19/07/2025
ATHEROSCLEROSIS ✅✅✅
Atherosclerosis is a condition in which the arteries become narrowed and hardened due to a buildup of plaque (a mixture of fat, cholesterol, calcium, and other substances) on the inner walls of the blood vessels. This condition can lead to serious problems, including heart attack, stroke, and peripheral artery disease.
OR
The build-up of fats, cholesterol and other substances in and on the artery walls.
A build up of cholesterol plaque in the walls of arteries, causing obstruction of blood flow. Plaques may rupture, causing acute occlusion of the artery by clot.
Cause✅
Damage to the inner lining of the artery (endothelium), often from:
👉High blood pressure (hypertension)
👉Smoking
👉High cholesterol
👉Diabetes
👉Inflammation
Progression✅
👉Endothelial damage
👉LDL cholesterol enters the vessel wall
👉White blood cells (macrophages) try to digest the LDL → become foam cells
👉Fatty streaks form → develop into plaque
👉Plaque hardens → artery narrows
👉Plaque may rupture → blood clot (thrombosis)
Symptoms✅ (often appear late):
👉Coronary arteries (heart): Chest pain (angina), heart attack
👉Carotid arteries (brain): Stroke, sudden numbness, speech problems
👉Peripheral arteries (limbs): Leg pain while walking (claudication)
👉Renal arteries (kidneys): High blood pressure, kidney failure
Diagnosis✅
Blood tests (cholesterol, sugar)
👉ECG, Stress Test
👉Ultrasound, CT Angiography
👉Coronary Angiogram
Treatment✅
Lifestyle changes
👉Quit smoking
👉Healthy diet (low in saturated fat and cholesterol)
👉Regular exercise
👉Weight control
Medications💊
👉Statins (lower cholesterol)
👉Antiplatelets (e.g., aspirin)
👉Blood pressure meds (ACE inhibitors, beta-blockers)
👉Procedures (if severe):
👉Angioplasty and stent placement
👉Coronary artery bypass grafting (CABG)
Prevention:✅
Manage risk factors (diabetes, cholesterol, BP)
👉Avoid to***co
👉Eat fiber-rich diet
👉Stay physically active