JAMA Neurology

05/30/2026

A plasma staging model using and %p-tau217 demonstrated strong concordance with PET-based staging and clinical severity, supporting scalable, minimally invasive stratification.

https://ja.ma/4347mIQ

05/30/2026

An unusual congenital fusion of the left and right oculomotor nerves was identified in a child with complex and ptosis, demonstrating a rare variant of cranial nerve dysgenesis on neuroimaging. https://ja.ma/4v3qtOY

05/29/2026

Neurological teleconsultations in rural German shifted referrals from ambulatory neurologists to other specialists and hospitals, but did not increase sole management within general practice.

This stepped-wedge cluster randomized clinical trial evaluates whether teleneurology services in rural primary care in northeast Germany increased the proportion of patients with neurological symptoms or signs managed solely in general practice.

05/28/2026

In patients with , 4 weeks of electroacupuncture led to a greater reduction in pain severity and higher responder rates compared with sham, with effects persisting at 1 month. https://ja.ma/3Rx1l4X

05/28/2026

Among patients with multiple sclerosis treated long-term with ocrelizumab, interstitial lung disease developed after a mean of 10.5 years, mainly as organizing pneumonia with variable outcomes; prompt recognition and corticosteroid treatment are important.

This case series describes 6 cases of interstitial lung disease among patients with multiple sclerosis receiving long-term treatment with ocrelizumab.

05/27/2026

Among patients with , ecopipam maintained tic suppression and was well tolerated for up to 24 weeks, without clinically significant metabolic or movement disorder adverse effects. https://ja.ma/4wWNDZm

05/27/2026

Among adult patients with , discontinuation of oral immunosuppressants or rituximab was associated with a low 1-year relapse risk, especially after ≥1 year of treatment and ≥2 years since last relapse.

This cohort study evaluates the risk of relapse following treatment discontinuation among adults with myelin oligodendrocyte glycoprotein

05/26/2026

A plasma staging model using and %p-tau217 demonstrated strong concordance with PET-based staging and clinical severity, supporting scalable, minimally invasive stratification.

This longitudinal study develops and validates a blood plasma–based biological staging model for Alzheimer disease that closely mirrors an amyloid and tau positron emission tomography–based staging system.

05/26/2026

prevalence in England more than doubled in 30 years as survival improved, but abnormal weight, to***co use, and deprivation gradients persisted and were associated with increased mortality risk.

This cohort study examines trends in prevalence, lifestyle, and mortality among individuals with multiple sclerosis in England over 30 years.

05/25/2026

Among patients undergoing endovascular for acute , early (