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22/08/2025

🔬 Exploring the Genetics Behind Knee Function

The review “Genomic Determinants of Knee Joint Biomechanics: An Exploration into the Molecular Basis of Locomotor Function” by Georgian-Longin Iacobescu et al., published in Current Issues in Molecular Biology, uncovers how genetics shape knee biomechanics.

From collagen genes like COL1A1 and COL5A1 influencing ligament strength to genetic insights into osteoarthritis, this work highlights the potential for personalized rehabilitation and regenerative strategies.

A must-read for researchers in orthopedics, genomics, and personalized medicine!

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In recent years, the nexus between genetics and biomechanics has garnered significant attention, elucidating the role of genomic determinants in shaping the biomechanical attributes of human joints, specifically the knee. This review seeks to provide a comprehensive exploration of the molecular basi...

22/08/2025

🔬 Highly Cited & Viewed Article!

📖 “Updates on the Activity, Efficacy and Emerging Mechanisms of Resistance to Cefiderocol”
by Gabriele Bianco, Matteo Boattini, Monica Cricca, Lucia Diella, Milo Gatti, Luca Rossi, Michele Bartoletti, Vittorio Sambri, Caterina Signoretto, Rossella Fonnesu, Sara Comini, and Paolo Gaibani.

Published in Current Issues in Molecular Biology, this comprehensive review explores:
✅ Cefiderocol’s unique “Trojan horse” mechanism of action
✅ Its broad antibacterial activity and clinical efficacy against MDR Gram-negative bacilli
✅ Emerging mechanisms of resistance reshaping its clinical role
✅ Future strategies to preserve its therapeutic potential

This article has already gained significant attention from the research community, highlighting its impact in the field of antimicrobial resistance and precision therapy.

📌 Read the full paper here:

In recent years, novel antimicrobials have been developed to counter the emergence of antimicrobial resistance and provide effective therapeutic options against multidrug-resistant (MDR) Gram-negative bacilli (GNB). Cefiderocol, a siderophore cephalosporin, represents a novel valuable antimicrobial....

21/08/2025

📌 Highly Cited & Viewed in Current Issues in Molecular Biology

"A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer"
by Andreea-Adriana Neamțu, Teodor Andrei Maghiar, Violeta Turcuș, Paula Bianca Maghiar, Anca-Maria Căpraru, Bianca-Andreea Lazar, Cristina-Adriana Dehelean, Ovidiu Laurean Pop, Carmen Neamțu, Bogdan Dan Totolici, and Endre Mathe.

🔗 Read the article here https://brnw.ch/21wV5sF

☕ Chlorogenic acids, naturally abundant in coffee and other plant-based foods, are gaining attention for their anticancer potential.
This review highlights their role in colorectal cancer prevention and therapy, with key mechanisms including:
✔️ Cell cycle arrest
✔️ Apoptosis induction
✔️ Modulation of Wnt, PI3K/Akt, and MAPK signaling
✔️ Regulation of inflammatory mediators

With colorectal cancer incidence still on the rise, chlorogenic acids represent a promising link between diet, metabolism, and cancer prevention.

📖 Published in the Special Issue: Molecular Research in Bioactivity of Natural Products.

Chlorogenic acids are plant secondary metabolites, chemically—polyphenols with similar biological activity, formed through the esterification of quinic acid and hydrocinnamic acid moieties. They are best known for their high concentration in coffee and other dietary sources and the antioxidant pro...

21/08/2025

📌 Highly Cited in Current Issues in Molecular Biology

"Capsaicin: Emerging Pharmacological and Therapeutic Insights"
by Elena Madalina Petran, Argyrios Periferakis, Lamprini Troumpata, Aristodemos-Theodoros Periferakis, Andreea-Elena Scheau, Ioana Anca Badarau, Konstantinos Periferakis, Ana Caruntu, Ilinca Savulescu-Fiedler, Romina-Marina Sima, Daniela Calina, Carolina Constantin, Monica Neagu, Constantin Caruntu, and Cristian Scheau.

🔗 Read the article here https://brnw.ch/21wV51U

This highly cited review explores the diverse therapeutic and pharmacological potential of capsaicin, the bioactive compound of chili peppers. Acting mainly through the TRPV1 receptor, capsaicin shows promise in:

🌶️ Anti-inflammatory effects

🌶️ Anti-cancer activity (in vivo & in vitro)

🌶️ Antimicrobial action

🌶️ Potential synergy with acupuncture

🌶️ Clinical and industrial applications

⚠️ While its therapeutic potential is vast, capsaicin’s toxicity in sensitive tissues highlights the need for further research into safe and effective applications.
📖 Published in the Special Issue: Latest Review Papers in Molecular Biology 2024.

Capsaicin, the most prominent pungent compound of chilli peppers, has been used in traditional medicine systems for centuries; it already has a number of established clinical and industrial applications. Capsaicin is known to act through the TRPV1 receptor, which exists in various tissues; capsaicin...

20/08/2025

🧠 Exploring New Frontiers in Spinal Cord Injury Treatment

A recent review, The Therapeutic Potential of MicroRNA-21 in the Treatment of Spinal Cord Injury, examines how miR-21 could transform recovery outcomes for patients with SCI.
👉 Read the article https://brnw.ch/21wV4bP

miR-21 has been shown to influence key processes such as:
✨ Inflammation control
✨ Apoptosis regulation
✨ Tissue repair and regeneration

By modulating critical targets like PTEN and PDCD4, miR-21 plays a central role in shaping lesion repair and functional recovery. While challenges remain in clinical translation, its promise as a therapeutic target is clear.

📌 This paper sheds light on how molecular regulation may open new therapeutic pathways for SCI management.

Spinal cord injury (SCI) involves complex pathological processes that often result in significant and long-term neurological deficits. Increasingly, research has identified microRNA-21 (miR-21) as a pivotal regulator in SCI, with studies focusing on its roles in inflammation, apoptosis, and tissue r...

20/08/2025

🔬 Hot Topic in Molecular Biology

📖 Metabolite-Sensing Receptors: Emerging Targets for Modulating Chronic Pain Pathways
by Ciprian Pușcașu, Corina Andrei, Octavian Tudorel Olaru, and Anca Zanfirescu
👉 Read here https://brnw.ch/21wV3Ob

Chronic pain remains a major global health challenge. This article highlights how metabolite-sensing GPCRs—including GPR40, GPR43, GPR120, and TGR5—serve as critical modulators linking metabolic changes to inflammatory and degenerative processes.

These receptors influence nociceptive signaling and offer promising therapeutic targets for developing safer, more effective strategies to manage chronic pain.

⚡ Explore the molecular mechanisms, therapeutic potential, and clinical challenges in targeting these receptors.

Chronic pain is a debilitating condition affecting millions worldwide, often resulting from complex interactions between the nervous and immune systems. Recent advances highlight the critical role of metabolite-sensing G protein-coupled receptors (GPCRs) in various chronic pain types. These receptor...

19/08/2025

🦠 Highly Cited & Viewed: Antimicrobial Activity of Gallium(III) Compounds

⚡Gallium offers a promising strategy against bacterial infections by targeting multiple iron/heme-dependent processes, without contributing to antibiotic resistance. This review by Seoung-ryoung Choi et al. explores the mechanisms of gallium’s action and its potential in developing next-generation antimicrobial therapies.

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Metals play vital roles in biological systems, with iron/heme being essential for cellular and metabolic functions necessary for survival and/or virulence in many bacterial pathogens. Given the rise of bacterial resistance to current antibiotics, there is an urgent need for the development of non-to...

19/08/2025

🔬 Is Copper Still Safe for Us?

Explore the latest insights on copper’s essential roles and potential toxicity in humans. From cellular mechanisms to systemic effects, this review by Angelika Edyta Charkiewicz examines both the health benefits and risks of copper exposure, including its presence in everyday materials and diet.

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Copper (Cu) is a precious metal and one of the three most abundant trace elements in the body (50–120 mg). It is involved in a large number of cellular mechanisms and pathways and is an essential cofactor in the function of cellular enzymes. Both its excess and deficiency may be harmful for many d...

19/08/2025

Call for Papers: Plant Hormones, Development, and Stress Tolerance 🌱🔬'

Current Issues in Molecular Biology is pleased to announce a new Special Issue focused on the crucial role of plant hormones in development and environmental adaptation.

Guest Editors: Prof. Dr. Zhaohui Chu and Dr. Wei Yang.

Dear Colleagues,
Development and stress tolerance are key traits of plants necessary to establish their species-specific and environmental adaptation characteristics. Plant hormones, also known as phytohormones, are chemicals that are involved in plants’ development and stress tolerance. They have been broadly involved in the regulation of plant cell processes, either independently or involving crosstalk.
This Special Issue, entitled “Plant Hormones, Development, and Stress Tolerance”, aims to collect comprehensive reviews and articles focused on the latest progress on the study of plant development, abiotic and biotic stresses, plant hormone signaling transduction pathways, and their crosstalk. Additionally, any relative topics presenting high-quality findings on plant hormones will be considered as well.

Submission Deadline: 31 January 2026 🗓️
We look forward to your valuable contributions! 🚀

Learn more and submit your manuscript here: https://brnw.ch/21wV1je

18/08/2025

🧬 Highly Viewed & Cited!

Beyond the Coagulation Cascade: Vitamin K and Its Multifaceted Impact on Human and Domesticated Animal Health
by Rebecka A. Sadler et al.

Vitamin K isn’t just for blood clotting! This comprehensive review explores its role in brain, cardiovascular, bone, and immune health in humans, as well as in domesticated animals. The paper also examines its synergy with Vitamin D, nutrikinetics, safety, and potential therapeutic applications.

🔗 Read the full paper:

Vitamin K (VK) is an essential micronutrient impacting many systems in the body. This lipid-soluble vitamin is found in various plant and animal products and is absorbed via the lymphatic system. This biomolecule’s importance to human health includes but is not limited to its promotion of brain, c...

18/08/2025

🔬 Highly Cited & Viewed in Current Issues in Molecular Biology

“Epigallocatechin-3-gallate Synergistically Enhanced Arecoline-Induced Cytotoxicity by Redirecting Cycle Arrest to Apoptosis”
by Li-Jane Shih et al., Curr. Issues Mol. Biol., 2024, 46(2), 1516–1529. https://brnw.ch/21wV06z

EGCG, a green tea antioxidant, was shown to reduce ROS induced by the carcinogen arecoline while also promoting apoptosis in prostate cancer cells, highlighting its potential in cancer prevention and therapy.

Carcinogens, such as arecoline, play a crucial role in cancer progression and continuous gene mutations by generating reactive oxygen species (ROS). Antioxidants can reduce ROS levels and potentially prevent cancer progression but may paradoxically enhance the survival of cancer cells. This study in...

15/08/2025

🦷 Highly Cited Paper: Salivary Diagnosis of Dental Caries: A Systematic Review by Rita Antonelli, Valentina Massei, Elena Ferrari, et al.

This systematic review evaluates the reliability of salivary biomarkers for diagnosing dental caries. Analyzing 16 studies, the authors highlight key molecules—such as alpha-amylase, mucins, glycoproteins, interleukins, urease, and carbonic anhydrase VI—that could play an important diagnostic role. The study follows PRISMA guidelines and provides evidence-based insights for advancing non-invasive caries detection.

A must-read for researchers and clinicians interested in cariology, salivary diagnostics, and biomarker research.

🔗 Read here:

The activity of dental caries, combined with its multifactorial etiology, alters salivary molecule composition. The present systematic review was developed to answer the following question: “Are salivary biomarkers reliable for diagnosis of dental caries?”. Following the “Preferred Reporting I...