07/24/2025
Do your children have access to Kratom?
Kratom is a drug that can cause addiction.
It's effects are known to be those of other opioids and co***ne.
Article is followed below by a straightforward video explaining what Kratom is and its dangers.
Available in some local gas stations by the candy.
https://youtu.be/-SwFLCg17iM?si=tShFZf03xOEa4Zhi
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"Mitragynine and 7-hydroxymitragynine: key compounds in kratom
Mitragynine (MG) and 7-hydroxymitragynine (7-OH-MG or 7-OH) are the primary active ingredients in kratom (Mitragyna speciosa), a tropical tree native to Southeast Asia.
Key differences and roles
Mitragynine (MG) is the most abundant alkaloid in kratom leaves, making up approximately 2% of the leaf mass and up to two-thirds of the total alkaloid content. It has a complex pharmacology with low affinity and is reported as an antagonist at human μ-opioid receptors (in vitro), while acting as a partial agonist in animals, according to ScienceDirect.com. MG is also known to interact with other receptors in the brain, including those involved in the adrenergic, serotonergic, and dopaminergic systems. Studies have shown that MG can have various effects, such as analgesic, anti-inflammatory, and muscle relaxant properties.
7-Hydroxymitragynine (7-OH-MG) is present in much smaller amounts than MG in kratom leaves, typically accounting for less than 0.02% of the dry leaf mass. It is formed when the body metabolizes mitragynine. 7-OH-MG is significantly more potent than MG at the μ-opioid receptor, the main target for opioids like morphine, notes the FDA. In fact, it is reportedly 13 times more potent than morphine itself. Studies in mice indicate that 7-OH-MG is the main mediator of kratom's pain-relieving effects.
Potential addiction and abuse
Both MG and 7-OH-MG interact with μ-opioid receptors, which raises concerns about the potential for abuse and addiction.
Animal studies have yielded mixed results regarding the abuse potential of these compounds, according to NIDA.
Some research suggests that 7-OH-MG may have a higher addiction potential than MG.
Safety and regulatory concerns
The FDA has expressed serious concerns about the safety and potential for abuse linked to kratom products.
In 2016, the Drug Enforcement Administration considered classifying mitragynine and 7-hydroxymitragynine as Schedule I controlled substances but withdrew the notice following public feedback and requests for further research, according to Congress.gov.
While not federally scheduled, several states have taken action to ban or regulate kratom, including Alabama, Arkansas, Indiana, Rhode Island, Vermont, and Wisconsin, notes AppleGate Recovery.
The FDA has issued warnings about potential adverse events associated with kratom use, including liver toxicity, seizures, and substance use disorder.
There are also concerns about adulteration and contamination in kratom products, including with heavy metals and harmful bacteria.
Research and future outlook
Research on kratom and its alkaloids is still in its early stages.
More studies are needed to fully understand their effects, safety profile, and potential therapeutic uses.
The FDA supports research efforts by academic institutions, drug companies, and government agencies to gather more information on kratom.
NIDA is particularly interested in researching the potential of kratom and related compounds for treating chronic pain and opioid use disorder.
In summary, mitragynine and 7-hydroxymitragynine are the primary psychoactive compounds in kratom, with 7-OH-MG being the more potent and likely the main contributor to its opioid-like effects. However, concerns remain regarding their safety, potential for addiction, and the lack of robust scientific evidence to support their use for any medical purpose."
From the National Institute on Drug Addiction :https://www.drugabuse.gov/publications/drugfacts/kratom"Kratom can cause effects similar to both opioids and s...
