The American Journal of Pathology

07/09/2025

Effect of Fibroblast Signaling on Macrophage Polarization. From American Society for Investigative Pathology member author Dr. Cecelia Yates and colleagues from the Swanson School of Engineering, University of Pittsburgh School of Nursing, Pitt School of Medicine, University of Illinois Chicago, and the McGowan Institute for Regenerative Medicine.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00141-5/fulltext

07/09/2025

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07/08/2025

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07/08/2025

: Activin A Prevents Hyperresponsiveness to Vascular Endothelial Growth Factor in Pathologic Blood Vessels by Perturbing the Trafficking of Activated Vascular Endothelial Growth Factor Receptor 2.

From American Society for Investigative Pathology member author Dr. Andrius Kazlauskas and colleagues from University of Illinois Chicago

text:

Although quality-of-life compromising afflictions, such as diabetic retinopathy (DR), are driven by vascular endothelial growth factor (VEGF), there is a growing appreciation that the concentration of VEGF is not the only influencer of vascular dysfunction within the retina. Activin A (activin), a l...

07/08/2025

: Cryptochrome 2 Suppresses Epithelial-Mesenchymal Transition by Promoting Trophoblastic in Unexplained Recurrent Spontaneous Abortion.

Free in the : https://ajp.amjpathol.org/article/S0002-9440(24)00114-7/abstract

07/07/2025

: DNA Methylation Dynamics in a Mouse Model of Retinitis Pigmentosa. From American Society for Investigative Pathology member D**g Feng Chen and colleagues from Massachusetts Eye and Ear.

Full text:

Retinitis pigmentosa (RP) is a group of sight-threatening genetic diseases characterized by progressive degeneration of photoreceptors, leading to severe vision loss from childhood to adulthood. With limited treatment options, understanding the molecular mechanisms underlying RP is crucial. Evidence...

07/07/2025

Involvement of heat shock protein 47 in osteophyte formation of knee joint osteoarthritis. From American Society for Investigative Pathology member author Dr. Yasunori Okada and colleagues from 順天堂/Juntendo Univ

text:

Osteophytes contribute to the development and progression of knee osteoarthritis (OA). Although transforming growth factor-β (TGF-β) and bone morphogenic protein-2 (BMP2) are known to induce osteophytes, regulators of osteophyte formation remain elusive. This study aimed to search for molecules th...

07/07/2025

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07/05/2025

: A -based assessment pipeline for intraepithelial and stromal tumor-infiltrating lymphocytes in high-grade serous ovarian carcinoma. Authors from Kyoto University Graduate School of Medicine, Kindai University,

Free in the :

Tumor-infiltrating lymphocytes (TILs) are associated with improved survival in patients with epithelial ovarian cancer. However, TIL evaluation has not been used in routine clinical practice because of reproducibility issues. The current study developed two convolutional neural network models to det...

07/04/2025

: Interleukin-6 Trans Signaling Regulates Neutrophilic Inflammation in Alcohol-Associated Hepatitis. Authors from UC Davis School of Medicine, Universidad de Navarra, Yale School of Medicine, Mayo Clinic and IDIBAPS

text:

Alcohol-associated hepatitis (AH) is a form of acute on chronic liver failure characterized by intrahepatic neutrophilic inflammation. In hepatocytes, IL-6 can signal through membrane-bound (classical signaling) or soluble (trans signaling) IL-6 receptors to regulate liver injury responses. The goal...

07/04/2025

Leucine-rich repeat kinase 2 promotes disintegration of retinal pigment epithelial cell: Implication in the pathogenesis of dry age-related macular degeneration. From American Society for Investigative Pathology member author Dr. Miyuki Murata and colleagues from Hokkaido University.

text:

Recent epidemiologic studies have shown that patients with age-related macular degeneration (AMD) have a considerably higher risk of developing Parkinson disease (PD) later in life, suggesting a possible link between these diseases. However, the common mechanisms between these two diseases remain ob...

07/03/2025

: Tumor Necrosis Factor Receptor-2 Signals Clear-Cell Renal Carcinoma Proliferation via Phosphorylated 4E Binding Protein-1 and Mitochondrial Gene Translation. From American Society for Investigative Pathology members Dr. Rafia Al-Lamki and Dr. Jordan Pober with colleagues from University of Cambridge and Yale University.

text:

Clear-cell renal cell carcinoma (ccRCC), a tubular epithelial malignancy, secretes tumor necrosis factor (TNF), which signals ccRCC cells in an autocrine manner via two cell surface receptors, TNFR1 and TNFR2, to activate shared and distinct signaling pathways. Selective ligation of TNFR2 was shown....