Carcinoma.

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The efficacy of conventional anti-angiogenesis drugs is usually low in treating hepatocellular carcinoma (HCC). Therefore, there is an urgent need to find new precise therapeutic targets and to develop more effective drugs for the treatment of HCC. Vasculogenic mimicry (VM) is different from classic...

12/08/2025

The role of extracellular vesicle-derived miRNA in the atherosclerotic burden. Authors from Università degli Studi di Milano and the Università degli Studi di Brescia

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00330-X/fulltext

12/05/2025

From Theory to Practice: A Comprehensive Review of Pseudomyxoma Peritonei Research and Its Implications for Future Treatment.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00329-3/fulltext

12/04/2025

A Seminal Work That Defined the Pathology of Frontotemporal Dementias and the Concept of TDP-43 Proteinopathies

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00357-8/fulltext