NEJM Journal Watch

NEJM Journal Watch Over 100 physician-editors regularly survey more than 250 medical journals and deliver only the most important clinical research findings.
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11/14/2025

Catch up on Kidney Week 2025 with Dr. Meghan Sise and Dr. Daniel Edmonston as they discuss the highlights and themes of the meeting with Dr. Jaye Hefner. https://jwat.ch/4qWN26V

In a study of patients who received immune checkpoint inhibitor (ICI) therapy for cancer, researchers compared outcomes ...
11/14/2025

In a study of patients who received immune checkpoint inhibitor (ICI) therapy for cancer, researchers compared outcomes among patients who received the COVID-19 mRNA vaccines within 100 days of starting ICI therapy and those who didn't. https://jwat.ch/43rQOuS

A meta-analysis strongly supports the use of GLP-1 and dual GIP/GLP-1 RAs for treatment of intracranial hypertension. ht...
11/13/2025

A meta-analysis strongly supports the use of GLP-1 and dual GIP/GLP-1 RAs for treatment of intracranial hypertension. https://jwat.ch/4hTQqey

More Evidence That Shingles Vaccine Lowers Risk for DementiaA large observational study showed that this vaccine benefit...
11/13/2025

More Evidence That Shingles Vaccine Lowers Risk for Dementia

A large observational study showed that this vaccine benefitted recipients beyond just protection against shingles. https://jwat.ch/4hWgpSQ

In September, the FDA approved remibrutinib (Rhapsido) for the treatment of chronic spontaneous urticaria in adults who ...
11/12/2025

In September, the FDA approved remibrutinib (Rhapsido) for the treatment of chronic spontaneous urticaria in adults who remain symptomatic despite H1-antihistamine treatment. https://jwat.ch/47QIpma

A New First-Line Standard for EGFR-Mutated NSCLC?First-line treatment of patients with EGFR-mutated NSCLC with osimertin...
11/11/2025

A New First-Line Standard for EGFR-Mutated NSCLC?

First-line treatment of patients with EGFR-mutated NSCLC with osimertinib and platinum-pemetrexed chemotherapy leads to significantly longer overall survival than osimertinib alone. https://jwat.ch/3Lp6c5d

Dr. Paul Sax recently asked ID fellows at Johns Hopkins a simple question: "What are your favorite ID consults?" Read th...
11/11/2025

Dr. Paul Sax recently asked ID fellows at Johns Hopkins a simple question: "What are your favorite ID consults?" Read their answers, and Dr. Sax's thoughts on what excites trainees most, in the latest HIV and ID Observations. https://jwat.ch/4qT4WYe

NEJM Group's latest coverage of Kidney Week:🔴 IgA nephropathy and sibeprenlimab🔴 Finerenone vs. spironolactone in CKD🔴 R...
11/10/2025

NEJM Group's latest coverage of Kidney Week:
🔴 IgA nephropathy and sibeprenlimab
🔴 Finerenone vs. spironolactone in CKD
🔴 Rising use of central venous catheters for initiating chronic hemodialysis
https://jwat.ch/3WKqAjF

Researchers in a landmark prostate cancer screening trial recently published long-term outcomes. Dr. Allan Brett comment...
11/10/2025

Researchers in a landmark prostate cancer screening trial recently published long-term outcomes. Dr. Allan Brett comments on the findings: https://jwat.ch/3LhO8Ke

Dr. Allan Brett discusses the FDA approval of oral semaglutide (Rybelsus) for secondary cardiovascular prevention in hig...
11/09/2025

Dr. Allan Brett discusses the FDA approval of oral semaglutide (Rybelsus) for secondary cardiovascular prevention in high-risk adults with type 2 diabetes — and an important caveat about the pivotal trial that led to this approval. https://jwat.ch/3LjI6c2

Cefiderocol in Health Care–Associated Gram-Negative BacteremiaMortality was overall similar to that seen with standard t...
11/08/2025

Cefiderocol in Health Care–Associated Gram-Negative Bacteremia

Mortality was overall similar to that seen with standard therapy but appeared worse in certain subsets of patients. https://jwat.ch/47tpKOl

NEJM Group is covering clinically important research from the American Society of Nephrology’s Kidney Week. In our first...
11/07/2025

NEJM Group is covering clinically important research from the American Society of Nephrology’s Kidney Week. In our first update:
- Treatments for IgA nephropathy
- Tumor lysis syndrome
- Prevention of kidney injury during cardiac surgery
https://jwat.ch/3JR3GEa

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