Practical Neurology

11/29/2025

An individual with progressive gait, cognitive, and cranial nerve symptoms had imaging consistent with intracranial hypotension, but repeated CTM/DSM found no leak. A fractured implant was identified as the cause in a case report by Drs. Kushwah, Tiwari, Chhabra, Bhalla, Bhaskar, and Panda.
https://ow.ly/vr1W50Xyrur
AIIMS Jodhpur American Academy of Neurology (AAN) American Association of Neurological Surgeons CSF Leak Association - The Cerebrospinal Fluid Leak Charity

11/28/2025

The U.S. Food and Drug Administrationhas approved (Novartis) for people aged ≥2 years with and an SMN1 mutation—expanding gene-replacement therapy options for .
https://ow.ly/TGlJ50XyrFQ
Cure SMA SMA News Today American Academy of Neurology (AAN) Child Neurology Society

The Food and Drug Administration has approved Itvisma (onasemnogene abeparvovec-brve; Novartis, Basel, Switzerland) for the treatment of people aged 2 yea…

11/27/2025

Once-daily + therapy reduced risk vs placebo with no rise in ISTH major bleeding in people with noncardioembolic ischemic stroke or high-risk TIA.
https://ow.ly/UpUO50Xyr7Z
American Heart Association Endovascular Today

For people with noncardioembolic ischemic stroke or high-risk transient ischemic attack (TIA), once-daily treatment with asundexian (Bayer, Berlin, German…

11/26/2025

Strategies for managing drug-resistant are expanding with advances in less-invasive surgery—innovations in , laser ablation, and are broadening candidacy. Drs. Gallagher and Fallah review these technologies and their applications: https://ow.ly/JP2b50XypG6
American Epilepsy Society American Academy of Neurology (AAN) American Association of Neurological Surgeons UCLA David Geffen School of Medicine at UCLA

11/26/2025

Updated consensus guidelines for the use of peripheral nerve stimulation in chronic and certain indications have been published by the American Society of Pain & Neuroscience.
https://ow.ly/Kkz450XxRL9
American Academy of Neurology (AAN)

A multidisciplinary expert panel convened by the American Society of Pain and Neuroscience has released updated consensus guidelines on the use of periphe…

11/24/2025

Treatment with ( ; ) was shown to significantly reduce monthly days vs placebo in adults with chronic migraine, according to data published in .
https://ow.ly/Ww0A50Xw4sT
American Headache Society® American Migraine Foundation American Academy of Neurology (AAN)

Treatment with Vyepti (eptinezumab-jjmr; Lundbeck, Copenhagen, Denmark) was shown to significantly reduce monthly migraine days (MMDs) compared with place…

11/24/2025

plays a key role in refractory/super-refractory status . Drs. Silverman, Nagesh, Ho, and Santoro outline the current understanding of immunotherapeutic and agents for the management of RSE.
https://ow.ly/zy8w50Xw335
American Epilepsy Society American Academy of Neurology (AAN) Keck School of Medicine of USC

The role of neuroinflammation in refractory and superrefractory status epilepticus, as well as the role of therapeutic immunomodulation in their managemen…

11/23/2025

The U.S. Food and Drug Administration has granted 510(k) clearance to 2 devices developed by Vesalio for use in peripheral and neurovascular aspiration.
https://ow.ly/44Jy50XuWy4
Endovascular Today American Academy of Neurology (AAN) Stroke Organization

The Food and Drug Administration (FDA) has granted 510(k) clearance to 2 devices developed by Vesalio (Plano, TX) designed to be used for aspiration durin…

11/22/2025

For treatment, isoform-selective sodium channel inhibitors that spare GABAergic interneuron function are an exciting area of research. Dr. Raman Sankar reviews emerging selective sodium channel antagonists in a new article: https://ow.ly/hcQ450XvYlt
American Epilepsy Society American Academy of Neurology (AAN) UCLA American Academy of Neurology (AAN) David Geffen School of Medicine at UCLA

11/21/2025

For people with long- , treatment with for 26 days was not shown to improve functional capacity, respiratory measures, inflammatory markers, or patient-reported outcomes. Data published in JAMA Internal Medicine.
https://ow.ly/EuOJ50XuUY1
American Academy of Neurology (AAN) American Medical Association

Treatment with colchicine for 26 days was not shown to improve functional capacity, respiratory measures, inflammatory markers, or patient-reported outcom…

11/20/2025

Adding to standard -C–lowering therapy for people with or but no previous infarction or was shown to reduce risk for first major event.
https://ow.ly/yggJ50XuUmK
American Heart Association Endovascular Today American Academy of Neurology (AAN)

The addition of the proprotein convertase subtilisin/Kexin type 9 (PCSK9) enzyme inhibitor Repatha (evolocomab; Amgen, Thousand Oaks, CA) to standard low-…

11/20/2025

What should you tell patients about and ? Learn about the 3 main axis pathways for microplastics, what is currently known about the effects of those plastics on the CNS, and what you can do to protect yourself in a new Special Report: https://ow.ly/pNtn50XuUqy
American Academy of Neurology (AAN) Donald and Barbara Zucker School of Medicine at Hofstra/Northwell University of Miami American College of Occupational and Environmental Medicine American Medical Association

Microplastics and "Negative Neuroplasticity"