A monthly publication that strives to enhance quality of care and improve the daily operation of neurology practices. Each month, our experts explain the real-world significance of recent advances in neurologic science and offer step-by-step advice on how to overcome the clinical and business challenges neurologists face.
Our straightforward, how-to articles give neurologists tools they can put into practice right away.
Operating as usual
Bruton Tyrosine Kinase Inhibition in Multiple Sclerosis #neurology #MS #PracticalNeurology https://hubs.ly/Q014Hl1N0
The missing link for treatment optimization?
Ischemic Stroke Has Better Outcomes at Comprehensive and Thrombectomy-Capable Stroke Centers #stroke #neurology #PracticalNeurology https://hubs.ly/Q014d8pl0
Individuals with ischemic strokes were more likely to be discharged home or to rehabilitation centers after they received care at Comprehensive Stroke
Case Report: Hyperekplexia & Encephalopathy #neurology #brain #PracticalNeurology https://hubs.ly/Q013WZ5H0
A novel glycine receptor Β (GLRB) variant was identified in 2 unrelated children of Puerto Rican descent who both had hyperekplexia and encephalopathy.
New Balloon Guide Catheter for Acute Ischemic Stroke Treatment #stroke #neurology #PracticalNeurology https://hubs.ly/Q013L68F0
A next generation balloon guide catheter (Emboguard; CERENOVUS, Irvine, CA) to be used in endovascular procedures for individuals with acute isc
#Zilucoplan Improved Activities of Daily Living for Individuals with Myasthenia Gravis #gMG #ALS #PracticalNeurology https://hubs.ly/Q013Grg-0
The phase 3 clinical trial, RAISE (NCT04115293) of subcutaneous zilucoplan (RA101495; UCB, Atlanta, GA) demonstrated improvement in activities of dail
#Blarcamesine Reduces Rett Syndrome Symptoms #neurology #rettsyndrome #PracticalNeurology https://hubs.ly/Q013vcLy0
Blarcamesine (Anavex2-73; Anavex Life Sciences Corp, New York, NY), once daily oral liquid doses of up to 30mg, demonstrated statistically significant
Antiplatelet Therapies After Ischemic Stroke #stroke #brain #PracticalNeurology https://hubs.ly/Q013mVq30
Antiplatelet therapies are effective for prevention of secondary stroke and can be tailored to individual patient needs.
A Synthetic Derivative of Squalamine Restored the Function of Enteric Nerve Cells in Parkinson Disease #neurology #PD #PracticalNeurology https://hubs.ly/Q013j67-0
In the phase 2b KARMET study, participants (n=150) with Parkinson disese (PD) and constipation treated with a synthetic derivative of squalamine (ENT-
US_FDA Grants Priority Review to #Risdiplam for Spinal Muscular Atrophy Treatment in Presymptomatic Infants Under Age 2 Months #SMA #neurology #childneurology #PracticalNeurology https://hubs.ly/Q0134v4k0
The Food and Drug Administration (FDA) granted priority review of a supplemental new drug application (sNDA) for the use of risdiplam (Evrysdi; PTC Th
#Vutrisiran Efficacy for hATTR Amyloidosis with Polyneuropathy Maintained After 18 Months of Treatment #neurology #PracticalNeurology https://hubs.ly/Q012WcCj0
The phase 3 HELIOS-A study (NCT03759379) of vutrisiran (Alnylam Pharmaceuticals, Cambridge, MA) showed efficacy and safety at 9 months and continued t
FDA Approves #Daridorexant for Insomnia #neurology #sleep
#insomnia #PracticalNeurology https://hubs.ly/Q0120ljL0
The Food and Drug Administration (FDA) approved daridorexant (Quviviq; Idorsia, Radnor, PA) for insomnia treatment. In the phase 3 clinical program, d
Cardiovascular Risks in Middle Age May Be Worse for Cognition in Women #women #brain #neurology #PracticalNeurology https://hubs.ly/Q011JFwk0
As published by Neurology, cardiovascular conditions in women are more associated with a negative impact on thinking and memory abilities compared wit
First Participant Dosed of Novel Chimeric Cell Therapy for Duchenne Muscular Dystrophy #neurology #brain #DMD #PracticalNeurology https://hubs.ly/Q011yMZn0
The first patient has been treated in a phase 1 clinical study of dystrophin-expressing chimeric cells (DEC)(DT-DEC01; Dystrogen Therapeutics, Miami,
Utilizing Real-World Data to Examine Outcomes in Patients With Amyotrophic Lateral Sclerosis #ALS #neurology #PracticalNeurology https://hubs.ly/Q011qXyY0
It is well established that randomized clinical trials (RCTs) are the gold standard for effectiveness and safety in clinical research.1 In amyotrop
Price of Aducanumab Treatment for Early Alzheimer Disease Cut in Half - Practical Neurology https://hubs.ly/Q0110CPl0 Biogen #AD #Alzheimer Disease
The price of the first potentially disease-modifying treatment for Alzheimer disease (AD), aducanumab (Aduhelm; Biogen, Cambridge, MA and Eisai, Woodc
BREAKING NEWS: FDA approves new treatment for generalized #myastheniagravis https://hubs.ly/Q0110DsR0 #gMG #ArgenxGlobal #FDA
The Food and Drug Administration (FDA) has approved efgartigimod (Vyvgart; Argenx, Boston, MA) for treatment of generalized myasthenia gravis (gMG) in
Global Ischemic Stroke Mortality Rate Lowered Over Last 30 years #neurology #stroke #brain #PracticalNeurology https://hubs.ly/Q010-8j40
As published in Neurology, the mortality rates for stroke decreased slightly from 1990 to 2019 worldwide. However, the number of individuals who died
#Suvecaltimide for Essential Tremors Clinical Trial Enrolls First Participant #neurology #brain #essentialtremors #PracticalNeurology https://hubs.ly/Q010XN7n0
The first participant has been enrolled in the phase 2b clinical trial (NCT05122650) of suvecaltamide (JZP385; Jazz Pharmaceuticals, Philadelphia
Combination Extended Release Pramipexole/Rasagiline Effective for Parkinson Disease #neurology #brain #PD #Pramipexole #Rasagiline #PracticalNeurology https://hubs.ly/Q010WbX_0
In a phase 3 study (NCT03329508), a combination therapy of pramipexole/rasagiline (P2B001; Pharma Two B, Rehovot, Israel) was superior compared with e
#Pitolisant Post Hoc Analysis Shows Rapid Onset of Response for #Narcolepsy Symptoms - #neurology #PracticalNeurology https://hubs.ly/Q010NjHG0
As published in CNS Drugs, post hoc analysis of clinical trial data shows a 2- to 3-week time to onset of response to pitolisant (Wakix; Harmony Biosc
#Rozanolixizumab Improves in Activities of Daily Living in Individuals with Generalized Myasthenia Gravis #neurology #gMG #brain #PracticalNeurology https://hubs.ly/Q010LdZq0
In the phase 3 MycarinG study1 (NCT03971422), adults with generalized myasthenia gravis (gMG) treated with 1 of 2 doses of rozanolixizumab (UCB7665; C
#Trofinitide Treatment of #RettSyndrome Provides Clinician- and Caregiver-Rated Improvement #neurology #brain #PracticalNeurology https://hubs.ly/Q010zM520
A phase 3 study that evaluated the efficacy and safety of the investigational drug achieved positive topline results. The 12-week, placebo-controlled
World Federation of Neurology Emphasizes Importance in Brain Health Initiative Program #neurology #brain #brainhealthinitiative #PracticalNeurology https://hubs.ly/Q010kGph0
The World Federation of Neurology (WFN) has launched the Brain Health Initiative (BHI), a new program to enable major organizations, institution
Disability Improvement and Possible Remyelination in Progressive Multiple Sclerosis After Novel T-Cell Treatment Targeting Latent Epstein-Barr Virus #brain #MS #neurology #PracticalNeurology https://hubs.ly/Q010fYBW0
Treatment with allogeneic T cells, targeting B cells and plasma cells containing Epstein-Barr virus (ATA188; Atara, South San Francisco, CA), resulted
US_FDA Accepts Priority Review Application for #Fenfluramine for #Lennox-Gastaut Seizures #seizure #neurology #PracticalNeurology https://hubs.ly/Q0106CN60
The Food and Drug Administration (FDA) has accepted for filing and granted priority review to a supplemental New Drug Application (sNDA) for the use o
Phase 3 Study of #Tolperisone for Muscle Spasms Completes Enrollment #neurology #musclespams #PracticalNeurology https://hubs.ly/Q01018bm0
Enrollment of 1,000 participants is complete for the phase 3 RESUME-1 study (NCT04671082) of tolperisone (Mydocalm; Neurana Pharmaceuticals, San Diego
Melissa Hagan, PhD, MPH from Mitsubishi Tanabe Pharma America, Inc. discusses Utilizing Real-World Data to Examine Outcomes in Patients with Amyotrophic Lateral Sclerosis #ALS #RWD #RCT https://practicalneurology.com/articles/2021-nov-dec/utilizing-real-world-data-to-examine-outcomes-in-patients-with-amyotrophic-lateral-sclerosis?c4src=home:feed
It is well established that randomized clinical trials (RCTs) are the gold standard for effectiveness and safety in clinical research.1 In amyotrop
Oral Solution of #Celecoxib Becoming Available for Acute Migraine Treatment #PracticalNeurology #neurology #migraine https://hubs.ly/H0_Z6Mc0
Oral celecoxib (Elyxyb; BioDelivery Sciences International, Raleigh, NC and Dr. Reddy's Laboratories, Hyderabad, India) is a ready-to-use oral sol
Advances in Preventive Treatment of Migraine Continue #migraine #neurology #PracticalNeurology https://hubs.ly/H0_C0Kv0
At the Scottsdale Headache Symposium, the latest pharmacologic treatments for prevention of episodic migraine were reviewed. The focus remained on pha
Risk Factors and Management Strategies for Posttraumatic Headaches #neurology #brain #headache #PracticalNeurology https://hubs.ly/H0_yrzX0
Headaches after head trauma are frequent with many potential pathophysiologic pathways including neuroinflammation, impaired descending neuromodulatio
Advances in Preventive Treatment of Migraine Continue #migraine #headache #neurology #PracticalNeurology https://hubs.ly/H0_yr6Z0
At the Scottsdale Headache Symposium, the latest pharmacologic treatments for prevention of episodic migraine were reviewed. The focus remained on pha
American Academy of Neurology Publishes New Parkinson Disease Guideline #neurology #PD #PracticalNeurology https://hubs.ly/H0_wXH20
The American Academy of Neurology (AAN) has issued an updated guideline that provides recommendations for treating motor symptoms in people with
Genentech recently hosted a panel where leading Alzheimer’s disease (AD) experts discussed the biggest questions in the space and how to address key challenges. Tell us what you think is the most urgent challenge in AD. Take our poll here: https://twitter.com/PracticalNeuro/status/1460984349801730063
“@Genentech recently hosted a panel where leading #AlzheimersDisease (AD) experts discussed the biggest questions in the space. Below are some of the topics that came up. Take the poll and tell us what you think is one of the most urgent challenges in #AD. #sponsored”
Repurposing Approved Drugs #Riluzole, #Rotigotine, and #Levetiracetam for Potential Treatment of Alzheimer Disease #neurology #brain #AD #PracticalNeurology https://hubs.ly/H0_1K1x0
During a symposium at the Clinical Trials in Alzheimer Disease Conference, held in Boston, MA November 9-12, repurposing of 3 previously approved drug
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