The American Journal of Pathology

27/03/2023

Glial, neuronal, vascular, RPE and inflammatory cell damage in a new Western diet-induced primate model of diabetic retinopathy

: Glial, neuronal, vascular, RPE and inflammatory cell damage in a new Western diet-induced primate model of . Authors from University of Sydney, UAB - The University of Alabama at Birmingham, University of Canberra and Oregon Health & Science University (OHSU).

This study investigated retinal changes in a Western diet (WD)-induced non-human primate (NHP) model of Type 2 diabetes (T2D). Rhesus NHP aged 15-17 years old were fed a high fat diet (n=7) for more than 5 years with the aim of reflecting the traditional WD. Age-matched controls (n=6) were fed a sta...

24/03/2023

: Inhibition of a Microbiota-derived Peptide Ameliorates Established Acute Lung Injury. Authors from Mei University and the University of Illinois Urbana-Champaign

text: https://ajp.amjpathol.org/article/S0002-9440(23)00113-X/fulltext

24/03/2023

Welcome to the newly elected leaders of American Society for Investigative Pathology! The American Journal of Pathology is happy to have Dr. Heather Francis as the upcoming Publications Committee Chair, and our Associate Editor Dr. Andrei Ivanov at the helm of the Program Committee.

Congratulations to the newly elected members of ASIP Leadership, Meritorious Awards Committee, and Nominating Committee! New terms will begin on July 1. Thanks to all of the regular and NextGen members that participated in the election by voting.

23/03/2023

Fibroblast Programmed Cell Death Ligand 1 Promotes Osteoclastogenesis in Odontogenic Keratocysts

"Fibroblast Programmed Cell Death Ligand 1 Promotes in Odontogenic ", new from American Society for Investigative Pathology member author Dr. Yu Cai and colleagues from Penn Biology (University of Pennsylvania) and Wuhan University.

Local aggressive growth of odontogenic keratocysts (OKCs) can cause serious bone destruction, even resulting in pathologic fractures of the mandible. The mechanism of osteoclastogenesis in OKCs was explored by investigating the role of programmed cell death ligand 1 (PD-L1), a key immune checkpoint,...

22/03/2023

Cancer Antigen 125 Expression Enhances the Gemcitabine/Cisplatin-Resistant Tumor Microenvironment in Bladder Cancer

"Cancer Antigen 125 Expression Enhances the Gemcitabine/Cisplatin-Resistant Tumor Microenvironment in Bladder Cancer" from American Society for Investigative Pathology member author Dr. Morihiro Higashi and colleagues from Saitama Medical Center.

Cancer antigen 125 (CA125) is one of the mucin family proteins and is a serum tumor marker for various tumors, such as ovarian cancer, endometrial cancer, pancreatic cancer, and bladder cancer. CA125 is used to distinguish between benign and malignant tumors, monitor the response to chemotherapy, an...

21/03/2023

Mice with Established Diabetes Show Increased Susceptibility to Renal Ischemia/Reperfusion Injury

: Mice with Established Diabetes Show Increased Susceptibility to Renal Ischemia/Reperfusion Injury: Protection by Blockade of Jnk or Syk Signaling Pathways. Authors include The American Journal of Pathology Associate Editor Dr. David Nikolic-Paterson and colleagues from Monash University, Monash Health, and The Second Affiliated Hospital of Xi’an Jiaotong University.

Free in the :

Patients with diabetes are at an increased risk for acute kidney injury (AKI) after renal ischemia/reperfusion injury (IRI). However, there is a lack preclinical models of IRI in established diabetes. The current study characterized renal IRI in mice with established diabetes and investigated potent...

15/03/2023

Attention American Society for Investigative Pathology members- today is the last day to vote in the 2023 election. See details in the post below to finalize your ballot.

REMINDER ASIP REGULAR & NEXT-GENERATION MEMBERS: Ballots are due TODAY (3/15)—Make your voice heard!

Official ballots were delivered via email from "Association Voting." Check your spam folder if you did not receive it, or contact Lisa McFadden [email protected].

http://bit.ly/3DqHp9S

15/03/2023

TGF-beta1 Regulates Peroxisomal Genes/Proteins via Smad Signaling in Fibroblasts and Transgenic Mouse Models. FREE Editor's Choice article from authors at Justus-Liebig-Universität Gießen (JLU), Children's Hospital Los Angeles, Inserm, and Univ of Giessen and Marburg Lung Ctr. https://ajp.amjpathol.org/article/S0002-9440(22)00392-3/fulltext.

14/03/2023

Deficiency of the Planar Cell Polarity Protein Intu Delays Kidney Repair and Suppresses Renal Fibrosis after Acute Kidney Injury

"Deficiency of the Planar Cell Polarity Protein Intu Delays Kidney Repair and Suppresses after Acute Kidney Injury". From American Society for Investigative Pathology member author Dr. Zheng D**g and colleagues from Augusta University, Penn State Eberly College of Science, Huck Institutes of the Life Sciences, and the Charlie Norwood VA Medical Center.

Planar cell polarity (P*P), a process of coordinated alignment of cell polarity across the tissue plane, may contribute to the repair of renal tubules after kidney injury. Intu is a key effector protein of P*P. Herein, conditional knockout (KO) mouse models that ablate Intu specifically from kidney....

13/03/2023

: vasculopathy in a Syrian golden hamster model. From authors at UC Davis School of Veterinary Medicine (UC Davis) and the U.S. Army Veterinary Corps.

Free text: https://ajp.amjpathol.org/article/S0002-9440(23)00082-2/fulltext

09/03/2023

Timeline photos

Have you registered for next week's Young Investigator Seminar featuring Dr. Michele Alves from the Ohio State University College of Medicine? Join us on March 16 for her talk "Mechanisms of Autonomic Nervous System Dysfunction in Neonatal Sepsis" http://bit.ly/3Ztn7oW

08/03/2023

Submit your discoveries in to The American Journal of Pathology- submission is free for all article types! : 5.770

https://www.editorialmanager.com/ajpa/default2.aspx

07/03/2023

The next AJP Featured Author Seminar is on Tuesday, March 21! Check out this preview from Dr. Charleen Chu from the Pitt School of Medicine. Check out a preview https://youtu.be/2Pa6tH25JtE

Register here https://bit.ly/3marR4q


The American Journal of Pathology

07/03/2023

Deep Learning–Based Objective and Reproducible Osteosarcoma Chemotherapy Response Assessment and Outcome Prediction

"–Based Objective and Reproducible Chemotherapy Response Assessment and Outcome Prediction", from American Society for Investigative Pathology and The American Journal of Pathology member Dr. Meera Hameed and colleagues from Memorial Sloan Kettering Cancer Center and Icahn School of Medicine at Mount Sinai.

Osteosarcoma is the most common primary bone cancer, whose standard treatment includes pre-operative chemotherapy followed by resection. Chemotherapy response is used for predicting prognosis and further management of patients. Necrosis is routinely assessed after chemotherapy from histology slides....

02/03/2023

New month, new ! The March 2022 issue of The American Journal of Pathology is now fully free in the .

Full issue: https://ajp.amjpathol.org/issue/S0002-9440(21)X0015-6

01/03/2023

The March issue of The American Journal of Pathology is now live!

Full issue: https://ajp.amjpathol.org/issue/S0002-9440(22)X0004-7

On the cover: Occludin staining of rapamycin treated intestine

28/02/2023

iPSC-Derived Neurons from Patients with POLG Mutations Exhibit Decreased Mitochondrial Content and Dendrite Simplification

"iPSC-derived neurons from patients with POLG mutations exhibit decreased mitochondrial content and dendrite simplification". From American Society for Investigative Pathology member Dr. Charlene Chu and coauthors from UPMC, Pitt School of Medicine, Perelman School of Medicine at the University of Pennsylvania, Pitt Public Health, and Children's Hospital of Philadelphia.

Mutations in POLG, the gene encoding the catalytic subunit of DNA polymerase gamma, result in clinical syndromes characterized by mitochondrial DNA (mtDNA) depletion in affected tissues with variable organ involvement. The brain is one of the most affected organs, and symptoms include intractable se...

27/02/2023

Placental Inflammation Significantly Correlates with Reduced Risk for Retinopathy of Prematurity

: Placental Inflammation Significantly Correlates with Reduced Risk for of Prematurity. Authors from The University of Utah, University at Buffalo, Medical University of South Carolina (MUSC), Huntsman Cancer Institute and the Jacobs School of Medicine and Biomedical Sciences.

Retinopathy of prematurity (ROP), a blinding condition affecting preterm infants, is an interruption of retinal vascular maturation which is incomplete when born preterm birth. Although ROP demonstrates delayed onset following preterm birth, representing a window for therapeutic intervention, we can...

23/02/2023

Reduction of Endothelial Glycocalyx on Peritubular Capillaries in Chronic Kidney Disease

"Reduction of Endothelial on Peritubular Capillaries in Chronic Kidney Disease". Authors from Institute of Pathology, the Division of Nephrology and Immunology, and the Electron Microscopy Facility of RWTH Aachen University.

In chronic kidney disease (CKD), peritubular capillaries undergo anatomic and functional alterations, such as rarefaction and increased permeability. The endothelial glycocalyx (EG) is a carbohydrate-rich gel-like mesh, which covers the luminal surface of endothelial cells. It is involved in many re...

22/02/2023

Selective modulation of the keratoconic stromal microenvironment by FSH and LH

: Selective modulation of the keratoconic stromal microenvironment by FSH and LH. Authors from North Texas Eye Research Institute, The University of North Texas Health Science Center at Fort Worth, and the Dean McGee Eye Institute at OU Health.

Free text:

Keratoconus (KC) affects corneal structure, resulting in thinning and bulging outward into a cone shape. Irregular astigmatism and decreased visual acuity appear during puberty and progress into the mid-30s, with unpredictable disease severity. The cause of KC is recognized as multifactorial, but re...

17/02/2023

Transcriptional profiling supports the notochordal origin of chordoma and its dependence on a TGFΒ1-TBXT network.

: Transcriptional profiling supports the notochordal origin of chordoma and its dependence on a TGFΒ1-TBXT network. Authors from Massachusetts General Hospital, Harvard Medical School, and the MIT Koch Institute for Integrative Cancer Research.

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Chordoma is a rare malignant tumor demonstrating notochordal differentiation. It is dependent on Brachyury (TBXT), a hallmark notochordal gene and transcription factor, and shares histological features and the same anatomical location as the notochord. In this study, we perform a molecular compariso...

16/02/2023

Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of Periodontitis

"Suppression of the NLRP3 Inflammasome through Activation of the Transient Receptor Potential Channel Melastatin 2 Promotes Osteogenesis in Tooth Extraction Sockets of ", authors from Tongji University and the Shanghai Engineering Research Center of Tooth Restoration and Regeneration.

This study explored the role of transient receptor potential channel melastatin 2 (TRPM2)-mediated activation of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome in osteogenesis during healing of tooth extraction sockets. Tooth extraction socket tissue samples were collected fr...

15/02/2023

13/02/2023

Gut Microbiome and Retinopathy of Prematurity

: Gut Microbiome and Retinopathy of Prematurity. Authors from The University of Chicago Pritzker School of Medicine and The University of Chicago.

Retinopathy of prematurity (ROP), a leading cause of childhood blindness worldwide, is strongly associated with gestational age and weight at birth. Yet, many extremely preterm infants never develop ROP or develop only mild ROP with spontaneous regression. In addition, a myriad of other factors play...

10/02/2023

Circulating α-Klotho counteracts TGF-β-induced sarcopenia

: Circulating α-Klotho counteracts TGF-β-induced . Authors from 帝京科学大学 広報担当, Kyushu University, 麻布大学（学校法人 麻布獣医学園）, Kawasaki Medical School, Kawasaki University of Medical Welfare and Kyowa Kirin
Co., Ltd.

α-Klotho is a longevity-related protein. Its deficiency shortens lifespan with prominent senescent phenotypes including muscle atrophy and weakness in mice. α-Klotho has two forms: membrane α-Klotho (m-α-Klotho) and circulating α-Klotho (c-α-Klotho). Loss of m-α-Klotho impairs a phosphaturic ...

09/02/2023

The Parkinson-associated toxin paraquat shifts physiological αS tetramers toward monomers that can be calpain-truncated and form oligomers

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The Parkinson-associated toxin paraquat shifts physiological αS tetramers toward monomers that can be calpain-truncated and form oligomers. Authors from the Ann Romney Center for Neurologic Diseases, Mass General Brigham.

Abnormal aggregation of α-synuclein (αS) is thought to initiate neuronal dysfunction and death in Parkinson’s disease (PD). In addition to higher molecular weight, oligomeric and polymeric forms of αS associated with neurotoxicity and disease, recent findings indicate the occurrence of physiolo...

09/02/2023

The American Journal of Pathology was saddened to learn of the passing of Associate Editor, Dr. Jouni Uitto. Dr. Uitto joined the editorial staff in 2008 and oversaw the peer review process for our manuscripts.

A tribute from AAD Member can be viewed online here: https://rb.gy/gz6io4

08/02/2023

Tensor Decomposition of Largest Convolutional Eigenvalues Reveals Pathological Predictive Power of RhoB in Re**al Cancer Biopsy

: Tensor Decomposition of Largest Convolutional Eigenvalues Reveals Pathological Predictive Power of RhoB in Biopsy. Authors from Prince Mohammad Bin Fahd University, Linköpings universitet and Sichuan Provincial People's Hospital.

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RhoB protein belongs to the Rho GTPase family, which plays an important role in governing cell signaling and tissue morphology. RhoB expression is known to have implications in pathological processes of diseases. Investigation in the regulation and communication of this protein detected by immunohis...

08/02/2023

Inhibition of Heat Shock Factor 1 Signaling Decreases Growth via Induction of Apoptosis. FREE Editor's Choice article from American Society for Investigative Pathology member Paul Monga and colleagues at Pitt School of Medicine: https://ajp.amjpathol.org/article/S0002-9440(22)00355-8/fulltext
[HSF-1 is elevated in tumors in a mouse model of hepatoblastoma.]

06/02/2023

TRPV1 dysfunction impairs gastric nitrergic neuromuscular relaxation in high fat diet induced diabetic gastroparesis mice.

: TRPV1 dysfunction impairs gastric nitrergic neuromuscular relaxation in high fat diet induced diabetic gastroparesis mice.

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Diabetic gastroparesis (DGP) is characterized by delayed gastric emptying of solid food without mechanical obstruction. Nitrergic neuron-mediated fundus relaxation and intragastric peristalsis are pivotal for gastric emptying and are impaired in patients with DGP. Transient receptor potential vanill...

03/02/2023

FUT8-AS1/miR-944/Fused in Sarcoma/Transcription Factor 4 Feedback Loop Participates in the Development of Oral Squamous Cell Carcinoma through Activation of Wnt/β-Catenin Signaling Pathway

"FUT8-AS1/miR-944/Fused in Sarcoma/Transcription Factor 4 Feedback Loop Participates in the Development of Oral through Activation of Wnt/β-Catenin Signaling Pathway", authors from The First Affiliated Hospital of Zhengzhou University.

Full text with excellent :

As a common type of head and neck squamous cell carcinoma, oral squamous cell carcinoma (OSCC) is a lethal and deforming disease. Long noncoding RNAs have emerged as critical modulators in different malignancies. However, the role of fucosyltransferase 8 antisense RNA 1 (FUT8-AS1) in OSCC still rema...

01/02/2023

Table of Contents page: The American Journal of Pathology

New month, new ! The February 2022 issue of The American Journal of Pathology is now fully free in the !

Full issue:

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01/02/2023

Identification of an Electrogenic 2Cl-/H+ Exchanger, ClC5, as a Chloride-Secreting Transporter Candidate in Kidney Cyst Epithelium in Tuberous Sclerosis. FREE Editor's Choice article from authors at New Mexico VA Health Care System, UNM Health Sciences, University of Florida, University of Tennessee Health Science Center, St. Jude Children's Research Hospital, and University of Cincinnati: https://ajp.amjpathol.org/article/S0002-9440(22)00356-X/fulltext. And don't miss the Insightful companion Commentary by Grazia Tamma at Università degli Studi di Bari Aldo Moro: https://ajp.amjpathol.org/article/S0002-9440(22)00390-X/fulltext.
[Expression of ClC5 and H+ ATPase in kidneys of Tsc2 KO mice]

31/01/2023

Coronavirus Disease 2019 (COVID-19) Coronary Vascular Thrombosis

: Coronavirus Disease 2019 () Coronary Vascular Thrombosis: Correlation with Neutrophil but Not Endothelial Activation. From American Society for Investigative Pathology member Dr. Jordan Pober and colleagues from Yale Medicine and Brigham and Women's Hospital.

Free in the :

Severe coronavirus disease 2019 (COVID-19) increases the risk of myocardial injury that contributes to mortality. This study used multiparameter immunofluorescence to extensively examine heart autopsy tissue of 7 patients who died of COVID-19 compared to 12 control specimens, with or without cardiov...

30/01/2023

Dr. Martha B. Furie has begun her second term as Editor-in-Chief of The American Journal of Pathology. We look forward to 5 more years of her leadership!

30/01/2023

Whole-Slide Cytometric Feature Mapping for Distinguishing Tumor Genomic Subtypes in Head and Neck Squamous Cell Carcinoma Whole-Slide Images

"Whole-Slide Cytometric Feature Mapping for Distinguishing Tumor Genomic Subtypes in Head and Neck Squamous Cell Carcinoma Whole-Slide Images", new from American Society for Investigative Pathology member Dr. Stephanie Blocker and colleagues from Duke Health.

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Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease where, in advanced stages, clinical and pathologic stages do not correlate with outcome. Molecular and genomic biomarkers for HNSCC classification have shown promise for prognostic and therapeutic applications. This study utili...

26/01/2023

New study suggests a promising therapeutic target for sepsis

New from The American Journal of Pathology and Elsevier: "New study suggests a promising therapeutic target for "

Promoting autophagy restores intestinal barrier function in sepsis, investigators report in The American Journal of Pathology

25/01/2023

Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease

"Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease"

New article: https://ajp.amjpathol.org/article/S0002-9440(22)00358-3/fulltext

Authors from Novartis, Gobierno de México, Friedrich Miescher Institute for Biomedical Research, Université de Lausanne, Humanitas University and Humanitas Hospitals - International.

The roof plate-specific spondin–leucine-rich repeat-containing G-protein coupled receptor 4/5 (LGR4/5)–zinc and ring finger 3 (ZNRF3)/ring finger protein 43 (RNF43) module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic zonation. However, its impact on nonalcoholic fatty ...