JAMA Neurology

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Official page for JAMA Neurology http://jamaneuro.com, an international, peer-reviewed journal published weekly online and monthly in print.

Case report: a 23-year-old pregnant woman presented with seizures and chronic hepatitis B, with hyperintense lesions dis...
01/08/2026

Case report: a 23-year-old pregnant woman presented with seizures and chronic hepatitis B, with hyperintense lesions discovered in the left caudate nucleus on magnetic resonance imaging.

https://ja.ma/3Ld2coC

Relapse was frequent and temporally concentrated in the first 3 years among patients with biopsy-confirmed , emphasizin...
01/07/2026

Relapse was frequent and temporally concentrated in the first 3 years among patients with biopsy-confirmed , emphasizing the need for vigilant follow-up during this period. A normal CSF profile was associated with earlier and more frequent relapses than abnormal CSF, indicating that reliance on CSF findings to guide prognosis may be insufficient and should be validated in larger, prospective cohorts.

https://ja.ma/49oDb1x

General anesthesia improved 90-day disability outcomes and increased the rate of successful reperfusion compared with mo...
01/07/2026

General anesthesia improved 90-day disability outcomes and increased the rate of successful reperfusion compared with moderate sedation in patients undergoing endovascular thrombectomy for acute ischemic stroke.

https://ja.ma/4pqYAx3

In a patient with , new-onset dystonic posturing, blepharospasm, and abnormal gait were associated with structural lesi...
01/06/2026

In a patient with , new-onset dystonic posturing, blepharospasm, and abnormal gait were associated with structural lesions in the globus pallidus and bilateral defects in dopamine transporter function on PET imaging. https://ja.ma/44ZTktb

In a randomized clinical trial of women with prior , physician-optimized postpartum blood pressure self-management was ...
01/05/2026

In a randomized clinical trial of women with prior , physician-optimized postpartum blood pressure self-management was associated with larger white matter brain volumes at 9 months compared with usual care.

Women with a history of preeclampsia receiving usual care had smaller volumes in subcortical regions (putamen, accumbens, pallidum) than those with gestational hypertension, differences that were not observed in the intervention group.

https://ja.ma/49lLbR7

Frontotemporal is comparable in frequency to dementia with Lewy bodies and occurs at higher rates than progressive sup...
01/05/2026

Frontotemporal is comparable in frequency to dementia with Lewy bodies and occurs at higher rates than progressive supranuclear palsy, corticobasal syndrome, and amyotrophic lateral sclerosis.

https://ja.ma/4so3sWz

In patients with ischemic stroke and concurrent nonvalvular atrial fibrillation and ASCVD, adding an antiplatelet agent ...
01/04/2026

In patients with ischemic stroke and concurrent nonvalvular atrial fibrillation and ASCVD, adding an antiplatelet agent to anticoagulant therapy offered no net clinical benefit over anticoagulant monotherapy.

https://ja.ma/3YjxwF8

Among patients
01/02/2026

Among patients

A secondary analysis of the TEMPO-2 RCT found no significant improvement in outcomes for minor ischemic stroke patients ...
01/01/2026

A secondary analysis of the TEMPO-2 RCT found no significant improvement in outcomes for minor ischemic stroke patients treated with intravenous tenecteplase, regardless of the presence of disabling deficits.

https://ja.ma/3LfmBJF

Among patients
12/31/2025

Among patients

In the ATTENTION randomized clinical trial, individuals with acute basilar artery occlusion receiving EVT plus medical m...
12/29/2025

In the ATTENTION randomized clinical trial, individuals with acute basilar artery occlusion receiving EVT plus medical management had double the rate of favorable functional outcomes and a substantially lower cumulative 3-year mortality compared with those treated by medical management alone.

https://ja.ma/4sglVUR

In patients with ischemic stroke and concurrent nonvalvular atrial fibrillation and ASCVD, adding an antiplatelet agent ...
12/27/2025

In patients with ischemic stroke and concurrent nonvalvular atrial fibrillation and ASCVD, adding an antiplatelet agent to anticoagulant therapy offered no net clinical benefit over anticoagulant monotherapy. https://ja.ma/4pPSVBT

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