11/05/2024
The novel ion-exchange chromatography (IEC) method developed for exosome separation demonstrated significant advantages in terms of yield, purity, and biological effects when compared to traditional ultracentrifugation. The lower protein contamination and better particle dispersion achieved with IEC, along with its superior clonogenic and healing effects on lung epithelial cells, suggest that IEC can play a crucial role in future exosome separation strategies, particularly for large-scale applications.
Copyrights: Wei-yuan Zhang, Xiaochen Cheng, Li Wen, Li Du, Yuxin Lu, Li-Sheng Wang, Feng-Jun Xiao, 2024. License: This work is licensed under a Creative Commons Attribution 4.0 International License.