09/19/2026
The uterus may do far more than support pregnancy — it could also play a role in memory.
For decades, the nonpregnant uterus was often viewed mainly as a reproductive organ. But an intriguing animal study from Arizona State University suggests its influence may extend to the brain.
Researchers studied female rats that underwent hysterectomy while their ovaries were left intact. The animals later showed specific difficulties with spatial working memory, particularly as memory tasks became more demanding.
Interestingly, the surgery also altered some hormone patterns, despite the ovaries remaining in place.
The findings suggest that reproductive biology may involve a more interconnected uterus–ovary–brain system than previously appreciated. However, this research was conducted in rats, so it does not prove that hysterectomy causes memory problems in humans.
That distinction is important. Hysterectomy is one of the most common gynecological surgeries, and many patients retain their ovaries. Understanding whether removing the uterus alone has neurological or hormonal consequences could help researchers better investigate women's long-term brain health.
Source: Koebele, S. V. et al. Hysterectomy Uniquely Impacts Spatial Memory in a Rat Model: A Role for the Nonpregnant Uterus in Cognitive Processes. Endocrinology, 160(1), 1–16.