NEJM Clinician

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NEJM Clinician is a new digital resource designed to help physicians quickly and efficiently stay informed of the latest clinical advances with curated, summarized and contextualized clinical research and guidelines, along with NEJM content.

𝙂π™ͺπ™žπ™™π™šπ™‘π™žπ™£π™š π™’π™–π™©π™˜π™: Updated consensus guidance from the Infectious Diseases Society of America (IDSA) on the treatment of a...
09/15/2026

𝙂π™ͺπ™žπ™™π™šπ™‘π™žπ™£π™š π™’π™–π™©π™˜π™: Updated consensus guidance from the Infectious Diseases Society of America (IDSA) on the treatment of antimicrobial-resistant gram-negative infections incorporates several newly approved agents.

"The new recommendation reinforces my practice: In patients with severe S. maltophilia infection, I typically avoid trimethoprim–sulfamethoxazole and instead choose cefiderocol, aztreonam–avibactam, or a new-generation tetracycline," writes George Sakoulas, MD.

Download the Guideline Watch Roundup for summaries and highlights of the most important new clinical guidelines to infor...
09/15/2026

Download the Guideline Watch Roundup for summaries and highlights of the most important new clinical guidelines to inform your practice. πŸ‘‰ https://jwat.ch/46iwXPT

Excessive crying in infancy is common, but an underlying medical cause is rarely identified during the first year. A ret...
09/15/2026

Excessive crying in infancy is common, but an underlying medical cause is rarely identified during the first year. A retrospective study of colicky infants looked at whether longer follow-up might uncover additional diagnoses.

"These data support our current approach of reassuring parents, as most infants had no underlying condition identified. However, the findings also remind us that some diagnoses emerge months later, so if a child’s crying persists, I would consider the possibility of cow’s milk allergy or a congenital disease," writes Clement D. Lee, MD, MSc.

09/14/2026

Should your patients with cirrhosis but no varices be on a beta-blocker? Deputy Editor Rahul B. Ganatra, MD, MPH, weighs in.

𝙂π™ͺπ™žπ™™π™šπ™‘π™žπ™£π™š π™’π™–π™©π™˜π™: Updated AAP guidelines on iron deficiency prevention and management expand how and when we should scree...
09/13/2026

𝙂π™ͺπ™žπ™™π™šπ™‘π™žπ™£π™š π™’π™–π™©π™˜π™: Updated AAP guidelines on iron deficiency prevention and management expand how and when we should screen children and adolescents to increase early detection.

"To me, the bigger practice change may be learning to think about iron deficiency before anemia develops," writes Deputy Editor Ann Cheung, MD, MBA, MS.

For patients with complicated UTIs caused by extended-spectrum Ξ²-lactamase (ESBL)–producing Enterobacterales, oral nonca...
09/12/2026

For patients with complicated UTIs caused by extended-spectrum Ξ²-lactamase (ESBL)–producing Enterobacterales, oral noncarbapenem options are needed. A new trial evaluated step-down to oral fosfomycin versus continued IV treatment.

A new study provides reassurance that selected patients with gram-positive bacteremia can safely transition from IV to o...
09/11/2026

A new study provides reassurance that selected patients with gram-positive bacteremia can safely transition from IV to oral therapy after initial stabilization.

"Choosing the right timing and agent for this transition can be nuanced, so I’d involve infectious disease colleagues when possible," writes Kathleen Finn, MD, MPhil, SFHM.

Guideline Watch Roundup: A collection of 12 clinical guideline summaries that will impact how you practice medicine. Dow...
09/10/2026

Guideline Watch Roundup: A collection of 12 clinical guideline summaries that will impact how you practice medicine. Download now to discover 12 new and updated guideline summaries to help you stay informed and confident in your practice: https://jwat.ch/46iwXPT

𝙂π™ͺπ™žπ™™π™šπ™‘π™žπ™£π™š π™’π™–π™©π™˜π™: The American Gastroenterological Association (AGA) provides guidance (based on expert opinion) on manag...
09/10/2026

𝙂π™ͺπ™žπ™™π™šπ™‘π™žπ™£π™š π™’π™–π™©π™˜π™: The American Gastroenterological Association (AGA) provides guidance (based on expert opinion) on management of 𝘊𝘭𝘰𝘴𝘡𝘳π˜ͺπ˜₯π˜ͺ𝘰π˜ͺπ˜₯𝘦𝘴 π˜₯π˜ͺ𝘧𝘧π˜ͺ𝘀π˜ͺ𝘭𝘦 infection in adults.

This AGA expert review highlights "the efficacy of microbiome-based therapies for preventing recurrent CDI and will prompt me to refer patients for these effective therapies after a first or second recurrence."

MMR vaccination was not associated with increased autism risk in a large cohort study that employed robust methods to mi...
09/09/2026

MMR vaccination was not associated with increased autism risk in a large cohort study that employed robust methods to minimize bias and confounding.

"Misinformation about MMR vaccine leads to vaccine delay or avoidance, which places children β€” and the greater community β€” at risk," writes Deborah Lehman, MD.

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